PMID- 34288499
OWN - NLM
STAT- MEDLINE
DCOM- 20220223
LR  - 20231108
IS  - 1860-7187 (Electronic)
IS  - 1860-7179 (Print)
IS  - 1860-7179 (Linking)
VI  - 16
IP  - 20
DP  - 2021 Oct 15
TI  - Synthesis and Antimicrobial Evaluation of Bis-morpholine Triazine Quaternary 
      Ammonium Salts.
PG  - 3172-3176
LID - 10.1002/cmdc.202100409 [doi]
AB  - Efficient, environmentally and economically sustainable, and nontoxic 
      antibacterial products are of global relevance in the fight against microorganism 
      contamination. In this work, an easy and straightforward method for the synthesis 
      of bis-morpholino triazine quaternary ammonium salts (bis-mTQAS) is reported, 
      starting from 2,4,6-trichloro-1,3,5-triazine or 
      2,4-dichloro-6-methoxy-1,3,5-triazine and various N-alkylmorpholines. Bis-mTQAS 
      were tested as antimicrobials against Gram-negative and Gram-positive bacterial 
      strains. The best-performing bis-mTQAS were found to achieve total disinfection 
      against Staphylococcus aureus ATCC 25923 and Escherichia coli ATCC 25922 at 50 
      and 400 mug/mL, respectively. Distinctively, bis-mTQAS with the highest 
      antimicrobial efficiency had lowest cytotoxicity.
CI  - (c) 2021 The Authors. ChemMedChem published by Wiley-VCH GmbH.
FAU - Morandini, Andrea
AU  - Morandini A
AD  - Dipartimento di Scienze Molecolari e Nanosistemi, Universita Ca' Foscari di 
      Venezia, Via Torino 155, 30172, Venezia Mestre, Italy.
FAU - Leonetti, Benedetta
AU  - Leonetti B
AD  - Brenta S.r.l. - Nine trees group, Viale Milano 26, 36075, Montecchio Maggiore, 
      Vicenza, Italy.
FAU - Riello, Pietro
AU  - Riello P
AD  - Dipartimento di Scienze Molecolari e Nanosistemi, Universita Ca' Foscari di 
      Venezia, Via Torino 155, 30172, Venezia Mestre, Italy.
AD  - European Centre for Living Technology (ECLT) Ca' Bottacin, Dorsoduro 3911, 30123, 
      Venice, Italy.
FAU - Sole, Roberto
AU  - Sole R
AD  - Dipartimento di Scienze Molecolari e Nanosistemi, Universita Ca' Foscari di 
      Venezia, Via Torino 155, 30172, Venezia Mestre, Italy.
AD  - CIRCC, Via C. Ulpiani 27, 70126, Bari, Italy.
FAU - Gatto, Vanessa
AU  - Gatto V
AD  - Dipartimento di Scienze Molecolari e Nanosistemi, Universita Ca' Foscari di 
      Venezia, Via Torino 155, 30172, Venezia Mestre, Italy.
AD  - Crossing S.r.l., Viale della Repubblica 193/b, 31100, Treviso, Italy.
FAU - Caligiuri, Isabella
AU  - Caligiuri I
AD  - Pathology Unit, Centro di Riferimento Oncologico (CRO) IRCCS, Via F. Gallini 2, 
      33081, Aviano, Italy.
FAU - Rizzolio, Flavio
AU  - Rizzolio F
AD  - Dipartimento di Scienze Molecolari e Nanosistemi, Universita Ca' Foscari di 
      Venezia, Via Torino 155, 30172, Venezia Mestre, Italy.
AD  - Pathology Unit, Centro di Riferimento Oncologico (CRO) IRCCS, Via F. Gallini 2, 
      33081, Aviano, Italy.
FAU - Beghetto, Valentina
AU  - Beghetto V
AUID- ORCID: 0000-0001-8799-210X
AD  - Dipartimento di Scienze Molecolari e Nanosistemi, Universita Ca' Foscari di 
      Venezia, Via Torino 155, 30172, Venezia Mestre, Italy.
AD  - Crossing S.r.l., Viale della Repubblica 193/b, 31100, Treviso, Italy.
LA  - eng
PT  - Journal Article
DEP - 20210729
PL  - Germany
TA  - ChemMedChem
JT  - ChemMedChem
JID - 101259013
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Morpholines)
RN  - 0 (Quaternary Ammonium Compounds)
RN  - 0 (Salts)
RN  - 0 (Triazines)
SB  - IM
MH  - Anti-Bacterial Agents/chemical synthesis/chemistry/*pharmacology
MH  - Dose-Response Relationship, Drug
MH  - Escherichia coli/*drug effects
MH  - Microbial Sensitivity Tests
MH  - Molecular Structure
MH  - Morpholines/chemistry/*pharmacology
MH  - Quaternary Ammonium Compounds/chemistry/*pharmacology
MH  - Salts/chemistry/pharmacology
MH  - Staphylococcus aureus/*drug effects
MH  - Structure-Activity Relationship
MH  - Triazines/chemistry/*pharmacology
PMC - PMC8596621
OTO - NOTNLM
OT  - QAS
OT  - antimicrobial agents
OT  - low toxicity antimicrobials
OT  - triazine quaternary ammonium salts
COIS- The authors declare no conflict of interest.
EDAT- 2021/07/22 06:00
MHDA- 2022/02/24 06:00
PMCR- 2021/11/17
CRDT- 2021/07/21 13:49
PHST- 2021/07/18 00:00 [revised]
PHST- 2021/06/07 00:00 [received]
PHST- 2021/07/22 06:00 [pubmed]
PHST- 2022/02/24 06:00 [medline]
PHST- 2021/07/21 13:49 [entrez]
PHST- 2021/11/17 00:00 [pmc-release]
AID - CMDC202100409 [pii]
AID - 10.1002/cmdc.202100409 [doi]
PST - ppublish
SO  - ChemMedChem. 2021 Oct 15;16(20):3172-3176. doi: 10.1002/cmdc.202100409. Epub 2021 
      Jul 29.