PMID- 34290863
OWN - NLM
STAT- MEDLINE
DCOM- 20220105
LR  - 20220121
IS  - 2048-6790 (Electronic)
IS  - 2048-6790 (Linking)
VI  - 10
DP  - 2021
TI  - Postprandial effects of a whey protein-based multi-ingredient nutritional drink 
      compared with a normal breakfast on glucose, insulin, and active GLP-1 response 
      among type 2 diabetic subjects: a crossover randomised controlled trial.
PG  - e49
LID - 10.1017/jns.2021.41 [doi]
LID - e49
AB  - Postprandial hyperglycaemia is recognised as an important target in type 2 
      diabetes management. Dietary pattern, meal composition, and amount of food intake 
      are major factors for maintaining postprandial blood glucose levels. The aim of 
      this study was to investigate the effect of consuming a whey protein-based 
      multi-ingredient nutritional drink (WD) on postprandial glycaemic, insulinaemic, 
      and active glucagon-like peptide-1 (GLP-1) responses in comparison to a typical 
      breakfast, which is boiled white rice with chicken (BC) in patients with type 2 
      diabetes mellitus (T2DM). Fifteen subjects with T2DM participated in a 
      randomised, controlled, cross-over study. Two isocaloric diets with similar 
      nutrient composition were randomly tested with at least 7 d in between. Glucose, 
      insulin, and active GLP-1 were measured by standard methods with blood samples 
      collected with a venous catheter for 240 min during a kinetic test. The 
      incremental area under the curve (iAUC(0-240 min)) for plasma glucose was 
      significantly lower after the consumption of WD (WD: 3551 +/- 546; BC: 9610 +/- 848 
      mg min/dl; P < 0⋅01), while insulinaemic response tended to be lesser (iAUC(0-240 
      min)) than those of BC. In addition, higher iAUC(0-240 min) for active GLP-1 was 
      obtained with WD diet (WD: 2230 +/- 441; BC: 925 +/- 183 pM min/ml; P < 0⋅01). This 
      study showed that WD can be used to replace a regular breakfast for improving 
      postprandial glucose response and active GLP-1 levels in people with T2DM. 
      Further studies are required to elucidate the clinical efficacy of WD on 
      long-term glycaemic control in people with T2DM.
CI  - (c) The Author(s) 2021.
FAU - Sridonpai, Pimnapanut
AU  - Sridonpai P
AD  - Institute of Nutrition, Mahidol University, Nakhon Pathom, Thailand.
FAU - Prachansuwan, Aree
AU  - Prachansuwan A
AD  - Institute of Nutrition, Mahidol University, Nakhon Pathom, Thailand.
FAU - Praengam, Kemika
AU  - Praengam K
AD  - Institute of Nutrition, Mahidol University, Nakhon Pathom, Thailand.
FAU - Tuntipopipat, Siriporn
AU  - Tuntipopipat S
AD  - Institute of Nutrition, Mahidol University, Nakhon Pathom, Thailand.
FAU - Kriengsinyos, Wantanee
AU  - Kriengsinyos W
AD  - Institute of Nutrition, Mahidol University, Nakhon Pathom, Thailand.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20210712
PL  - England
TA  - J Nutr Sci
JT  - Journal of nutritional science
JID - 101590587
RN  - 0 (Blood Glucose)
RN  - 0 (Insulin)
RN  - 0 (Whey Proteins)
RN  - 89750-14-1 (Glucagon-Like Peptide 1)
SB  - IM
MH  - *Blood Glucose
MH  - Breakfast
MH  - Cross-Over Studies
MH  - *Diabetes Mellitus, Type 2
MH  - Glucagon-Like Peptide 1/*blood
MH  - Humans
MH  - *Insulin/blood
MH  - Postprandial Period
MH  - Whey Proteins/*administration & dosage
PMC - PMC8278161
OTO - NOTNLM
OT  - Acute glycaemic response
OT  - BC, boiled white rice with chicken
OT  - BMI, body mass index
OT  - Breakfast meal
OT  - GLP-1, glucagon-like peptide-1
OT  - Glucagon-like peptide-1
OT  - T2DM, type 2 diabetes mellitus
OT  - WD, whey protein-based multi-ingredient nutritional drink
OT  - Whey protein
OT  - Xylitol
OT  - iAUC, incremental area under the curve
OT  - min, minute
OT  - sem, standard error of the mean
EDAT- 2021/07/23 06:00
MHDA- 2022/01/06 06:00
PMCR- 2021/01/01
CRDT- 2021/07/22 06:34
PHST- 2021/02/24 00:00 [received]
PHST- 2021/06/10 00:00 [revised]
PHST- 2021/06/17 00:00 [accepted]
PHST- 2021/07/22 06:34 [entrez]
PHST- 2021/07/23 06:00 [pubmed]
PHST- 2022/01/06 06:00 [medline]
PHST- 2021/01/01 00:00 [pmc-release]
AID - S2048679021000410 [pii]
AID - 10.1017/jns.2021.41 [doi]
PST - epublish
SO  - J Nutr Sci. 2021 Jul 12;10:e49. doi: 10.1017/jns.2021.41. eCollection 2021.