PMID- 34285891
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210722
IS  - 2288-176X (Print)
IS  - 2288-1778 (Electronic)
IS  - 2288-176X (Linking)
VI  - 17
IP  - 3
DP  - 2021 Jun
TI  - Treadmill exercise alleviates short-term memory impairments of pups born to old 
      and obese mother rats.
PG  - 153-157
LID - 10.12965/jer.2142300.150 [doi]
AB  - Obesity causes atrophy of the brain, leading to deterioration in working memory, 
      learning, and cognitive function. The status of short-term memory in rat pups 
      born to older obese mother rats was verified, and the effect of treadmill 
      exercise on short-term memory in rat pups was investigated. Step-down avoidance 
      test for short-term memory, terminal deoxynucleotidyl transferase-mediated dUTP 
      nick end labeling (TUNEL) staining for apoptosis, and immunohistochemistry for 
      Ki67 for new cell generation were done. The old female rats were fed with normal 
      diet (5% of fat), and the old and obese female rats were fed with high-fat diet 
      (60% of fat) for up to 50 weeks in age (for 44 weeks in experimental period). The 
      newborn rats were divided into four groups according to the conditions of the 
      mother rats as follows: the rat pups group born to old rats, the rat pups group 
      born to old rats with exercise, the rat pups group born to old and obese rats, 
      the rat pups group born to old and obese rats with exercise. Maternal exercise 
      improved short-term memory, decreased TUNEL-positive cell number, and increased 
      Ki67-positive cell number of the pups born to old and obese rats. Maternal 
      exercise has been found to contribute to eliminating the health risks of fetuses 
      born to old obese mothers.
CI  - Copyright (c) 2021 Korean Society of Exercise Rehabilitation.
FAU - Ko, Young Jun
AU  - Ko YJ
AUID- ORCID: 0000-0001-5469-7235
AD  - Major in Sport Service Practice, College of Welfare Convergence, Kangnam 
      University, Yongin, Korea.
LA  - eng
PT  - Journal Article
DEP - 20210630
PL  - Korea (South)
TA  - J Exerc Rehabil
JT  - Journal of exercise rehabilitation
JID - 101615171
PMC - PMC8257433
OTO - NOTNLM
OT  - Apoptosis
OT  - New cell generation
OT  - Older obese mother rats
OT  - Pups
OT  - Short-term memory
OT  - Treadmill exercise
COIS- CONFLICT OF INTEREST No potential conflict of interest relevant to this article 
      was reported.
EDAT- 2021/07/22 06:00
MHDA- 2021/07/22 06:01
PMCR- 2021/06/30
CRDT- 2021/07/21 06:36
PHST- 2021/04/16 00:00 [received]
PHST- 2021/05/19 00:00 [accepted]
PHST- 2021/07/21 06:36 [entrez]
PHST- 2021/07/22 06:00 [pubmed]
PHST- 2021/07/22 06:01 [medline]
PHST- 2021/06/30 00:00 [pmc-release]
AID - jer-17-3-153 [pii]
AID - 10.12965/jer.2142300.150 [doi]
PST - epublish
SO  - J Exerc Rehabil. 2021 Jun 30;17(3):153-157. doi: 10.12965/jer.2142300.150. 
      eCollection 2021 Jun.