PMID- 34291833
OWN - NLM
STAT- MEDLINE
DCOM- 20220506
LR  - 20220506
IS  - 1439-0396 (Electronic)
IS  - 0931-2439 (Linking)
VI  - 106
IP  - 3
DP  - 2022 May
TI  - Impacts of caffeine on resistant chicken's performance and cardiovascular gene 
      expression.
PG  - 566-574
LID - 10.1111/jpn.13608 [doi]
AB  - We previously reported a study on 288 broiler (Gallus gallus) chicks who received 
      caffeine in water between days 3 and 42, at levels of 0, 6.25, 12.5, 25, 50 and 
      100 mg/kg body weight (BW)/day. In the previous report, we found that caffeine 
      caused pulmonary hypertension (PH)-associated mortality in a significant minority 
      (20%-30%) of birds, including right ventricular hypertrophy and ascites. We have 
      also shown a significant upregulation of the serotonin transporter (SERT), 
      troponin T2, adenosine A(1) receptor (ADORA1) and phosphodiesterase 5A (PDE5) in 
      chicken suffering from PH. Here, we examine the resistant (survived) chicks from 
      the first study that had not died due to acute heart failure and did not have 
      clinical signs of pulmonary hypertension. Our goal was to determine whether birds 
      who lacked overt signs of disease had subclinical manifestations, including 
      similar changes in gene expression, growth rates and altered systemic 
      haemodynamics. We found that growth was significantly increased by caffeine 
      consumption (p < 0.01) at low doses; however, dosage over 50 mg/BW/d had 
      remarkable adverse effects on growth (p < 0.01). Blood pressure, troponin T2 and 
      PDE5 gene expression were not significantly altered by caffeine administration 
      (p > 0.05). However, SERT gene expression linearly increased with increasing 
      caffeine dosage (p < 0.01). The impact of caffeine on ADORA1 gene expression was 
      dose dependent and nonlinear. In conclusion, despite the significant effects of 
      caffeine on birds' growth, no significant negative effects of caffeine were 
      observed on the cardiovascular function of resistant chickens. This work provides 
      valuable information for further study on different dosage of caffeine in an 
      animal model.
CI  - (c) 2021 Wiley-VCH GmbH.
FAU - Kamely, Mohammad
AU  - Kamely M
AUID- ORCID: 0000-0003-0925-240X
AD  - Department of Poultry Science, Faculty of Agriculture, Tarbiat Modares 
      University, Tehran, Iran.
AD  - Division Animal and Human Health Engineering, Faculty of Bioscience Engineering, 
      University of KU Leuven, Leuven, Belgium.
FAU - Karimi Torshizi, Mohammad Amir
AU  - Karimi Torshizi MA
AD  - Department of Poultry Science, Faculty of Agriculture, Tarbiat Modares 
      University, Tehran, Iran.
FAU - West, James
AU  - West J
AD  - Division of Allergy, Pulmonary, and Critical Care Medicine, Department of 
      Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
FAU - Niewold, Theo
AU  - Niewold T
AD  - Niewold Consultancy, Bierbeek, Belgium.
LA  - eng
PT  - Journal Article
DEP - 20210722
PL  - Germany
TA  - J Anim Physiol Anim Nutr (Berl)
JT  - Journal of animal physiology and animal nutrition
JID - 101126979
RN  - 0 (Receptor, Adenosine A1)
RN  - 0 (Troponin T)
RN  - 3G6A5W338E (Caffeine)
SB  - IM
MH  - Animals
MH  - Caffeine/pharmacology
MH  - *Chickens/metabolism
MH  - Gene Expression
MH  - *Hypertension, Pulmonary/veterinary
MH  - Receptor, Adenosine A1/genetics/metabolism
MH  - Troponin T/genetics
OTO - NOTNLM
OT  - broiler
OT  - caffeine
OT  - gene expression
OT  - lactic acid dehydrogenase
OT  - phosphodiesterase
OT  - serotonin transporter
EDAT- 2021/07/23 06:00
MHDA- 2022/05/07 06:00
CRDT- 2021/07/22 08:47
PHST- 2021/06/16 00:00 [revised]
PHST- 2020/09/11 00:00 [received]
PHST- 2021/07/06 00:00 [accepted]
PHST- 2021/07/23 06:00 [pubmed]
PHST- 2022/05/07 06:00 [medline]
PHST- 2021/07/22 08:47 [entrez]
AID - 10.1111/jpn.13608 [doi]
PST - ppublish
SO  - J Anim Physiol Anim Nutr (Berl). 2022 May;106(3):566-574. doi: 10.1111/jpn.13608. 
      Epub 2021 Jul 22.