PMID- 342888 OWN - NLM STAT- MEDLINE DCOM- 19780417 LR - 20191021 IS - 0300-8584 (Print) IS - 0300-8584 (Linking) VI - 163 IP - 4 DP - 1977 Dec 27 TI - Serum immunoglobulin E level and search for myelin basic protein specific IgE antibodies in patients with multiple sclerosis. PG - 227-32 AB - Circulating levels of immunoglobulin E (IgE) have been determined by solid-phase radioimmunoassay in groups of patients with different clinical courses of multiple sclerosis (MS) and in healthy controls. The geometric mean of the serum IgE level in the MS patients was somewhat less than that in the control group (64 U/ml), but this decrease was not significant. Contrary to the findings of Campbell [1, 2, 3, 4], circulating IgE in the MS patients was not specifically adsorbed on bovine myelin basic protein (BMBP) immunoadsorbent and does not give a positive immunofluorescence using guinea pig brain sections. FAU - Barsoum, A L AU - Barsoum AL FAU - Hoher, P G AU - Hoher PG FAU - Kuwert, E K AU - Kuwert EK LA - eng PT - Comparative Study PT - Journal Article PL - Germany TA - Med Microbiol Immunol JT - Medical microbiology and immunology JID - 0314524 RN - 0 (Antibodies) RN - 0 (Immunoglobulin G) RN - 0 (Myelin Proteins) RN - 37341-29-0 (Immunoglobulin E) SB - IM MH - Adult MH - Animals MH - Antibodies/*analysis MH - Antibody Specificity MH - Cattle MH - Fluorescent Antibody Technique MH - Humans MH - Immunoglobulin E/*analysis MH - Immunoglobulin G/analysis MH - Immunosorbent Techniques MH - Multiple Sclerosis/*immunology/pathology MH - Myelin Proteins/*immunology MH - Radioimmunoassay EDAT- 1977/12/27 00:00 MHDA- 1977/12/27 00:01 CRDT- 1977/12/27 00:00 PHST- 1977/12/27 00:00 [pubmed] PHST- 1977/12/27 00:01 [medline] PHST- 1977/12/27 00:00 [entrez] AID - 10.1007/BF02125506 [doi] PST - ppublish SO - Med Microbiol Immunol. 1977 Dec 27;163(4):227-32. doi: 10.1007/BF02125506.