PMID- 34278242
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220813
IS  - 2577-3240 (Electronic)
IS  - 2577-3240 (Linking)
VI  - 3
IP  - 1
DP  - 2020 Feb
TI  - Molecular Mechanisms of Intermittent Fasting-induced Ischemic Tolerance.
PG  - 9-17
AB  - Diet is a significant factor in determining human well-being. Excessive eating 
      and/or diets with higher than needed amounts of carbohydrates, salt, and fat are 
      known to cause metabolic disorders and functional changes in the body. To 
      compensate the ill effects, many designer diets including the Mediterranean diet, 
      the Okinawa diet, vegetarian/vegan diets, keto diet, anti-inflammatory diet, and 
      the anti-oxidant diet have been introduced in the past 2 decades. While these 
      diets are either enriched or devoid of one or more specific components, a better 
      way to control diet is to limit the amount of food consumed. Caloric restriction 
      (CR), which involves limiting the amount of food consumed rather than eliminating 
      any specific type of food, as well as intermittent fasting (IF), which entails 
      limiting the time during which food can be consumed on a given day, have gained 
      popularity because of their positive effects on human health. While the molecular 
      mechanisms of these 2 dietary regimens have not been fully deciphered, they are 
      known to prolong the life span, control blood pressure, and blood glucose levels. 
      Furthermore, CR and IF were both shown to decrease the incidence of heart attack 
      and stroke, as well as their ill effects. In particular, IF is thought to promote 
      metabolic switching by altering gene expression profiles leading to reduced 
      inflammation and oxidative stress, while increasing plasticity and regeneration.
FAU - Vemuganti, Raghu
AU  - Vemuganti R
AD  - Department of Neurological Surgery, University of Wisconsin, Madison, WI, USA.
AD  - William S. Middleton VA Hospital, Madison, WI, USA.
FAU - Arumugam, Thiruma V
AU  - Arumugam TV
AD  - Department of Physiology, National University of Singapore, Singapore.
LA  - eng
GR  - R01 NS109459/NS/NINDS NIH HHS/United States
PT  - Journal Article
PL  - United States
TA  - Cond Med
JT  - Conditioning medicine
JID - 101718750
PMC - PMC8281895
MID - NIHMS1594284
OTO - NOTNLM
OT  - Brain
OT  - Dietary restriction
OT  - Inflammation
OT  - Neuroprotection
OT  - Oxidative stress
OT  - Stroke
EDAT- 2020/02/01 00:00
MHDA- 2020/02/01 00:01
PMCR- 2021/07/15
CRDT- 2021/07/19 06:05
PHST- 2021/07/19 06:05 [entrez]
PHST- 2020/02/01 00:00 [pubmed]
PHST- 2020/02/01 00:01 [medline]
PHST- 2021/07/15 00:00 [pmc-release]
PST - ppublish
SO  - Cond Med. 2020 Feb;3(1):9-17.