PMID- 34286837
OWN - NLM
STAT- MEDLINE
DCOM- 20211210
LR  - 20211218
IS  - 1945-7197 (Electronic)
IS  - 0021-972X (Linking)
VI  - 106
IP  - 11
DP  - 2021 Oct 21
TI  - Branched-chain Amino Acids and Relationship With Inflammation in Youth With 
      Obesity: A Randomized Controlled Intervention Study.
PG  - 3129-3139
LID - 10.1210/clinem/dgab538 [doi]
AB  - CONTEXT: Elevated concentrations of branched-chain amino acids (BCAA) are strong 
      predictors of type 2 diabetes mellitus (T2DM). Their association with 
      cardiovascular disease (CVD) remains uncertain, particularly in youth. OBJECTIVE: 
      We investigated the role of BCAA and aromatic amino acids (AAA) in obesity, their 
      relationships with novel biomarkers of CVD, and response to a physical 
      activity-based lifestyle intervention (PAL-I) in a randomized controlled study in 
      youth with normal weight (NW) and obesity (OB). METHODS: Age (14-18 years) and 
      Tanner stage (>/=IV) matched youth (OB, n = 15 and NW, n = 6) were studied; the 15 
      participants with OB underwent a 3-month randomized controlled PAL-I. Circulating 
      amino acid profile, glucose, insulin, lipids, adiponectin, retinol binding 
      protein-4, fibrinogen, high-sensitivity C-reactive protein, interleukin-6, and 
      25-hydroxy vitamin-D, along with body composition, were measured at baseline and 
      after PAL-I. Independent t tests, analysis of covariance, and mixed-effect models 
      were used for analysis of the data. RESULTS: Compared with NW, the concentration 
      of various amino acids, including BCAA and AAA, were altered in OB (P < 0.05). 
      BCAA and AAA showed baseline correlations with body composition and novel 
      biomarkers of CVD, particularly inflammatory factors (all P < 0.05). The PAL-I 
      produced only negligible effects (P > 0.05) on BCAA and AAA. Glutamine, glycine, 
      and aspartic acid decreased with PAL-I (all P < 0.05). CONCLUSION: The novel 
      finding of the BCAA-inflammation relationship, along with strong correlations 
      with nontraditional biomarkers of CVD, may raise the prospect of BCAA as a 
      biomarker of CVD and evoke a potential link between obesity, T2DM, and CVD.
CI  - (c) The Author(s) 2021. Published by Oxford University Press on behalf of the 
      Endocrine Society. All rights reserved. For permissions, please e-mail: 
      journals.permissions@oup.com.
FAU - Cosentino, Ralph G
AU  - Cosentino RG
AD  - Department of Clinical and Applied Movement Sciences, University of North 
      Florida, Jacksonville, FL 32224, USA.
FAU - Churilla, James R
AU  - Churilla JR
AD  - Department of Clinical and Applied Movement Sciences, University of North 
      Florida, Jacksonville, FL 32224, USA.
FAU - Josephson, Samantha
AU  - Josephson S
AD  - Biomedical Research, Nemours Children's Health System, Jacksonville, FL 32207, 
      USA.
FAU - Molle-Rios, Zarela
AU  - Molle-Rios Z
AD  - Division of Gastroenterology, Nemours Children's Health System, Wilmington, DE 
      19802, USA.
FAU - Hossain, Md Jobayer
AU  - Hossain MJ
AD  - Biomedical Research, Nemours Children's Health System, Wilmington, DE 19802, USA.
FAU - Prado, Wagner L
AU  - Prado WL
AD  - Department of Kinesiology, California State University, San Bernardino, CA 92407, 
      USA.
FAU - Balagopal, P Babu
AU  - Balagopal PB
AUID- ORCID: 0000-0001-6940-0772
AD  - Biomedical Research, Nemours Children's Health System, Jacksonville, FL 32207, 
      USA.
AD  - Department of Pediatrics, Mayo Clinic College of Medicine, Rochester, MN 55905, 
      USA.
LA  - eng
SI  - ClinicalTrials.gov/NCT02613741
PT  - Journal Article
PT  - Observational Study
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Clin Endocrinol Metab
JT  - The Journal of clinical endocrinology and metabolism
JID - 0375362
RN  - 0 (Amino Acids, Branched-Chain)
RN  - 0 (Biomarkers)
SB  - IM
CIN - J Clin Endocrinol Metab. 2022 Jan 1;107(1):e420-e422. PMID: 34448488
MH  - Adolescent
MH  - Amino Acids, Branched-Chain/*metabolism
MH  - Biomarkers/*metabolism
MH  - Body Composition
MH  - Cardiovascular Diseases/etiology/metabolism/*pathology
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Inflammation/epidemiology/metabolism/*pathology
MH  - *Insulin Resistance
MH  - Male
MH  - Obesity/metabolism/*physiopathology
MH  - Prognosis
MH  - Risk Factors
MH  - United States/epidemiology
OTO - NOTNLM
OT  - biomarkers
OT  - branched-chain amino acids
OT  - cardiovascular disease
OT  - children
OT  - nutrition
OT  - obesity
EDAT- 2021/07/22 06:00
MHDA- 2021/12/15 06:00
CRDT- 2021/07/21 09:17
PHST- 2021/04/13 00:00 [received]
PHST- 2021/07/22 06:00 [pubmed]
PHST- 2021/12/15 06:00 [medline]
PHST- 2021/07/21 09:17 [entrez]
AID - 6324841 [pii]
AID - 10.1210/clinem/dgab538 [doi]
PST - ppublish
SO  - J Clin Endocrinol Metab. 2021 Oct 21;106(11):3129-3139. doi: 
      10.1210/clinem/dgab538.