PMID- 34291133
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210723
IS  - 2352-3042 (Electronic)
IS  - 2352-4820 (Print)
IS  - 2352-3042 (Linking)
VI  - 8
IP  - 5
DP  - 2021 Sep
TI  - Regeneration and activation of liver progenitor cells in liver cirrhosis.
PG  - 623-628
LID - 10.1016/j.gendis.2020.07.016 [doi]
AB  - Cirrhosis is characterized as the progress of regenerative nodules surrounded by 
      fibrous bands in response to chronic hepatic injury and causes portal 
      hypertension and end-stage hepatic disease. Following liver injury, liver 
      progenitor cells (LPCs) can be activated and differentiate into hepatocytes in 
      order to awaken liver regeneration and reach homeostasis. Recent research has 
      uncovered some new sources of LPCs. Here, we update the mechanisms of 
      LPCs-mediated liver regeneration in cirrhosis by introducing the origin of LPCs 
      and LPCs' niche with a discussion of the influence of LPC-related cells. This 
      article analyzes the mechanism of regeneration and activation of LPCs in 
      cirrhosis in recent years aiming to provide help for clinical application.
CI  - (c) 2020 Chongqing Medical University. Production and hosting by Elsevier B.V.
FAU - Yin, Yanze
AU  - Yin Y
AD  - Department of Liver Surgery, Renji Hospital, School of Medicine, Shanghai Jiao 
      Tong University, Shanghai, 200240, PR China.
FAU - Kong, Defu
AU  - Kong D
AD  - Department of Hepatology & Gastroenterology, University Medical Center Groningen, 
      Groningen, 9713, the Netherlands.
FAU - He, Kang
AU  - He K
AD  - Department of Liver Surgery, Renji Hospital, School of Medicine, Shanghai Jiao 
      Tong University, Shanghai, 200240, PR China.
FAU - Xia, Qiang
AU  - Xia Q
AD  - Department of Liver Surgery, Renji Hospital, School of Medicine, Shanghai Jiao 
      Tong University, Shanghai, 200240, PR China.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20200808
PL  - Netherlands
TA  - Genes Dis
JT  - Genes & diseases
JID - 101635967
PMC - PMC8278536
OTO - NOTNLM
OT  - Activation
OT  - Cytokines
OT  - Extracellular matrix
OT  - Hepatic stellate cells
OT  - Liver cirrhosis
OT  - Liver progenitor cells
OT  - Liver regeneration
OT  - Niche
EDAT- 2021/07/23 06:00
MHDA- 2021/07/23 06:01
PMCR- 2020/08/08
CRDT- 2021/07/22 06:37
PHST- 2020/04/08 00:00 [received]
PHST- 2020/06/20 00:00 [revised]
PHST- 2020/07/31 00:00 [accepted]
PHST- 2021/07/22 06:37 [entrez]
PHST- 2021/07/23 06:00 [pubmed]
PHST- 2021/07/23 06:01 [medline]
PHST- 2020/08/08 00:00 [pmc-release]
AID - S2352-3042(20)30099-4 [pii]
AID - 10.1016/j.gendis.2020.07.016 [doi]
PST - epublish
SO  - Genes Dis. 2020 Aug 8;8(5):623-628. doi: 10.1016/j.gendis.2020.07.016. 
      eCollection 2021 Sep.