PMID- 34283292
OWN - NLM
STAT- MEDLINE
DCOM- 20211020
LR  - 20220310
IS  - 1435-702X (Electronic)
IS  - 0721-832X (Print)
IS  - 0721-832X (Linking)
VI  - 259
IP  - 11
DP  - 2021 Nov
TI  - In vivo corneal confocal microscopy and optical coherence tomography on eyes of 
      participants with type 2 diabetes mellitus and obese participants without 
      diabetes.
PG  - 3339-3350
LID - 10.1007/s00417-021-05251-8 [doi]
AB  - PURPOSES: To examine corneal nerve and retinal nerve characteristics of 
      participants with type 2 diabetes mellitus (T2DM) compared with obese 
      participants without diabetes to discover potential nerve vulnerabilities. 
      METHODS: All participants underwent a complete medical examination including a 
      physical examination and blood sample tests. The ophthalmologic examination 
      included best-corrected visual acuity, intraocular pressure, Schirmer test, tear 
      film breakup time, slit-lamp examination, dilated fundus photography, in vivo 
      corneal confocal microscopy (IVCCM), and optical coherence tomography (OCT). 
      RESULTS: The study cohort consisted of 83 eyes of 83 individuals: a group of 44 
      participants with T2DM, and a control group of 39 obese participants with no 
      history of diabetes. Comparing measurements on the two groups, participants with 
      T2DM had lower values with statistical significance for retinal nerve fiber layer 
      (RNFL) nasal superior thickness (p = 0.010) and three corneal nerve (CN) 
      parameters: fiber length (p = 0.025), total branch density (p = 0.013), and fiber 
      area (p = 0.009). There was a borderline significant difference in CN fiber width 
      (p = 0.051) and RNFL nasal inferior thickness (p = 0.056). No other significant 
      differences were observed in the IVCCM and OCT parameters. No statistically 
      significant correlation was found between CN and RNFL parameters. CONCLUSIONS: 
      Progression from a pre-diabetic obese state to a T2DM condition might entail a 
      loss or diminishment of certain corneal nerve fibers or retinal nerve fibers, but 
      not necessarily a loss of both corneal and retinal nerve fibers simultaneously. 
      Using IVCCM and OCT together enables monitoring of both corneal and retinal 
      health of the eye.
CI  - (c) 2021. The Author(s).
FAU - Toth, Noemi
AU  - Toth N
AD  - Department of Ophthalmology, University of Pecs, Medical School, Akac u. 1, Pecs, 
      7623, Hungary.
AD  - Department of Ophthalmology, Faculty of Medicine, University of Debrecen, 
      Debrecen, 4032, Hungary.
AD  - Doctoral School of Clinical Medicine, University of Debrecen, Debrecen, 4032, 
      Hungary.
FAU - Silver, David M
AU  - Silver DM
AD  - Johns Hopkins University, Bethesda, MA, 20816, USA.
FAU - Balla, Szabolcs
AU  - Balla S
AD  - Department of Ophthalmology, Faculty of Medicine, University of Debrecen, 
      Debrecen, 4032, Hungary.
FAU - Kaplar, Miklos
AU  - Kaplar M
AD  - Division of Metabolic Diseases, Department of Internal Medicine, Faculty of 
      Medicine, University of Debrecen, Debrecen, 4032, Hungary.
FAU - Csutak, Adrienne
AU  - Csutak A
AUID- ORCID: 0000-0002-7821-2412
AD  - Department of Ophthalmology, University of Pecs, Medical School, Akac u. 1, Pecs, 
      7623, Hungary. csutak.adrienne@pte.hu.
AD  - Department of Ophthalmology, Faculty of Medicine, University of Debrecen, 
      Debrecen, 4032, Hungary. csutak.adrienne@pte.hu.
AD  - Doctoral School of Clinical Medicine, University of Debrecen, Debrecen, 4032, 
      Hungary. csutak.adrienne@pte.hu.
LA  - eng
GR  - 2020/02/PTE-AOK KA/
GR  - 2.1.1-15-2015-00609./GINOP/
PT  - Journal Article
DEP - 20210720
PL  - Germany
TA  - Graefes Arch Clin Exp Ophthalmol
JT  - Graefe's archive for clinical and experimental ophthalmology = Albrecht von 
      Graefes Archiv fur klinische und experimentelle Ophthalmologie
JID - 8205248
SB  - IM
MH  - Cross-Sectional Studies
MH  - *Diabetes Mellitus, Type 2/complications/diagnosis
MH  - Humans
MH  - Microscopy, Confocal
MH  - Obesity/complications/diagnosis
MH  - Retinal Ganglion Cells
MH  - *Tomography, Optical Coherence
PMC - PMC8523500
OTO - NOTNLM
OT  - In vivo confocal corneal microscopy
OT  - OCT
OT  - Obesity
OT  - Type 2 diabetes mellitus
COIS- The authors declare no competing interests.
EDAT- 2021/07/21 06:00
MHDA- 2021/10/21 06:00
PMCR- 2021/07/20
CRDT- 2021/07/20 12:27
PHST- 2021/01/28 00:00 [received]
PHST- 2021/05/19 00:00 [accepted]
PHST- 2021/05/07 00:00 [revised]
PHST- 2021/07/21 06:00 [pubmed]
PHST- 2021/10/21 06:00 [medline]
PHST- 2021/07/20 12:27 [entrez]
PHST- 2021/07/20 00:00 [pmc-release]
AID - 10.1007/s00417-021-05251-8 [pii]
AID - 5251 [pii]
AID - 10.1007/s00417-021-05251-8 [doi]
PST - ppublish
SO  - Graefes Arch Clin Exp Ophthalmol. 2021 Nov;259(11):3339-3350. doi: 
      10.1007/s00417-021-05251-8. Epub 2021 Jul 20.