PMID- 34292389
OWN - NLM
STAT- MEDLINE
DCOM- 20220406
LR  - 20220406
IS  - 1615-2573 (Electronic)
IS  - 0910-8327 (Print)
IS  - 0910-8327 (Linking)
VI  - 37
IP  - 2
DP  - 2022 Feb
TI  - The clinical and prognostic value of late Gadolinium enhancement imaging in heart 
      failure with mid-range and preserved ejection fraction.
PG  - 273-281
LID - 10.1007/s00380-021-01910-2 [doi]
AB  - Heart failure (HF) with mid-range or preserved ejection fraction (HFmrEF; HFpEF) 
      is a heterogeneous disorder that could benefit from strategies to identify 
      subpopulations at increased risk. We tested the hypothesis that HFmrEF and HFpEF 
      patients with myocardial scars detected with late gadolinium enhancement (LGE) 
      are at increased risk for all-cause mortality. Symptomatic HF patients with left 
      ventricular ejection fraction (LVEF) > 40%, who underwent cardiac magnetic 
      resonance (CMR) imaging were included. The presence of myocardial LGE lesions was 
      visually assessed. T1 mapping was performed to calculate extracellular volume 
      (ECV). Multivariable logistic regression analyses were used to determine 
      associations between clinical characteristics and LGE. Cox regression analyses 
      were used to assess the association between LGE and all-cause mortality. A total 
      of 110 consecutive patients were included (mean age 71 +/- 10 years, 49% women, 
      median N-terminal brain natriuretic peptide (NT-proBNP) 1259 pg/ml). LGE lesions 
      were detected in 37 (34%) patients. Previous myocardial infarction and increased 
      LV mass index were strong and independent predictors for the presence of LGE 
      (odds ratio 6.32, 95% confidence interval (CI) 2.07-19.31, p = 0.001 and 1.68 
      (1.03-2.73), p = 0.04, respectively). ECV was increased in patients with LGE 
      lesions compared to those without (28.6 vs. 26.6%, p = 0.04). The presence of LGE 
      lesions was associated with a fivefold increase in the incidence of all-cause 
      mortality (hazards ratio 5.3, CI 1.5-18.1, p = 0.009), independent of age, sex, 
      New York Heart Association (NYHA) functional class, NT-proBNP, LGE mass and LVEF. 
      Myocardial scarring on CMR is associated with increased mortality in HF patients 
      with LVEF > 40% and may aid in selecting a subpopulation at increased risk.
CI  - (c) 2021. The Author(s).
FAU - van Woerden, Gijs
AU  - van Woerden G
AUID- ORCID: 0000-0001-7907-2944
AD  - Department of Cardiology, University of Groningen, University Medical Centre 
      Groningen, Hanzeplein 1, PO Box 30.001, 9700 RB, Groningen, The Netherlands.
FAU - van Veldhuisen, Dirk J
AU  - van Veldhuisen DJ
AD  - Department of Cardiology, University of Groningen, University Medical Centre 
      Groningen, Hanzeplein 1, PO Box 30.001, 9700 RB, Groningen, The Netherlands.
FAU - Gorter, Thomas M
AU  - Gorter TM
AD  - Department of Cardiology, University of Groningen, University Medical Centre 
      Groningen, Hanzeplein 1, PO Box 30.001, 9700 RB, Groningen, The Netherlands.
FAU - Willems, Tineke P
AU  - Willems TP
AD  - Department of Radiology, University of Groningen, University Medical Centre 
      Groningen, Groningen, The Netherlands.
FAU - van Empel, Vanessa P M
AU  - van Empel VPM
AD  - Department of Cardiology, University of Maastricht, Medical University Centre 
      Maastricht, Maastricht, The Netherlands.
FAU - Peters, Aniek
AU  - Peters A
AD  - Department of Cardiology, University of Groningen, University Medical Centre 
      Groningen, Hanzeplein 1, PO Box 30.001, 9700 RB, Groningen, The Netherlands.
FAU - Pundziute, Gabija
AU  - Pundziute G
AD  - Department of Cardiology, University of Groningen, University Medical Centre 
      Groningen, Hanzeplein 1, PO Box 30.001, 9700 RB, Groningen, The Netherlands.
FAU - Op den Akker, Jeroen W
AU  - Op den Akker JW
AD  - Department of Radiology, University of Groningen, University Medical Centre 
      Groningen, Groningen, The Netherlands.
FAU - Rienstra, Michiel
AU  - Rienstra M
AD  - Department of Cardiology, University of Groningen, University Medical Centre 
      Groningen, Hanzeplein 1, PO Box 30.001, 9700 RB, Groningen, The Netherlands.
FAU - Westenbrink, B Daan
AU  - Westenbrink BD
AD  - Department of Cardiology, University of Groningen, University Medical Centre 
      Groningen, Hanzeplein 1, PO Box 30.001, 9700 RB, Groningen, The Netherlands. 
      b.d.westenbrink@umcg.nl.
LA  - eng
PT  - Journal Article
DEP - 20210722
PL  - Japan
TA  - Heart Vessels
JT  - Heart and vessels
JID - 8511258
RN  - 0 (Contrast Media)
RN  - AU0V1LM3JT (Gadolinium)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Contrast Media
MH  - Female
MH  - *Gadolinium
MH  - *Heart Failure
MH  - Humans
MH  - Magnetic Resonance Imaging, Cine
MH  - Male
MH  - Middle Aged
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - Stroke Volume
MH  - Ventricular Function, Left
PMC - PMC8794962
OTO - NOTNLM
OT  - Cardiac magnetic resonance imaging
OT  - HFmrEF
OT  - HFpEF
OT  - Mortality
OT  - Myocardial scar
COIS- None.
EDAT- 2021/07/23 06:00
MHDA- 2022/04/07 06:00
PMCR- 2021/07/22
CRDT- 2021/07/22 12:28
PHST- 2021/03/25 00:00 [received]
PHST- 2021/07/16 00:00 [accepted]
PHST- 2021/07/23 06:00 [pubmed]
PHST- 2022/04/07 06:00 [medline]
PHST- 2021/07/22 12:28 [entrez]
PHST- 2021/07/22 00:00 [pmc-release]
AID - 10.1007/s00380-021-01910-2 [pii]
AID - 1910 [pii]
AID - 10.1007/s00380-021-01910-2 [doi]
PST - ppublish
SO  - Heart Vessels. 2022 Feb;37(2):273-281. doi: 10.1007/s00380-021-01910-2. Epub 2021 
      Jul 22.