PMID- 34290398
OWN - NLM
STAT- MEDLINE
DCOM- 20210921
LR  - 20220417
IS  - 2042-0226 (Electronic)
IS  - 1672-7681 (Print)
IS  - 1672-7681 (Linking)
VI  - 18
IP  - 9
DP  - 2021 Sep
TI  - Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection.
PG  - 2128-2139
LID - 10.1038/s41423-021-00728-2 [doi]
AB  - Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV)-2 infection induces an 
      exacerbated inflammation driven by innate immunity components. Dendritic cells 
      (DCs) play a key role in the defense against viral infections, for instance 
      plasmacytoid DCs (pDCs), have the capacity to produce vast amounts of 
      interferon-alpha (IFN-alpha). In COVID-19 there is a deficit in DC numbers and IFN-alpha 
      production, which has been associated with disease severity. In this work, we 
      described that in addition to the DC deficiency, several DC activation and homing 
      markers were altered in acute COVID-19 patients, which were associated with 
      multiple inflammatory markers. Remarkably, previously hospitalized and 
      nonhospitalized patients remained with decreased numbers of CD1c+ myeloid DCs and 
      pDCs seven months after SARS-CoV-2 infection. Moreover, the expression of DC 
      markers such as CD86 and CD4 were only restored in previously nonhospitalized 
      patients, while no restoration of integrin beta7 and indoleamine 2,3-dyoxigenase 
      (IDO) levels were observed. These findings contribute to a better understanding 
      of the immunological sequelae of COVID-19.
CI  - (c) 2021. The Author(s), under exclusive licence to CSI and USTC.
FAU - Perez-Gomez, Alberto
AU  - Perez-Gomez A
AD  - Clinical Unit of Infectious Diseases, Microbiology and Preventive Medicine, 
      Institute of Biomedicine of Seville (IBiS), Virgen del Rocio University Hospital, 
      CSIC, University of Seville, Seville, Spain.
FAU - Vitalle, Joana
AU  - Vitalle J
AD  - Clinical Unit of Infectious Diseases, Microbiology and Preventive Medicine, 
      Institute of Biomedicine of Seville (IBiS), Virgen del Rocio University Hospital, 
      CSIC, University of Seville, Seville, Spain.
FAU - Gasca-Capote, Carmen
AU  - Gasca-Capote C
AD  - Clinical Unit of Infectious Diseases, Microbiology and Preventive Medicine, 
      Institute of Biomedicine of Seville (IBiS), Virgen del Rocio University Hospital, 
      CSIC, University of Seville, Seville, Spain.
FAU - Gutierrez-Valencia, Alicia
AU  - Gutierrez-Valencia A
AD  - Clinical Unit of Infectious Diseases, Microbiology and Preventive Medicine, 
      Institute of Biomedicine of Seville (IBiS), Virgen del Rocio University Hospital, 
      CSIC, University of Seville, Seville, Spain.
FAU - Trujillo-Rodriguez, Maria
AU  - Trujillo-Rodriguez M
AD  - Clinical Unit of Infectious Diseases, Microbiology and Preventive Medicine, 
      Institute of Biomedicine of Seville (IBiS), Virgen del Rocio University Hospital, 
      CSIC, University of Seville, Seville, Spain.
FAU - Serna-Gallego, Ana
AU  - Serna-Gallego A
AD  - Clinical Unit of Infectious Diseases, Microbiology and Preventive Medicine, 
      Institute of Biomedicine of Seville (IBiS), Virgen del Rocio University Hospital, 
      CSIC, University of Seville, Seville, Spain.
FAU - Munoz-Muela, Esperanza
AU  - Munoz-Muela E
AD  - Clinical Unit of Infectious Diseases, Microbiology and Preventive Medicine, 
      Institute of Biomedicine of Seville (IBiS), Virgen del Rocio University Hospital, 
      CSIC, University of Seville, Seville, Spain.
FAU - Jimenez-Leon, Maria de Los Reyes
AU  - Jimenez-Leon MLR
AD  - Clinical Unit of Infectious Diseases, Microbiology and Preventive Medicine, 
      Institute of Biomedicine of Seville (IBiS), Virgen del Rocio University Hospital, 
      CSIC, University of Seville, Seville, Spain.
FAU - Rafii-El-Idrissi Benhnia, Mohamed
AU  - Rafii-El-Idrissi Benhnia M
AD  - Clinical Unit of Infectious Diseases, Microbiology and Preventive Medicine, 
      Institute of Biomedicine of Seville (IBiS), Virgen del Rocio University Hospital, 
      CSIC, University of Seville, Seville, Spain.
