PMID- 34284376
OWN - NLM
STAT- MEDLINE
DCOM- 20210916
LR  - 20210916
IS  - 1938-2650 (Electronic)
IS  - 0001-5547 (Linking)
VI  - 65
IP  - 5
DP  - 2021
TI  - Cytological Appearances of Ovarian Seromucinous Borderline Tumor in Ascites: 
      Presentation of 2 Cases.
PG  - 440-447
LID - 10.1159/000517313 [doi]
AB  - BACKGROUND: Seromucinous borderline tumor (SMBT) is a rare neoplasm which was 
      newly defined in the 2014 WHO classification. Although the clinical and 
      histopathological characteristics of SMBT have been well described, its 
      cytological characteristics have not. We recently experienced 2 cases of SMBT 
      which were defined by cytological findings of ascites. CASE PRESENTATION: Case 1 
      was a 65-year-old Japanese woman. Preoperative imaging studies revealed abundant 
      ascites and a cystic tumor, with a solid component measuring 13 cm on the left 
      ovary. Radical surgery was performed during the intraoperative diagnosis of 
      ovarian borderline tumor, made by histological examinations of frozen tumor 
      sections. The cytological smears of preoperatively and intraoperatively collected 
      ascites showed many atypical cells resembling reactive mesothelial cells. 
      Alcian-blue staining of cell block sections revealed intracytoplasmic mucin, and 
      the results of immunohistochemistry were consistent with SMBT. The final 
      pathological diagnosis of tumor was SMBT. Case 2 was a 28-year-old Japanese 
      woman. Preoperative imaging studies revealed a small amount of ascites and cystic 
      tumors with solid components in the bilateral ovaries. She initially underwent 
      fertility preservation surgery. SMBT was suspected by cytological examination of 
      smears of intraoperatively collected ascites and the findings of cell block. She 
      underwent additional radical surgery based on a final pathological diagnosis of 
      SMBT. CONCLUSION: In our experience, the tumor cells of SMBT in ascites mimicked 
      reactive mesothelial cells. The nuclear atypia of SMBTs was intermediate between 
      that of reactive mesothelial cells and serous carcinoma. The immunohistochemistry 
      and mucin staining using cell block were very helpful for facilitating the 
      cytodiagnosis of SMBT.
CI  - (c) 2021 S. Karger AG, Basel.
FAU - Kai, Keita
AU  - Kai K
AD  - Department of Pathology, Saga University Hospital, Saga, Japan.
FAU - Hashiguchi, Mariko
AU  - Hashiguchi M
AD  - Department of Obstetrics & Gynecology, Faculty of Medicine, Saga University, 
      Saga, Japan.
FAU - Kurihara, Makiko
AU  - Kurihara M
AD  - Department of Obstetrics & Gynecology, Faculty of Medicine, Saga University, 
      Saga, Japan.
FAU - Tanaka, Yuya
AU  - Tanaka Y
AD  - Department of Pathology, Saga University Hospital, Saga, Japan.
FAU - Kitamura, Sho
AU  - Kitamura S
AD  - Department of Pathology, Saga University Hospital, Saga, Japan.
FAU - Nakamura, Mitsuo
AU  - Nakamura M
AD  - Department of Pathology, Saga University Hospital, Saga, Japan.
FAU - Shichijo, Chika
AU  - Shichijo C
AD  - Department of Pathology & Microbiology, Saga University Faculty of Medicine, 
      Saga, Japan.
FAU - Yamamoto-Rikitake, Mihoko
AU  - Yamamoto-Rikitake M
AD  - Department of Pathology & Microbiology, Saga University Faculty of Medicine, 
      Saga, Japan.
FAU - Okuma, Ryoichi
AU  - Okuma R
AD  - Department of Obstetrics & Gynecology, Faculty of Medicine, Saga University, 
      Saga, Japan.
FAU - Hikari, Takako
AU  - Hikari T
AD  - Department of Obstetrics & Gynecology, Faculty of Medicine, Saga University, 
      Saga, Japan.
FAU - Okuma, Emi
AU  - Okuma E
AD  - Department of Obstetrics & Gynecology, Faculty of Medicine, Saga University, 
      Saga, Japan.
FAU - Uchiyama, Michiko
AU  - Uchiyama M
AD  - Department of Obstetrics & Gynecology, Faculty of Medicine, Saga University, 
      Saga, Japan.
FAU - Aoki, Shigehisa
AU  - Aoki S
AD  - Department of Pathology & Microbiology, Saga University Faculty of Medicine, 
      Saga, Japan.
FAU - Nakao, Yoshifumi
AU  - Nakao Y
AD  - Department of Obstetrics & Gynecology, Faculty of Medicine, Saga University, 
      Saga, Japan.
FAU - Yokoyama, Masatoshi
AU  - Yokoyama M
AD  - Department of Obstetrics & Gynecology, Faculty of Medicine, Saga University, 
      Saga, Japan.
FAU - Aishima, Shinichi
AU  - Aishima S
AD  - Department of Pathology, Saga University Hospital, Saga, Japan.
AD  - Department of Pathology & Microbiology, Saga University Faculty of Medicine, 
      Saga, Japan.
LA  - eng
PT  - Case Reports
DEP - 20210720
PL  - Switzerland
TA  - Acta Cytol
JT  - Acta cytologica
JID - 0370307
SB  - IM
MH  - Adenocarcinoma, Mucinous/diagnosis/*surgery
MH  - Aged
MH  - Ascites/diagnosis/*surgery
MH  - Diagnosis, Differential
MH  - Female
MH  - Humans
MH  - Immunohistochemistry/methods
MH  - Ovarian Neoplasms/diagnosis/*pathology
MH  - Ovary/metabolism/*pathology
OTO - NOTNLM
OT  - Ascites
OT  - Gynecologic cytology
OT  - Ovary
OT  - Seromucinous borderline tumor
EDAT- 2021/07/21 06:00
MHDA- 2021/09/18 06:00
CRDT- 2021/07/20 20:26
PHST- 2021/03/03 00:00 [received]
PHST- 2021/05/17 00:00 [accepted]
PHST- 2021/07/21 06:00 [pubmed]
PHST- 2021/09/18 06:00 [medline]
PHST- 2021/07/20 20:26 [entrez]
AID - 000517313 [pii]
AID - 10.1159/000517313 [doi]
PST - ppublish
SO  - Acta Cytol. 2021;65(5):440-447. doi: 10.1159/000517313. Epub 2021 Jul 20.