PMID- 34280808
OWN - NLM
STAT- MEDLINE
DCOM- 20211022
LR  - 20211022
IS  - 1532-8430 (Electronic)
IS  - 0022-0736 (Linking)
VI  - 68
DP  - 2021 Sep-Oct
TI  - Predictive value of frontal QRS-T angle after cardiac resynchronization therapy.
PG  - 24-29
LID - S0022-0736(21)00133-3 [pii]
LID - 10.1016/j.jelectrocard.2021.06.015 [doi]
AB  - OBJECTIVE: It is practical and useful to detect patients who benefit from cardiac 
      resynchronization therapy (CRT) by electrocardiographic (ECG) methods. In this 
      study, the predictive role of the frontal QRS-T angle and other ECG parameters 
      was evaluated in CRT responder patients. METHOD: Seventy-seven consecutive 
      patients with left ventricular ejection fraction (LVEF) </= 35%, New York Heart 
      Association (NYHA) classes II-III, ambulatory class IV and normal sinus rhythm, 
      who had complete left bundle branch block and were treated with CRT were included 
      in this study. Patients were classified as "CRT responders" and "CRT non 
      responders" according to their LVEF improvement. The frontal QRS-T angle was 
      calculated as the absolute value of the difference between the QRS and T wave 
      axes [frontal QRS-T angle = (QRS axis-T axis)]. RESULTS: The mean age of the 
      patients was 64.5 +/- 9.1 years, and the average follow-up was 28 (12-47) months. 
      The post-implantation LVEF was higher in the patients CRT responders group (p < 
      0.001). Post-implantation frontal QRS-T angle (p = 0.003), QRS duration (p = 
      0.008) and cQT interval (p = 0.012) values were much shorter in the CRT responder 
      group. Multivariable regression analyses showed that the frontal QRS-T angle and 
      age were independent risk factors for CRT response (p = 0.009). The results of 
      the receiver operating characteristic curve analyses (ROC) showed that the 
      predictive optimal cut-off value of CRT response for the frontal QRS-T angle was 
      <135 degrees (AUC: 0.69, 95% CI 0.575-0.814, p = 0.004). CONCLUSION: The narrowed 
      frontal QRS-T angle (<135 degrees), QRS duration and cQT interval were associated 
      with CRT response in heart failure patients. The frontal QRS-T angle can be an 
      independent predictor of CRT response.
CI  - Copyright (c) 2021 Elsevier Inc. All rights reserved.
FAU - Gunduz, Ramazan
AU  - Gunduz R
AD  - Department of Cardiology, Manisa City Hospital, Manisa 45040, Turkey.
FAU - Usalp, Songul
AU  - Usalp S
AD  - Department of Cardiology, Sancaktepe Sehit Profesor Ilhan Varank Education and 
      Research Hospital, Istanbul, Turkey. Electronic address: 
      dr.songulusalp@hotmail.com.
LA  - eng
PT  - Journal Article
DEP - 20210703
PL  - United States
TA  - J Electrocardiol
JT  - Journal of electrocardiology
JID - 0153605
SB  - IM
MH  - Aged
MH  - *Cardiac Resynchronization Therapy
MH  - Electrocardiography
MH  - *Heart Failure/therapy
MH  - Humans
MH  - Middle Aged
MH  - Stroke Volume
MH  - Treatment Outcome
MH  - Ventricular Function, Left
OTO - NOTNLM
OT  - Cardiac resynchronization therapy
OT  - Electrocardiography
OT  - Frontal QRS-T angle
OT  - Heart failure
COIS- Declaration of Competing Interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2021/07/20 06:00
MHDA- 2023/02/25 06:00
CRDT- 2021/07/19 20:25
PHST- 2021/05/03 00:00 [received]
PHST- 2021/06/10 00:00 [revised]
PHST- 2021/06/11 00:00 [accepted]
PHST- 2021/07/20 06:00 [pubmed]
PHST- 2023/02/25 06:00 [medline]
PHST- 2021/07/19 20:25 [entrez]
AID - S0022-0736(21)00133-3 [pii]
AID - 10.1016/j.jelectrocard.2021.06.015 [doi]
PST - ppublish
SO  - J Electrocardiol. 2021 Sep-Oct;68:24-29. doi: 10.1016/j.jelectrocard.2021.06.015. 
      Epub 2021 Jul 3.