AD  - Department of Medical Biochemistry, Molecular Biology, and Immunology, School of 
      Medicine, University of Seville, Seville, Spain.
FAU - Rivas-Jeremias, Inmaculada
AU  - Rivas-Jeremias I
AD  - Clinical Unit of Infectious Diseases, Microbiology and Preventive Medicine, 
      Institute of Biomedicine of Seville (IBiS), Virgen del Rocio University Hospital, 
      CSIC, University of Seville, Seville, Spain.
FAU - Sotomayor, Cesar
AU  - Sotomayor C
AD  - Clinical Unit of Infectious Diseases, Microbiology and Preventive Medicine, 
      Institute of Biomedicine of Seville (IBiS), Virgen del Rocio University Hospital, 
      CSIC, University of Seville, Seville, Spain.
FAU - Roca-Oporto, Cristina
AU  - Roca-Oporto C
AD  - Clinical Unit of Infectious Diseases, Microbiology and Preventive Medicine, 
      Institute of Biomedicine of Seville (IBiS), Virgen del Rocio University Hospital, 
      CSIC, University of Seville, Seville, Spain.
FAU - Espinosa, Nuria
AU  - Espinosa N
AD  - Clinical Unit of Infectious Diseases, Microbiology and Preventive Medicine, 
      Institute of Biomedicine of Seville (IBiS), Virgen del Rocio University Hospital, 
      CSIC, University of Seville, Seville, Spain.
FAU - Infante-Dominguez, Carmen
AU  - Infante-Dominguez C
AD  - Clinical Unit of Infectious Diseases, Microbiology and Preventive Medicine, 
      Institute of Biomedicine of Seville (IBiS), Virgen del Rocio University Hospital, 
      CSIC, University of Seville, Seville, Spain.
FAU - Crespo-Rivas, Juan Carlos
AU  - Crespo-Rivas JC
AD  - Clinical Unit of Infectious Diseases, Microbiology and Preventive Medicine, 
      Institute of Biomedicine of Seville (IBiS), Virgen del Rocio University Hospital, 
      CSIC, University of Seville, Seville, Spain.
FAU - Fernandez-Villar, Alberto
AU  - Fernandez-Villar A
AD  - Pneumology Service, Galicia Sur Health Research Instituto (IIS Galicia Sur), 
      SERGAS-UVigo, Vigo, Spain.
FAU - Perez-Gonzalez, Alexandre
AU  - Perez-Gonzalez A
AD  - Infectious Diseases Unit, Department of Internal Medicine, Complexo 
      HospitalarioUniversitario de Vigo, IIS Galicia Sur, SERGAS-UVigo, Vigo, Spain.
AD  - Group of Virology and Pathogenesis, Galicia Sur Health Research Institute (IIS 
      Galicia Sur)-Complexo Hospitalario Universitario de Vigo, SERGAS-UVigo, Vigo, 
      Spain.
FAU - Lopez-Cortes, Luis Fernando
AU  - Lopez-Cortes LF
AD  - Clinical Unit of Infectious Diseases, Microbiology and Preventive Medicine, 
      Institute of Biomedicine of Seville (IBiS), Virgen del Rocio University Hospital, 
      CSIC, University of Seville, Seville, Spain.
FAU - Poveda, Eva
AU  - Poveda E
AD  - Group of Virology and Pathogenesis, Galicia Sur Health Research Institute (IIS 
      Galicia Sur)-Complexo Hospitalario Universitario de Vigo, SERGAS-UVigo, Vigo, 
      Spain.
FAU - Ruiz-Mateos, Ezequiel
AU  - Ruiz-Mateos E
AD  - Clinical Unit of Infectious Diseases, Microbiology and Preventive Medicine, 
      Institute of Biomedicine of Seville (IBiS), Virgen del Rocio University Hospital, 
      CSIC, University of Seville, Seville, Spain. eruizmateos-ibis@us.es.
CN  - Virgen del Rocio Hospital COVID-19 Working Team
LA  - eng
GR  - CM20/00243/Ministry of Economy and Competitiveness | Instituto de Salud Carlos 
      III (Institute of Health Carlos III)/
GR  - FI19/00083/Ministry of Economy and Competitiveness | Instituto de Salud Carlos 
      III (Institute of Health Carlos III)/
GR  - CP19/00159/Ministry of Economy and Competitiveness | Instituto de Salud Carlos 
      III (Institute of Health Carlos III)/
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210721
PL  - China
TA  - Cell Mol Immunol
JT  - Cellular & molecular immunology
JID - 101242872
RN  - 0 (Interferon-alpha)
SB  - IM
MH  - COVID-19/*immunology
MH  - Cells, Cultured
MH  - Dendritic Cells/*immunology
MH  - Female
MH  - Humans
MH  - Immunity, Innate/immunology
MH  - Inflammation/immunology
MH  - Interferon-alpha/immunology
MH  - Leukocytes, Mononuclear/immunology
MH  - Male
MH  - SARS-CoV-2/*immunology
MH  - Severity of Illness Index
PMC - PMC8294321
OTO - NOTNLM
OT  - COVID-19
OT  - Dendritic cell
OT  - Long-COVID
OT  - SARS-CoV-2
COIS- The authors declare no competing interests.
