PMID- 34279713
OWN - NLM
STAT- MEDLINE
DCOM- 20220602
LR  - 20220814
IS  - 1435-2451 (Electronic)
IS  - 1435-2443 (Print)
IS  - 1435-2443 (Linking)
VI  - 407
IP  - 3
DP  - 2022 May
TI  - Simultaneous pancreas and kidney transplantation for end-stage kidney disease 
      patients with type 2 diabetes mellitus: a systematic review and meta-analysis.
PG  - 909-925
LID - 10.1007/s00423-021-02249-y [doi]
AB  - PURPOSE: The indications for patients with type 2 diabetes mellitus (T2DM) 
      combined with end-stage kidney disease (ESKD) undertaking simultaneous pancreas 
      and kidney transplantation (SPK) remain an unresolved issue. This study aimed to 
      systematically review the survival outcomes of SPK among T2DM-ESKD patients. 
      METHODS: Online databases including PubMed, MEDLINE, EMBASE, and the CENTRAL 
      Library, CNKI, Chinese Biomedical Literature Database, and Wan-Fang database were 
      used to locate the studies of ESKD patients with T2DM undertaking SPK up to May 
      2021. A third reviewer was consulted if there were disagreements. Data were 
      analyzed with STATA (15.0). RESULTS: Nine cohort studies were identified. The 
      pooled 1-year, 3-year, and 5-year patient survival rates of patients with T2DM 
      and ESKD after SPK were 98%, 95%, and 91% respectively. Comparing the treatment 
      effect of SPK between type 1 diabetes mellitus (T1DM) and T2DM, the survival 
      estimates were comparable. For T2DM patients, SPK had a survival advantage 
      compared with KTA. CONCLUSIONS: The synthesized clinical outcomes of T2DM 
      patients with ESKD after SPK were relatively better than KTA, but a subset of 
      T2DM-ESKD patients who would benefit the most from SPK was to be defined. 
      PROSPERO registration number CRD42019118321. Date of registration: 14 Jan 2019 
      (retrospectively registered).
CI  - (c) 2021. The Author(s).
FAU - Cao, Yu
AU  - Cao Y
AD  - Department of Kidney and Pancreas Transplantation, Tianjin First Central 
      Hospital, Tianjin, China.
FAU - Liu, Xiaoli
AU  - Liu X
AD  - Research Center of Clinical Epidemiology, Peking University Third Hospital, 
      Beijing, China.
FAU - Lan, Xiangyu
AU  - Lan X
AD  - Department of Kidney and Pancreas Transplantation, Tianjin First Central 
      Hospital, Tianjin, China.
FAU - Ni, Kaiwen
AU  - Ni K
AD  - Research Center of Clinical Epidemiology, Peking University Third Hospital, 
      Beijing, China.
FAU - Li, Lin
AU  - Li L
AD  - Department of Kidney and Pancreas Transplantation, Tianjin First Central 
      Hospital, Tianjin, China.
FAU - Fu, Yingxin
AU  - Fu Y
AUID- ORCID: 0000-0001-8010-224X
AD  - Department of Kidney and Pancreas Transplantation, Tianjin First Central 
      Hospital, Tianjin, China. yingxinfu@nankai.edu.cn.
LA  - eng
GR  - NO.8197033298/Major Research Plan/
GR  - NO.ZC20167/Tianjin Municipal Health Bureau/
GR  - NO.RC20090/Tianjin Municipal Health Bureau/
PT  - Journal Article
PT  - Meta-Analysis
PT  - Systematic Review
DEP - 20210719
PL  - Germany
TA  - Langenbecks Arch Surg
JT  - Langenbeck's archives of surgery
JID - 9808285
SB  - IM
MH  - *Diabetes Mellitus, Type 2/complications/surgery
MH  - Graft Survival
MH  - Humans
MH  - *Kidney Failure, Chronic/complications/surgery
MH  - *Kidney Transplantation/adverse effects
MH  - Pancreas
MH  - *Pancreas Transplantation
PMC - PMC9151548
OTO - NOTNLM
OT  - Kidney transplantation alone
OT  - Meta-analysis
OT  - Simultaneous pancreas and kidney transplantation
OT  - Survival outcomes
OT  - Type II diabetes
COIS- The authors declare no competing interests.
EDAT- 2021/07/20 06:00
MHDA- 2022/06/03 06:00
PMCR- 2021/07/19
CRDT- 2021/07/19 13:01
PHST- 2021/04/15 00:00 [received]
PHST- 2021/06/13 00:00 [accepted]
PHST- 2021/07/20 06:00 [pubmed]
PHST- 2022/06/03 06:00 [medline]
PHST- 2021/07/19 13:01 [entrez]
PHST- 2021/07/19 00:00 [pmc-release]
AID - 10.1007/s00423-021-02249-y [pii]
AID - 2249 [pii]
AID - 10.1007/s00423-021-02249-y [doi]
PST - ppublish
SO  - Langenbecks Arch Surg. 2022 May;407(3):909-925. doi: 10.1007/s00423-021-02249-y. 
      Epub 2021 Jul 19.