PMID- 34281266
OWN - NLM
STAT- MEDLINE
DCOM- 20210726
LR  - 20210726
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 22
IP  - 13
DP  - 2021 Jul 5
TI  - Roles of MicroRNAs in Osteogenesis or Adipogenesis Differentiation of Bone Marrow 
      Stromal Progenitor Cells.
LID - 10.3390/ijms22137210 [doi]
LID - 7210
AB  - Bone marrow stromal cells (BMSCs) are multipotent cells which can differentiate 
      into chondrocytes, osteoblasts, and fat cells. Under pathological stress, reduced 
      bone formation in favour of fat formation in the bone marrow has been observed 
      through a switch in the differentiation of BMSCs. The bone/fat switch causes bone 
      growth defects and disordered bone metabolism in bone marrow, for which the 
      mechanisms remain unclear, and treatments are lacking. Studies suggest that small 
      non-coding RNAs (microRNAs) could participate in regulating BMSC differentiation 
      by disrupting the post-transcription of target genes, leading to bone/fat 
      formation changes. This review presents an emerging concept of microRNA 
      regulation in the bone/fat formation switch in bone marrow, the evidence for 
      which is assembled mainly from in vivo and in vitro human or animal models. 
      Characterization of changes to microRNAs reveals novel networks that mediate 
      signalling and factors in regulating bone/fat switch and homeostasis. Recent 
      advances in our understanding of microRNAs in their control in BMSC 
      differentiation have provided valuable insights into underlying mechanisms and 
      may have significant potential in development of new therapeutics.
FAU - Zhang, Ya-Li
AU  - Zhang YL
AUID- ORCID: 0000-0003-0107-4274
AD  - UniSA Clinical and Health Sciences, University of South Australia, Adelaide, SA 
      5000, Australia.
FAU - Liu, Liang
AU  - Liu L
AUID- ORCID: 0000-0002-6272-2565
AD  - UniSA Clinical and Health Sciences, University of South Australia, Adelaide, SA 
      5000, Australia.
FAU - Peymanfar, Yaser
AU  - Peymanfar Y
AUID- ORCID: 0000-0002-5793-0474
AD  - UniSA Clinical and Health Sciences, University of South Australia, Adelaide, SA 
      5000, Australia.
FAU - Anderson, Paul
AU  - Anderson P
AD  - UniSA Clinical and Health Sciences, University of South Australia, Adelaide, SA 
      5000, Australia.
FAU - Xian, Cory J
AU  - Xian CJ
AUID- ORCID: 0000-0002-8467-2845
AD  - UniSA Clinical and Health Sciences, University of South Australia, Adelaide, SA 
      5000, Australia.
LA  - eng
GR  - 1127396/National Health and Medical Research Council/
PT  - Journal Article
PT  - Review
DEP - 20210705
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (Bone Morphogenetic Proteins)
RN  - 0 (Genetic Markers)
RN  - 0 (MicroRNAs)
RN  - 0 (Smad Proteins)
RN  - 0 (Transforming Growth Factor beta)
SB  - IM
MH  - Adipogenesis/*genetics/*physiology
MH  - Animals
MH  - Bone Morphogenetic Proteins/genetics/metabolism
MH  - Calcium Signaling/genetics
MH  - Cell Differentiation/genetics/physiology
MH  - Genetic Markers
MH  - Humans
MH  - Mesenchymal Stem Cells/*cytology/*metabolism
MH  - MicroRNAs/genetics/metabolism
MH  - Models, Biological
MH  - Osteogenesis/*genetics/*physiology
MH  - Signal Transduction/genetics
MH  - Smad Proteins/genetics/metabolism
MH  - Transforming Growth Factor beta/genetics/metabolism
MH  - Wnt Signaling Pathway/genetics
PMC - PMC8269269
OTO - NOTNLM
OT  - BMSC differentiation
OT  - bone/fat formation
OT  - microRNAs
COIS- The Authors declare that they have no conflict of interest.
EDAT- 2021/07/21 06:00
MHDA- 2021/07/27 06:00
PMCR- 2021/07/05
CRDT- 2021/07/20 01:03
PHST- 2021/06/21 00:00 [received]
PHST- 2021/07/02 00:00 [revised]
PHST- 2021/07/03 00:00 [accepted]
PHST- 2021/07/20 01:03 [entrez]
PHST- 2021/07/21 06:00 [pubmed]
PHST- 2021/07/27 06:00 [medline]
PHST- 2021/07/05 00:00 [pmc-release]
AID - ijms22137210 [pii]
AID - ijms-22-07210 [pii]
AID - 10.3390/ijms22137210 [doi]
PST - epublish
SO  - Int J Mol Sci. 2021 Jul 5;22(13):7210. doi: 10.3390/ijms22137210.