PMID- 34282680
OWN - NLM
STAT- MEDLINE
DCOM- 20230316
LR  - 20230413
IS  - 1089-4098 (Electronic)
IS  - 1073-8584 (Linking)
VI  - 29
IP  - 2
DP  - 2023 Apr
TI  - Topography of the Anxious Self: Abnormal Rest-Task Modulation in Social Anxiety 
      Disorder.
PG  - 221-244
LID - 10.1177/10738584211030497 [doi]
AB  - Social anxiety disorder (SAD) is characterized by social anxiety/fear, 
      self-attention, and interoception. Functional magnetic resonance imaging studies 
      demonstrate increased activity during symptom-sensitive tasks in regions of the 
      default-mode network (DMN), amygdala (AMG), and salience network (SN). What is 
      the source of this task-unspecific symptom-sensitive hyperactivity in DMN? We 
      address this question by probing SAD resting state (rs) changes in DMN including 
      their relation to other regions as possible source of task-unspecific 
      hyperactivity in the same regions. Our findings show the following: (1) 
      rs-hypoconnectivity within-DMN regions; (2) rs-hyperconnectivity between DMN and 
      AMG/SN; (3) task-evoked hyperactivity in the abnormal rs-regions of DMN and 
      AMG/SN during different symptom-sensitive tasks; (4) negative relationship of 
      rest and task changes in especially anterior DMN regions as their 
      rs-hypoconnectivity is accompanied by task-unspecific hyperactivity; (5) abnormal 
      top-down/bottom-up modulation between anterior DMN regions and AMG during rest 
      and task. Findings demonstrate that rs-hypoconnectivity among DMN regions is 
      negatively related to task-unspecific hyperactivity in DMN and AMG/SN. We propose 
      a model of "Topography of the Anxious Self" in SAD (TAS-SAD). Abnormal DMN-AMG/SN 
      topography during rest, as trait feature of an "unstable social self", is 
      abnormally aggravated during SAD-sensitive situations resulting in task-related 
      hyperactivity in the same regions with an "anxious self" as state feature.
FAU - Lucherini Angeletti, Lorenzo
AU  - Lucherini Angeletti L
AUID- ORCID: 0000-0001-6473-7034
AD  - Psychiatry Unit, Department of Health Sciences, University of Florence, Florence, 
      Italy.
FAU - Scalabrini, Andrea
AU  - Scalabrini A
AD  - Department of Psychological Health and Territorial Sciences (DiSPuTer), G. 
      d'Annunzio University of Chieti-Pescara, Chieti, Italy.
FAU - Ricca, Valdo
AU  - Ricca V
AD  - Psychiatry Unit, Department of Health Sciences, University of Florence, Florence, 
      Italy.
FAU - Northoff, Georg
AU  - Northoff G
AD  - Mental Health Centre, Zhejiang University School of Medicine, Hangzhou, China.
AD  - Centre for Cognition and Brain Disorders, Hangzhou Normal University, Hangzhou, 
      China.
AD  - The Royal's Institute of Mental Health Research & University of Ottawa, Ottawa, 
      Ontario, Canada.
AD  - Centre for Neural Dynamics, Faculty of Medicine, Brain and Mind Research 
      Institute, University of Ottawa, Ottawa, Ontario, Canada.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20210720
PL  - United States
TA  - Neuroscientist
JT  - The Neuroscientist : a review journal bringing neurobiology, neurology and 
      psychiatry
JID - 9504819
SB  - IM
MH  - Humans
MH  - *Phobia, Social/diagnostic imaging
MH  - Brain/diagnostic imaging
MH  - Brain Mapping
MH  - Attention
MH  - Rest/physiology
MH  - Magnetic Resonance Imaging/methods
MH  - Anxiety/diagnostic imaging
MH  - Neural Pathways
OTO - NOTNLM
OT  - amygdala
OT  - anxious self
OT  - default-mode network
OT  - fMRI
OT  - rest-task interaction
OT  - resting state functional connectivity
OT  - salience network
OT  - social anxiety disorder
OT  - task-induced activity
OT  - unstable social self
EDAT- 2021/07/21 06:00
MHDA- 2023/03/17 06:00
CRDT- 2021/07/20 08:36
PHST- 2021/07/21 06:00 [pubmed]
PHST- 2023/03/17 06:00 [medline]
PHST- 2021/07/20 08:36 [entrez]
AID - 10.1177/10738584211030497 [doi]
PST - ppublish
SO  - Neuroscientist. 2023 Apr;29(2):221-244. doi: 10.1177/10738584211030497. Epub 2021 
      Jul 20.