FIR - Cisneros, Jose Miguel
IR  - Cisneros JM
FIR - Salto-Alejandre, Sonsoles
IR  - Salto-Alejandre S
FIR - Berastegui-Cabrera, Judith
IR  - Berastegui-Cabrera J
FIR - Camacho-Martinez, Pedro
IR  - Camacho-Martinez P
FIR - Infante-Dominguez, Carmen
IR  - Infante-Dominguez C
FIR - Carretero-Ledesma, Marta
IR  - Carretero-Ledesma M
FIR - Crespo-Rivas, Juan Carlos
IR  - Crespo-Rivas JC
FIR - Marquez, Eduardo
IR  - Marquez E
FIR - Lomas, Jose Manuel
IR  - Lomas JM
FIR - Bueno, Claudio
IR  - Bueno C
FIR - Amaya, Rosario
IR  - Amaya R
FIR - Lepe, Jose Antonio
IR  - Lepe JA
FIR - Pachon, Jeronimo
IR  - Pachon J
FIR - Cordero, Elisa
IR  - Cordero E
FIR - Sanchez-Cespedes, Javier
IR  - Sanchez-Cespedes J
FIR - Aguilar-Guisado, Manuela
IR  - Aguilar-Guisado M
FIR - Aguilera, Almudena
IR  - Aguilera A
FIR - Aguilera, Clara
IR  - Aguilera C
FIR - Aldabo-Pallas, Teresa
IR  - Aldabo-Pallas T
FIR - Alfaro-Lara, Veronica
IR  - Alfaro-Lara V
FIR - Amodeo, Cristina
IR  - Amodeo C
FIR - Ampuero, Javier
IR  - Ampuero J
FIR - Aviles, Maria Dolores
IR  - Aviles MD
FIR - Asensio, Maribel
IR  - Asensio M
FIR - Baron-Franco, Bosco
IR  - Baron-Franco B
FIR - Barrera-Pulido, Lydia
IR  - Barrera-Pulido L
FIR - Bellido-Alba, Rafael
IR  - Bellido-Alba R
FIR - Bernabeu-Wittel, Maximo
IR  - Bernabeu-Wittel M
FIR - Caballero-Eraso, Candela
IR  - Caballero-Eraso C
FIR - Cabrera, Macarena
IR  - Cabrera M
FIR - Calderon, Enrique
IR  - Calderon E
FIR - Carbajal-Guerrero, Jesus
IR  - Carbajal-Guerrero J
FIR - Cid-Cumplido, Manuela
IR  - Cid-Cumplido M
FIR - Corcia-Palomo, Yael
IR  - Corcia-Palomo Y
FIR - Delgado, Juan
IR  - Delgado J
FIR - Dominguez-Petit, Antonio
IR  - Dominguez-Petit A
FIR - Deniz, Alejandro
IR  - Deniz A
FIR - Dusseck-Brutus, Reginal
IR  - Dusseck-Brutus R
FIR - Escoresca-Ortega, Ana
IR  - Escoresca-Ortega A
FIR - Espinosa, Fatima
IR  - Espinosa F
FIR - Espinosa, Nuria
IR  - Espinosa N
FIR - Espinoza, Michelle
IR  - Espinoza M
FIR - Ferrandiz-Millon, Carmen
IR  - Ferrandiz-Millon C
FIR - Ferrer, Marta
IR  - Ferrer M
FIR - Ferrer, Teresa
IR  - Ferrer T
FIR - Gallego-Texeira, Ignacio
IR  - Gallego-Texeira I
FIR - Gamez-Mancera, Rosa
IR  - Gamez-Mancera R
FIR - Garcia, Emilio
IR  - Garcia E
FIR - Garcia-Delgado, Horacio
IR  - Garcia-Delgado H
FIR - Garcia-Gutierrez, Manuel
IR  - Garcia-Gutierrez M
FIR - Gascon-Castillo, Maria Luisa
IR  - Gascon-Castillo ML
FIR - Gonzalez-Estrada, Aurora
IR  - Gonzalez-Estrada A
FIR - Gonzalez, Demetrio
IR  - Gonzalez D
FIR - Gomez-Gonzalez, Carmen
IR  - Gomez-Gonzalez C
FIR - Gonzalez-Leon, Rocio
