PMID- 34278900
OWN - NLM
STAT- MEDLINE
DCOM- 20220426
LR  - 20220602
IS  - 1532-7914 (Electronic)
IS  - 0163-5581 (Linking)
VI  - 74
IP  - 4
DP  - 2022
TI  - Body Mass Index Alters the Predictive Value of the Neutrophil-to-Lymphocyte Ratio 
      and Systemic Inflammation Response Index in Laryngeal Squamous Cell Carcinoma 
      Patients.
PG  - 1261-1269
LID - 10.1080/01635581.2021.1952447 [doi]
AB  - Laryngeal squamous cell carcinoma (LSCC) is a frequent cancer subtype among head 
      and neck cancers. Exacerbated inflammation and nutritional deficit are common 
      features in this type of cancer and can be used as a prognostic marker. This 
      study aimed to investigate the relationship between body mass index (BMI), 
      neutrophil-to-lymphocyte ratio (NLR), and systemic inflammation response index 
      (SIRI) on overall survival (OS) of LSCC patients. In this retrospective cohort 
      study, 168 patients were followed for 5 years. Data on clinical factors, 
      patients' life habits, height, weight, and hematological parameters were 
      collected. BMI, NLR, and SIRI were calculated. Pretreatment NLR>/= 2.02 and SIRI>/= 
      1160.85 were independent prognostic factors for poor OS. Low BMI did not 
      significantly affect the OS. However, the inflammatory parameters had their 
      predictive capacity altered when stratified by the BMI classification. NLR>/= 
      2.02 + Low BMI or SIRI>/= 1160.85 + Low BMI increased in 8.6 and 3.8 times the risk 
      of death, respectively. In contrast, stratification by normal/high BMI 
      classification eliminated the predictive capacity of NLR and SIRI. Here, we 
      demonstrated the possible ability of BMI to change the prognostic capacity of 
      inflammatory markers NLR and SIRI in patients with LSCC.Supplemental data for 
      this article is available online at 
      https://doi.org/10.1080/01635581.2021.1952447.
FAU - Murad, Luana Dalbem
AU  - Murad LD
AUID- ORCID: 0000-0001-8210-3000
AD  - Nutrition and Dietetics Section, Brazilian National Cancer Institute Jose Alencar 
      Gomes da Silva (INCA), Rio de Janeiro, RJ, Brazil.
AD  - Basic and Experimental Nutrition Department, Josue de Castro Nutrition Institute, 
      Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
FAU - Silva, Thays de Queiroz
AU  - Silva TQ
AD  - Basic and Experimental Nutrition Department, Josue de Castro Nutrition Institute, 
      Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
FAU - Schilithz, Arthur Orlando Correa
AU  - Schilithz AOC
AD  - Nutrition and Dietetics Section, Brazilian National Cancer Institute Jose Alencar 
      Gomes da Silva (INCA), Rio de Janeiro, RJ, Brazil.
FAU - Monteiro, Mariana Costa
AU  - Monteiro MC
AD  - Basic and Experimental Nutrition Department, Josue de Castro Nutrition Institute, 
      Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
FAU - Murad, Leonardo Borges
AU  - Murad LB
AD  - Nutrition and Dietetics Section, Brazilian National Cancer Institute Jose Alencar 
      Gomes da Silva (INCA), Rio de Janeiro, RJ, Brazil.
FAU - Fialho, Eliane
AU  - Fialho E
AD  - Basic and Experimental Nutrition Department, Josue de Castro Nutrition Institute, 
      Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210719
PL  - United States
TA  - Nutr Cancer
JT  - Nutrition and cancer
JID - 7905040
SB  - IM
MH  - Body Mass Index
MH  - *Head and Neck Neoplasms/pathology
MH  - Humans
MH  - Inflammation/pathology
MH  - Lymphocytes/pathology
MH  - *Neutrophils/pathology
MH  - Prognosis
MH  - Retrospective Studies
MH  - Squamous Cell Carcinoma of Head and Neck/pathology
EDAT- 2021/07/20 06:00
MHDA- 2022/04/27 06:00
CRDT- 2021/07/19 08:42
PHST- 2021/07/20 06:00 [pubmed]
PHST- 2022/04/27 06:00 [medline]
PHST- 2021/07/19 08:42 [entrez]
AID - 10.1080/01635581.2021.1952447 [doi]
PST - ppublish
SO  - Nutr Cancer. 2022;74(4):1261-1269. doi: 10.1080/01635581.2021.1952447. Epub 2021 
      Jul 19.