PMID- 34290309
OWN - NLM
STAT- MEDLINE
DCOM- 20211124
LR  - 20211124
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 11
IP  - 1
DP  - 2021 Jul 21
TI  - Impact of heat stress on embryonic development during first 16 days of gestation 
      in dairy cows.
PG  - 14839
LID - 10.1038/s41598-021-94278-2 [doi]
LID - 14839
AB  - Objective was to elucidate the effects of heat stress (HS) on embryo development 
      during first 16 gestational days (GD) and circulating hormone concentrations on 
      GD-16 in lactating Holstein cows. Cows in HS and control (CON) groups were 
      exposed to temperature humidity index (THI) of >/= 73 and < 73, respectively, for 
      3 weeks before the experiment. GD-7 (67 vs 49%) and GD-16 (52 vs. 31%) conception 
      rates following single insemination were greater (P < 0.01) for CON compared with 
      HS cows. Control cows produced more GD-7 transferrable embryos following 
      superovulation compared with HS cows (84.8 vs 53.1%; P < 0.001). Mean (+/- SEM) 
      length (45.2 +/- 10.6 vs. 59.2 +/- 9.1 mm) and weight (31.4 +/- 4.3 vs. 42.4 +/- 6.2 mg) 
      of GD-16 conceptus were greater for CON compared with HS cows (P < 0.05). Control 
      cows yielded more filamentous conceptus (>/= 25 mm) compared with HS cows (71 vs 
      45%; P < 0.05). Progesterone (2.09-fold) was higher, and cortisol (1.86-fold), 
      prolactin (1.60-fold), substance-P (1.55-fold), Isoprostane-8 (1.34-fold) and 
      prostaglandin F metabolites (1.97-fold) were lower in CON compared with HS cows 
      (P < 0.05). Progesterone positively, and substance-P, isoprostane-8 and the THI 
      negatively were associated with GD-16 conceptus length (P < 0.05). In conclusion, 
      altered hormones concentrations in heat-stressed cows plausibly resulted in lower 
      GD-7 and GD-16 conception rates, fewer GD-7 transferable embryos, and stunted 
      GD-16 conceptus elongation.
CI  - (c) 2021. The Author(s).
FAU - Kasimanickam, Ramanathan
AU  - Kasimanickam R
AD  - Department of Veterinary Clinical Sciences, College of Veterinary Medicine, 
      Washington State University, Pullman, WA, 99164, USA. ramkasi@wsu.edu.
FAU - Kasimanickam, Vanmathy
AU  - Kasimanickam V
AD  - Department of Veterinary Clinical Sciences, College of Veterinary Medicine, 
      Washington State University, Pullman, WA, 99164, USA.
AD  - AARVEE Animal Biotech LLC, Corvallis, OR, 97333, USA.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210721
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (Isoprostanes)
RN  - 0 (Prostaglandins F)
RN  - 33507-63-0 (Substance P)
RN  - 4G7DS2Q64Y (Progesterone)
RN  - 9002-62-4 (Prolactin)
RN  - WI4X0X7BPJ (Hydrocortisone)
SB  - IM
MH  - Animals
MH  - Cattle/*embryology/metabolism/*physiology
MH  - Embryonic Development/*physiology
MH  - Female
MH  - Gestational Age
MH  - Heat-Shock Response/*physiology
MH  - Hydrocortisone/metabolism
MH  - Isoprostanes/metabolism
MH  - Lactation
MH  - Pregnancy/*physiology
MH  - Progesterone/metabolism
MH  - Prolactin/metabolism
MH  - Prostaglandins F/metabolism
MH  - Substance P/metabolism
PMC - PMC8295254
COIS- The authors declare no competing interests.
EDAT- 2021/07/23 06:00
MHDA- 2021/11/25 06:00
PMCR- 2021/07/21
CRDT- 2021/07/22 06:08
PHST- 2021/01/31 00:00 [received]
PHST- 2021/07/07 00:00 [accepted]
PHST- 2021/07/22 06:08 [entrez]
PHST- 2021/07/23 06:00 [pubmed]
PHST- 2021/11/25 06:00 [medline]
PHST- 2021/07/21 00:00 [pmc-release]
AID - 10.1038/s41598-021-94278-2 [pii]
AID - 94278 [pii]
AID - 10.1038/s41598-021-94278-2 [doi]
PST - epublish
SO  - Sci Rep. 2021 Jul 21;11(1):14839. doi: 10.1038/s41598-021-94278-2.