IR  - Gonzalez-Leon R
FIR - Grande-Cabrerizo, Carmen
IR  - Grande-Cabrerizo C
FIR - Gutierrez, Sonia
IR  - Gutierrez S
FIR - Hernandez-Quiles, Carlos
IR  - Hernandez-Quiles C
FIR - Herrera-Melero, Inmaculada Concepcion
IR  - Herrera-Melero IC
FIR - Herrero-Romero, Marta
IR  - Herrero-Romero M
FIR - Jara, Luis
IR  - Jara L
FIR - Jimenez-Juan, Carlos
IR  - Jimenez-Juan C
FIR - Jimenez-Jorge, Silvia
IR  - Jimenez-Jorge S
FIR - Jimenez-Sanchez, Mercedes
IR  - Jimenez-Sanchez M
FIR - Lanseros-Tenllado, Julia
IR  - Lanseros-Tenllado J
FIR - Lopez, Carmina
IR  - Lopez C
FIR - Lopez, Isabel
IR  - Lopez I
FIR - Lopez-Barrios, Alvaro
IR  - Lopez-Barrios A
FIR - Lopez-Cortes, Luis F
IR  - Lopez-Cortes LF
FIR - Luque-Marquez, Rafael
IR  - Luque-Marquez R
FIR - Macias-Garcia, Daniel
IR  - Macias-Garcia D
FIR - Martin-Gutierrez, Guillermo
IR  - Martin-Gutierrez G
FIR - Martin-Villen, Luis
IR  - Martin-Villen L
FIR - Molina, Jose
IR  - Molina J
FIR - Morillo, Aurora
IR  - Morillo A
FIR - Navarro-Amuedo, Maria Dolores
IR  - Navarro-Amuedo MD
FIR - Nieto-Martin, Dolores
IR  - Nieto-Martin D
FIR - Ortega, Francisco
IR  - Ortega F
FIR - Paniagua-Garcia, Maria
IR  - Paniagua-Garcia M
FIR - Pena-Rodriguez, Amelia
IR  - Pena-Rodriguez A
FIR - Perez, Esther
IR  - Perez E
FIR - Poyato, Manuel
IR  - Poyato M
FIR - Praena-Segovia, Julia
IR  - Praena-Segovia J
FIR - Rios, Rafaela
IR  - Rios R
FIR - Roca-Oporto, Cristina
IR  - Roca-Oporto C
FIR - Rodriguez, Jesus F
IR  - Rodriguez JF
FIR - Rodriguez-Hernandez, Maria Jesus
IR  - Rodriguez-Hernandez MJ
FIR - Rodriguez-Suarez, Santiago
IR  - Rodriguez-Suarez S
FIR - Rodriguez-Villodres, Angel
IR  - Rodriguez-Villodres A
FIR - Romero-Rodriguez, Nieves
IR  - Romero-Rodriguez N
FIR - Ruiz, Ricardo
IR  - Ruiz R
FIR - de Azua, Zida Ruiz
IR  - de Azua ZR
FIR - Salamanca, Celia
IR  - Salamanca C
FIR - Sanchez, Sonia
IR  - Sanchez S
FIR - Sanchez-Montagut, Victor Manuel
IR  - Sanchez-Montagut VM
FIR - Sotomayor, Cesar
IR  - Sotomayor C
FIR - Benjumea, Alejandro Suarez
IR  - Benjumea AS
FIR - Toral, Javier
IR  - Toral J
EDAT- 2021/07/23 06:00
MHDA- 2021/09/22 06:00
PMCR- 2022/09/01
CRDT- 2021/07/22 06:25
PHST- 2021/04/13 00:00 [received]
PHST- 2021/06/17 00:00 [accepted]
PHST- 2021/07/23 06:00 [pubmed]
PHST- 2021/09/22 06:00 [medline]
PHST- 2021/07/22 06:25 [entrez]
PHST- 2022/09/01 00:00 [pmc-release]
AID - 10.1038/s41423-021-00728-2 [pii]
AID - 728 [pii]
AID - 10.1038/s41423-021-00728-2 [doi]
PST - ppublish
SO  - Cell Mol Immunol. 2021 Sep;18(9):2128-2139. doi: 10.1038/s41423-021-00728-2. Epub 
      2021 Jul 21.