PMID- 34281181
OWN - NLM
STAT- MEDLINE
DCOM- 20210729
LR  - 20230920
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 22
IP  - 13
DP  - 2021 Jul 1
TI  - Antimicrobial Activity of Curcumin in Nanoformulations: A Comprehensive Review.
LID - 10.3390/ijms22137130 [doi]
LID - 7130
AB  - Curcumin (CUR) is a natural substance extracted from turmeric that has 
      antimicrobial properties. Due to its ability to absorb light in the blue 
      spectrum, CUR is also used as a photosensitizer (PS) in antimicrobial 
      Photodynamic Therapy (aPDT). However, CUR is hydrophobic, unstable in solutions, 
      and has low bioavailability, which hinders its clinical use. To circumvent these 
      drawbacks, drug delivery systems (DDSs) have been used. In this review, we 
      summarize the DDSs used to carry CUR and their antimicrobial effect against 
      viruses, bacteria, and fungi, including drug-resistant strains and emergent 
      pathogens such as SARS-CoV-2. The reviewed DDSs include colloidal (micelles, 
      liposomes, nanoemulsions, cyclodextrins, chitosan, and other polymeric 
      nanoparticles), metallic, and mesoporous particles, as well as graphene, quantum 
      dots, and hybrid nanosystems such as films and hydrogels. Free (non-encapsulated) 
      CUR and CUR loaded in DDSs have a broad-spectrum antimicrobial action when used 
      alone or as a PS in aPDT. They also show low cytotoxicity, in vivo 
      biocompatibility, and improved wound healing. Although there are several in vitro 
      and some in vivo investigations describing the nanotechnological aspects and the 
      potential antimicrobial application of CUR-loaded DDSs, clinical trials are not 
      reported and further studies should translate this evidence to the clinical 
      scenarios of infections.
FAU - Trigo-Gutierrez, Jeffersson Krishan
AU  - Trigo-Gutierrez JK
AUID- ORCID: 0000-0002-1004-2429
AD  - Laboratory of Applied Microbiology, Department of Dental Materials and 
      Prosthodontics, School of Dentistry, Sao Paulo State University (Unesp), 
      Araraquara 14800-000, Brazil.
FAU - Vega-Chacon, Yuliana
AU  - Vega-Chacon Y
AD  - Laboratory of Applied Microbiology, Department of Dental Materials and 
      Prosthodontics, School of Dentistry, Sao Paulo State University (Unesp), 
      Araraquara 14800-000, Brazil.
FAU - Soares, Amanda Brandao
AU  - Soares AB
AD  - Laboratory of Applied Microbiology, Department of Dental Materials and 
      Prosthodontics, School of Dentistry, Sao Paulo State University (Unesp), 
      Araraquara 14800-000, Brazil.
FAU - Mima, Ewerton Garcia de Oliveira
AU  - Mima EGO
AUID- ORCID: 0000-0002-9575-7625
AD  - Laboratory of Applied Microbiology, Department of Dental Materials and 
      Prosthodontics, School of Dentistry, Sao Paulo State University (Unesp), 
      Araraquara 14800-000, Brazil.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20210701
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (Anti-Infective Agents)
RN  - 0 (Micelles)
RN  - IT942ZTH98 (Curcumin)
SB  - IM
MH  - Anti-Infective Agents/*administration & dosage
MH  - Curcumin/*administration & dosage/chemistry
MH  - Drug Delivery Systems/*methods
MH  - Humans
MH  - Micelles
MH  - Nanomedicine/methods
MH  - Nanoparticles/*administration & dosage/chemistry
PMC - PMC8267827
OTO - NOTNLM
OT  - antimicrobial agents
OT  - bacteria
OT  - curcumin
OT  - drug delivery systems
OT  - fungi
OT  - microbial drug resistance
OT  - photochemotherapy
OT  - viruses
COIS- The authors declare no conflict of interest.
EDAT- 2021/07/21 06:00
MHDA- 2021/07/30 06:00
PMCR- 2021/07/01
CRDT- 2021/07/20 01:03
PHST- 2021/05/20 00:00 [received]
PHST- 2021/06/21 00:00 [revised]
PHST- 2021/06/28 00:00 [accepted]
PHST- 2021/07/20 01:03 [entrez]
PHST- 2021/07/21 06:00 [pubmed]
PHST- 2021/07/30 06:00 [medline]
PHST- 2021/07/01 00:00 [pmc-release]
AID - ijms22137130 [pii]
AID - ijms-22-07130 [pii]
AID - 10.3390/ijms22137130 [doi]
PST - epublish
SO  - Int J Mol Sci. 2021 Jul 1;22(13):7130. doi: 10.3390/ijms22137130.