PMID- 34289534
OWN - NLM
STAT- MEDLINE
DCOM- 20211117
LR  - 20221005
IS  - 2050-4527 (Electronic)
IS  - 2050-4527 (Linking)
VI  - 9
IP  - 4
DP  - 2021 Dec
TI  - High-resolution HLA genotyping identifies alleles associated with severe 
      COVID-19: A preliminary study from India.
PG  - 1781-1785
LID - 10.1002/iid3.481 [doi]
AB  - INTRODUCTION: Human leukocyte antigen (HLA) variability has been demonstrated to 
      be associated with susceptibility/severity of COVID-19. High-resolution HLA 
      genotyping to identify alleles associated with severe COVID-19 in an Indian 
      cohort was performed. METHODS: Quantitative reverse-transcription polymerase 
      chain reaction-confirmed SARS-CoV-2-positive patients with mild/moderate/severe 
      disease (n = 54) and asymptomatic (n = 42) were recruited and genotyped for 
      11-HLA loci on MiSeq using NGSgo(R)-MX11-3 and analyzed (NGSengine; GenDx). 
      RESULTS: A significant difference in alleles between the groups was identified 
      for HLA-C*04:01:01:01, HLA-DRB5*01:01:01:02, HLA-DQA1*03:01:01:01, 
      HLA-DPB1*04:01:01:41, and HLA-DPA1*01:03:01:02. Alleles namely, HLA-C*04:01:01:01 
      (OR: 5.71; 95% CI: 1.2-27.14; p = .02), HLA-DRB5*01:01:01:02 (OR: 2.94; 95% CI: 
      1.1-7.84; p = .03), DQA1*03:01:01:01 (OR: 22.47; 95% CI: 1.28-393.5; p = .03), 
      HLA-DPB1*04:01:01:41 (OR: 9.44; 95% CI: 0.5-175.81; p = .13), and 
      HLA-DPA1*01:03:01:02 (OR: 8.27; 95% CI: 2.26-30.21; p = .001) were associated 
      with severe COVID-19. CONCLUSION: Genotyping for these alleles will enable 
      identification of individuals at risk of severe disease and stratification for 
      preferential vaccination.
CI  - (c) 2021 The Authors. Immunity, Inflammation and Disease published by John Wiley & 
      Sons Ltd.
FAU - Vishnubhotla, Ravikanth
AU  - Vishnubhotla R
AUID- ORCID: 0000-0001-6970-0169
AD  - Asian Healthcare Foundation/AIG Hospitals, Hyderabad, Telangana, India.
FAU - Sasikala, Mitnala
AU  - Sasikala M
AUID- ORCID: 0000-0002-3785-0530
AD  - Asian Healthcare Foundation/AIG Hospitals, Hyderabad, Telangana, India.
FAU - Ketavarapu, Vijayasarathy
AU  - Ketavarapu V
AD  - Asian Healthcare Foundation/AIG Hospitals, Hyderabad, Telangana, India.
FAU - Reddy, Duvvur Nageshwar
AU  - Reddy DN
AUID- ORCID: 0000-0001-7540-0496
AD  - Asian Healthcare Foundation/AIG Hospitals, Hyderabad, Telangana, India.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210721
PL  - England
TA  - Immun Inflamm Dis
JT  - Immunity, inflammation and disease
JID - 101635460
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Alleles
MH  - *COVID-19
MH  - Genotype
MH  - HLA Antigens
MH  - Humans
MH  - SARS-CoV-2
PMC - PMC8426675
OTO - NOTNLM
OT  - COVID-19
OT  - HLA genotyping
OT  - SARS-CoV-2
OT  - severe COVID-19
OT  - vaccination
COIS- The authors declare that there are no conflict of interests.
EDAT- 2021/07/22 06:00
MHDA- 2021/11/18 06:00
PMCR- 2021/07/21
CRDT- 2021/07/21 20:13
PHST- 2021/06/07 00:00 [revised]
PHST- 2021/05/04 00:00 [received]
PHST- 2021/06/21 00:00 [accepted]
PHST- 2021/07/22 06:00 [pubmed]
PHST- 2021/11/18 06:00 [medline]
PHST- 2021/07/21 20:13 [entrez]
PHST- 2021/07/21 00:00 [pmc-release]
AID - IID3481 [pii]
AID - 10.1002/iid3.481 [doi]
PST - ppublish
SO  - Immun Inflamm Dis. 2021 Dec;9(4):1781-1785. doi: 10.1002/iid3.481. Epub 2021 Jul 
      21.