PMID- 34287233
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210723
IS  - 2409-515X (Electronic)
IS  - 2409-515X (Linking)
VI  - 7
IP  - 3
DP  - 2021 Jul 8
TI  - Newborn Screening for Severe Combined Immunodeficiency: Do Preterm Infants 
      Require Special Consideration?
LID - 10.3390/ijns7030040 [doi]
LID - 40
AB  - The Wisconsin Newborn Screening (NBS) Program began screening for severe combined 
      immunodeficiency (SCID) in 2008, using real-time PCR to quantitate T-cell 
      receptor excision circles (TRECs) in DNA isolated from dried blood NBS specimens. 
      Prompted by the observation that there were disproportionately more 
      screening-positive cases in premature infants, we performed a study to assess 
      whether there is a difference in TRECs between full-term and preterm newborns. 
      Based on de-identified SCID data from 1 January to 30 June 2008, we evaluated the 
      TRECs from 2510 preterm newborns (gestational age, 23-36 weeks) whose specimens 
      were collected </=72 h after birth. The TRECs from 5020 full-term newborns were 
      included as controls. The relationship between TRECs and gestational age in weeks 
      was estimated using linear regression analysis. The estimated increase in TRECs 
      for every additional week of gestation is 9.60%. The 95% confidence interval is 
      8.95% to 10.25% (p </= 0.0001). Our data suggest that TRECs increase at a steady 
      rate as gestational age increases. These results provide rationale for 
      Wisconsin's existing premature infant screening procedure of recommending repeat 
      NBS following an SCID screening positive in a premature infant instead of the 
      flow cytometry confirmatory testing for SCID screening positives in full-term 
      infants.
FAU - Atkins, Anne E
AU  - Atkins AE
AUID- ORCID: 0000-0002-5284-6089
AD  - Wisconsin State Laboratory of Hygiene, University of Wisconsin School of Medicine 
      and Public Health, Madison, WI 53706, USA.
FAU - Cogley, Michael F
AU  - Cogley MF
AD  - Wisconsin State Laboratory of Hygiene, University of Wisconsin School of Medicine 
      and Public Health, Madison, WI 53706, USA.
FAU - Baker, Mei W
AU  - Baker MW
AUID- ORCID: 0000-0002-8707-1834
AD  - Wisconsin State Laboratory of Hygiene, University of Wisconsin School of Medicine 
      and Public Health, Madison, WI 53706, USA.
AD  - Genetics and Metabolism Division, Department of Pediatrics, University of 
      Wisconsin School of Medicine and Public Health, Madison, WI 53706, USA.
AD  - Center for Human Genomics and Precision Medicine, University of Wisconsin School 
      of Medicine and Public Health, Madison, WI 53706, USA.
LA  - eng
PT  - Journal Article
DEP - 20210708
PL  - Switzerland
TA  - Int J Neonatal Screen
JT  - International journal of neonatal screening
JID - 101665400
PMC - PMC8293075
OTO - NOTNLM
OT  - T-cell receptor excision circles (TRECs)
OT  - gestational age
OT  - newborn screening (NBS)
OT  - premature newborns
OT  - severe combined immunodeficiency (SCID)
COIS- The authors declare no conflict of interest.
EDAT- 2021/07/22 06:00
MHDA- 2021/07/22 06:01
PMCR- 2021/07/08
CRDT- 2021/07/21 12:45
PHST- 2021/05/29 00:00 [received]
PHST- 2021/07/01 00:00 [revised]
PHST- 2021/07/05 00:00 [accepted]
PHST- 2021/07/21 12:45 [entrez]
PHST- 2021/07/22 06:00 [pubmed]
PHST- 2021/07/22 06:01 [medline]
PHST- 2021/07/08 00:00 [pmc-release]
AID - ijns7030040 [pii]
AID - IJNS-07-00040 [pii]
AID - 10.3390/ijns7030040 [doi]
PST - epublish
SO  - Int J Neonatal Screen. 2021 Jul 8;7(3):40. doi: 10.3390/ijns7030040.