PMID- 34285560
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220425
IS  - 1178-7074 (Print)
IS  - 1178-7074 (Electronic)
IS  - 1178-7074 (Linking)
VI  - 14
DP  - 2021
TI  - Short-Term Impact of Iron Deficiency in Different Subsets of Patients with 
      Precapillary Pulmonary Hypertension from an Eastern European Pulmonary 
      Hypertension Referral Center.
PG  - 3355-3366
LID - 10.2147/IJGM.S318343 [doi]
AB  - BACKGROUND: Over the last few decades, interest in the role of iron status in 
      pulmonary hypertension (PH) has grown considerably due to its potential impact on 
      symptoms, exercise capacity (as assessed by the 6-minute walk distance [6MWD]), 
      prognosis, and mortality. The aim of the present study was to identify iron 
      deficiency (ID) prevalence in specific precapillary PH subgroups of Romanian 
      patients and its short-term impact on 6MWD. PATIENTS AND METHODS: Complete 
      datasets from 25 precapillary PH adults were examined and included in the 
      analysis. Data were collected at baseline and after continuous follow-up of an 
      average of 13.5 months. Enrolled patients were assigned to group 1 (pulmonary 
      arterial hypertension) or subgroup 4.1 (chronic thromboembolic pulmonary 
      hypertension), and individualized targeted therapy was prescribed. General 
      characteristics, World Health Organization functional class, 6MWD, pulse 
      oximetry, laboratory parameters, and echocardiographic and hemodynamic parameters 
      were recorded. Ferritin values and transferrin saturation were used to assess ID. 
      RESULTS: At baseline, 16 out of 25 patients were iron deficient. The univariate 
      linear regression analysis did not show a statistically significant impact of ID 
      on 6MWD (p=0.428). In multivariate regression analysis, possible predictors of 
      6MWD, including ID, were not statistically significant at baseline or after an 
      average of 13.5 months follow-up (p=0.438, 0.361, respectively) and ID indicates 
      a negative impact on 6MWD independent of applied corrections. CONCLUSION: The 
      results of this study demonstrate that 1.4.1 subgroup PAH patients have an 
      increased prevalence of ID compared with other etiologies. ID has a negative 
      impact on the functional status (assessed by 6MWD), in specific groups and 
      subgroups of patients with precapillary PH, albeit not independently nor 
      significant to other known predictors such as age, gender, oxygen saturation, and 
      hemoglobin value. These data can be integrated with global research and are 
      consistent with phenotypes of patients diagnosed with PH of different etiologies.
CI  - (c) 2021 Tilea et al.
FAU - Tilea, Ioan
AU  - Tilea I
AUID- ORCID: 0000-0002-3828-1499
AD  - Department of Internal Medicine, "George Emil Palade" University of Medicine, 
      Pharmacy, Science and Technology of Targu Mures, Targu Mures, 540142, Romania.
AD  - Department of Cardiology II, County Emergency Clinical Hospital, Targu Mures, 
      540042, Romania.
FAU - Petra, Dorina Nastasia
AU  - Petra DN
AD  - Department of Family Medicine, "George Emil Palade" University of Medicine, 
      Pharmacy, Science and Technology of Targu Mures, Targu Mures, 540142, Romania.
AD  - Department of Internal Medicine II, County Emergency Clinical Hospital, Targu 
      Mures, 540042, Romania.
FAU - Serban, Razvan Constantin
AU  - Serban RC
AD  - Cardiac Catheterization Laboratory, The Emergency Institute for Cardiovascular 
      Diseases and Transplantation, Targu Mures, 540136, Romania.
FAU - Gabor, Manuela Rozalia
AU  - Gabor MR
AD  - Department of Economics and Law, "George Emil Palade" University of Medicine, 
      Pharmacy, Science and Technology of Targu Mures, Targu Mures, 540142, Romania.
FAU - Tilinca, Mariana Cornelia
AU  - Tilinca MC
AD  - Department of Internal Medicine, "George Emil Palade" University of Medicine, 
      Pharmacy, Science and Technology of Targu Mures, Targu Mures, 540142, Romania.
FAU - Azamfirei, Leonard
AU  - Azamfirei L
AUID- ORCID: 0000-0003-3220-2267
AD  - Department of Anesthesiology and Intensive Care, "George Emil Palade" University 
      of Medicine, Pharmacy, Science and Technology of Targu Mures, Targu Mures, 
      540142, Romania.
AD  - Department of Anesthesiology and Intensive Care, County Emergency Clinical 
      Hospital, Targu Mures, 540042, Romania.
FAU - Varga, Andreea
AU  - Varga A
AUID- ORCID: 0000-0002-6395-9476
AD  - Department of Cardiology II, County Emergency Clinical Hospital, Targu Mures, 
      540042, Romania.
AD  - Department of Family Medicine, "George Emil Palade" University of Medicine, 
      Pharmacy, Science and Technology of Targu Mures, Targu Mures, 540142, Romania.
LA  - eng
PT  - Journal Article
DEP - 20210712
PL  - New Zealand
TA  - Int J Gen Med
JT  - International journal of general medicine
JID - 101515487
PMC - PMC8285229
OTO - NOTNLM
OT  - chronic thromboembolic pulmonary hypertension
OT  - ferritin
OT  - iron replenishment
OT  - pulmonary arterial hypertension
OT  - six-minute walk distance
COIS- The authors declare that they have no conflicts of interest related to this 
      study.
EDAT- 2021/07/22 06:00
MHDA- 2021/07/22 06:01
PMCR- 2021/07/12
CRDT- 2021/07/21 06:31
PHST- 2021/05/01 00:00 [received]
PHST- 2021/06/15 00:00 [accepted]
PHST- 2021/07/21 06:31 [entrez]
PHST- 2021/07/22 06:00 [pubmed]
PHST- 2021/07/22 06:01 [medline]
PHST- 2021/07/12 00:00 [pmc-release]
AID - 318343 [pii]
AID - 10.2147/IJGM.S318343 [doi]
PST - epublish
SO  - Int J Gen Med. 2021 Jul 12;14:3355-3366. doi: 10.2147/IJGM.S318343. eCollection 
      2021.