PMID- 3428013
OWN - NLM
STAT- MEDLINE
DCOM- 19880310
LR  - 20191210
IS  - 0253-2662 (Print)
IS  - 0253-2662 (Linking)
VI  - 20
IP  - 3
DP  - 1987 Aug
TI  - Effects of exogenous fat emulsion on lymphocyte function in septic rats.
PG  - 198-203
AB  - Effects of exogenous fat emulsion (Intralipid) on lymphocyte function were 
      studied, in vivo, with rats. Abdominal sepsis was induced in Sprague Dawley rats 
      by cecal ligation and puncture. Following a bolus infusion of the fat emulsion or 
      normal saline, lymphocyte proliferations after stimulation with 
      bacto-concanavalin A (Con A), phytohemagglutinin (PHA), and pokeweed mitogen 
      (PWM) were evaluated in animals divided into the following groups: group I, 
      non-septic rats receiving saline infusion (NS-S); group II, non-septic rats 
      receiving the fat emulsion (NS-F); group III, septic rats receiving saline (S-S); 
      group IV, septic rats receiving the fat emulsion (S-F). Results of the study 
      demonstrated that lymphocyte function was not suppressed by the presence of 
      sepsis, and infusion of the exogenous fat emulsion also did not lead to a 
      suppression of the lymphocyte function in either the septic or the non-septic 
      rats. The results obtained from a previous, as well as this present, study 
      suggest that although infusion of exogenous fat emulsion may suppress the 
      function of monocyte and polymorphonuclear cells, lymphocyte function is not 
      affected.
FAU - Chen, W J
AU  - Chen WJ
AD  - Department of Surgery, College of Medicine, National Taiwan University, Taipei, 
      ROC.
FAU - Mo, S T
AU  - Mo ST
FAU - Yu, L J
AU  - Yu LJ
FAU - Chen, K M
AU  - Chen KM
LA  - eng
PT  - Journal Article
PL  - China (Republic : 1949- )
TA  - Zhonghua Min Guo Wei Sheng Wu Ji Mian Yi Xue Za Zhi
JT  - Zhonghua Minguo wei sheng wu ji mian yi xue za zhi = Chinese journal of 
      microbiology and immunology
JID - 8008067
RN  - 0 (Fat Emulsions, Intravenous)
RN  - 0 (Mitogens)
SB  - IM
MH  - Animals
MH  - Fat Emulsions, Intravenous/*pharmacology
MH  - In Vitro Techniques
MH  - Infections/*immunology
MH  - Lymphocyte Activation/*drug effects
MH  - Mitogens/pharmacology
MH  - Rats
MH  - Rats, Inbred Strains
EDAT- 1987/08/01 00:00
MHDA- 1987/08/01 00:01
CRDT- 1987/08/01 00:00
PHST- 1987/08/01 00:00 [pubmed]
PHST- 1987/08/01 00:01 [medline]
PHST- 1987/08/01 00:00 [entrez]
PST - ppublish
SO  - Zhonghua Min Guo Wei Sheng Wu Ji Mian Yi Xue Za Zhi. 1987 Aug;20(3):198-203.