PMID- 34292117
OWN - NLM
STAT- MEDLINE
DCOM- 20220616
LR  - 20220616
IS  - 1365-2931 (Electronic)
IS  - 1364-5706 (Linking)
VI  - 31
IP  - 5
DP  - 2022 Jun
TI  - Needle-based confocal laser endomicroscopy for diagnosis of pancreatic cystic 
      lesions: a meta-analysis.
PG  - 653-663
LID - 10.1080/13645706.2021.1888750 [doi]
AB  - BACKGROUND AND AIM: The role of needle-based confocal laser endomicroscopy (nCLE) 
      in the diagnosis of pancreatic cystic lesions (PCLs) remains controversial. This 
      study aimed to systematically evaluate the diagnostic accuracy and adverse 
      effects of nCLE in the detection of pathological subtypes in patients with PCLs. 
      MATERIAL AND METHODS: We conducted a comprehensive literature search using 
      MEDLINE, EMBASE, and Cochrane for identifying studies that reported the use of 
      nCLE for PCLs diagnosis (dated prior to 10 October 2020). Studies with a sample 
      size >10 were included. We used the QUADAS-2 criteria for quality evaluation. We 
      first extracted the diagnostic rates and the information on adverse events (AEs) 
      from the studies; then used STATA15.0 to calculate the variables, draw forest 
      plots and summary receiver operating characteristic (SROC) curves; and finally, 
      we completed subgroup analyses to explore the heterogeneity. RESULTS: Overall, 
      299 article titles were identified after an initial search, and ten studies with 
      547 individuals with PCLs were included in the analysis. The pooled sensitivity, 
      specificity, positive likelihood ratio, and pooled negative likelihood ratio of 
      nCLE in detecting gastric disorders were 90%, 96%, 20.4, and 0.11, respectively. 
      The pooled sensitivity and specificity showed a substantial heterogeneity. An ROC 
      curve was constructed with an area under the curve (AUC) of 0.94. The overall AEs 
      rate of pancreatitis was 2.7%. CONCLUSIONS: We showed that nCLE had a relatively 
      high sensitivity and specificity for diagnosing PCLs with a relatively low rate 
      of AEs occurring. We suggest that nCLE has good diagnostic accuracy for PCLs.
FAU - Wang, Xinyue
AU  - Wang X
AD  - Department of Gastroenterology, Shengjing Hospital of China Medical University, 
      Shenyang, China.
FAU - Hu, Jinlong
AU  - Hu J
AD  - Department of Gastroenterology, Shengjing Hospital of China Medical University, 
      Shenyang, China.
FAU - Yang, Fei
AU  - Yang F
AD  - Department of Gastroenterology, Shengjing Hospital of China Medical University, 
      Shenyang, China.
FAU - Yang, Fan
AU  - Yang F
AD  - Department of Gastroenterology, Shengjing Hospital of China Medical University, 
      Shenyang, China.
FAU - Sun, Siyu
AU  - Sun S
AD  - Department of Gastroenterology, Shengjing Hospital of China Medical University, 
      Shenyang, China.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
DEP - 20210722
PL  - England
TA  - Minim Invasive Ther Allied Technol
JT  - Minimally invasive therapy & allied technologies : MITAT : official journal of 
      the Society for Minimally Invasive Therapy
JID - 9612996
SB  - IM
MH  - Endoscopic Ultrasound-Guided Fine Needle Aspiration
MH  - Humans
MH  - Lasers
MH  - Microscopy, Confocal
MH  - *Pancreatic Cyst/diagnosis/pathology
MH  - *Pancreatic Neoplasms/diagnosis/pathology
OTO - NOTNLM
OT  - Microscopy
OT  - adverse effect
OT  - confocal
OT  - diagnosis
OT  - endosonography
OT  - pancreatic cyst
EDAT- 2021/07/23 06:00
MHDA- 2022/06/18 06:00
CRDT- 2021/07/22 12:19
PHST- 2021/07/23 06:00 [pubmed]
PHST- 2022/06/18 06:00 [medline]
PHST- 2021/07/22 12:19 [entrez]
AID - 10.1080/13645706.2021.1888750 [doi]
PST - ppublish
SO  - Minim Invasive Ther Allied Technol. 2022 Jun;31(5):653-663. doi: 
      10.1080/13645706.2021.1888750. Epub 2021 Jul 22.