PMID- 34285325
OWN - NLM
STAT- MEDLINE
DCOM- 20211110
LR  - 20211110
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 11
IP  - 1
DP  - 2021 Jul 20
TI  - Risk factors for onset or progression of epiretinal membrane after cataract 
      surgery.
PG  - 14808
LID - 10.1038/s41598-021-94352-9 [doi]
LID - 14808
AB  - While the precise diagnosis of early stage epiretinal membrane (ERM) at the time 
      of cataract surgery and evaluation of risk factors for development or progression 
      of ERM after cataract surgery is increasingly important, there is only limited 
      information. In the present study, we evaluated the risk factors for onset or 
      progression of ERM on spectral domain optical coherence tomography (SD-OCT) after 
      cataract surgery. The univariate analysis showed that eyes with partial posterior 
      vitreous detachment (PVD; p < 0.001), hyper-reflective foci (HF) on the inner 
      retinal surface (p < 0.001), vitreoschisis (p = 0.014), and discrete margin of 
      different retinal reflectivity (DMDRR; p = 0.007) on ultra-widefield fundus 
      photography (UWF-FP) had significant risk for the onset or progression of ERM 
      after cataract surgery. The multivariate analysis showed that partial PVD (HR, 
      3.743; 95% confidence interval [CI], 1.956-7.162; p < 0.001), HF (HR, 2.330; 95% 
      CI, 1.281-4.239; p = 0.006), and DMDRR on UWF-FP (HR, 3.392; 95% CI, 1.522-7.558; 
      p = 0.003) were the independent risk factors for the onset or progression of ERM 
      after cataract surgery after adjustment for other confounding factors. Our study 
      shows that the onset or progression of ERM after cataract surgery depends on an 
      abnormal vitreoretinal interface (VRI) represented by partial PVD, HF on SD-OCT, 
      and DMDRR on UWF-FP, not on age, axial length, or presence of ERM at the time of 
      surgery. A meticulous funduscopic evaluation of the VRI would help to predict the 
      ERM risk before cataract surgery.
CI  - (c) 2021. The Author(s).
FAU - Kwon, Soonil
AU  - Kwon S
AD  - Department of Ophthalmology, Hallym University Sacred Heart Hospital, Anyang, 
      Republic of Korea.
FAU - Kim, Boyun
AU  - Kim B
AD  - Keye Eye Center, 326 Teheran-ro, Gangnam-gu, Seoul, Republic of Korea.
FAU - Jeon, Sohee
AU  - Jeon S
AD  - Keye Eye Center, 326 Teheran-ro, Gangnam-gu, Seoul, Republic of Korea. 
      soheeeee@gmail.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210720
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
SB  - IM
MH  - Age of Onset
MH  - Aged
MH  - Cataract Extraction/*adverse effects
MH  - Disease Progression
MH  - Early Diagnosis
MH  - Epiretinal Membrane/*diagnostic imaging/etiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Tomography, Optical Coherence
PMC - PMC8292410
COIS- The authors declare no competing interests.
EDAT- 2021/07/22 06:00
MHDA- 2021/11/11 06:00
PMCR- 2021/07/20
CRDT- 2021/07/21 06:21
PHST- 2021/05/25 00:00 [received]
PHST- 2021/07/09 00:00 [accepted]
PHST- 2021/07/21 06:21 [entrez]
PHST- 2021/07/22 06:00 [pubmed]
PHST- 2021/11/11 06:00 [medline]
PHST- 2021/07/20 00:00 [pmc-release]
AID - 10.1038/s41598-021-94352-9 [pii]
AID - 94352 [pii]
AID - 10.1038/s41598-021-94352-9 [doi]
PST - epublish
SO  - Sci Rep. 2021 Jul 20;11(1):14808. doi: 10.1038/s41598-021-94352-9.