PMID- 34292661
OWN - NLM
STAT- MEDLINE
DCOM- 20211105
LR  - 20211105
IS  - 1612-1880 (Electronic)
IS  - 1612-1872 (Linking)
VI  - 18
IP  - 9
DP  - 2021 Sep
TI  - Neo-clerodane Diterpenoids with Hypoglycemic Effects in Vivo from the Aerial 
      Parts of Salvia hispanica L.
PG  - e2100517
LID - 10.1002/cbdv.202100517 [doi]
AB  - A new neo-clerodane diterpenoid, salvihispin H (1), and six known ones (2-7) were 
      identified from the aerial parts of Salvia hispanica L. The structure and 
      absolute configuration of 1 were elucidated by extensive analysis of 
      spectroscopic ((1) H, (13) C, and 2D NMR, and HR-ESI-MS) and single-crystal X-ray 
      diffraction data. The anti-diabetic effects of salvihispin H (1) and salvifaricin 
      (2) were evaluated in diabetic db/db mice. The data showed that 1 and 2 could 
      significantly reduce fasting blood glucose level and improve insulin resistance, 
      and compound 1 exerted glucose-lowering effect more quickly than metformin. In 
      addition, 1 and 2 could also reduce serum TG level in db/db mice. These results 
      demonstrated that compounds 1 and 2 could be considered as potent candidates for 
      the therapy of type 2 diabetes mellitus (T2DM).
CI  - (c) 2021 Wiley-VHCA AG, Zurich, Switzerland.
FAU - Fan, Min
AU  - Fan M
AD  - State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming 
      Institute of Botany, Chinese Academy of Sciences, Kunming, 650204, P. R. China.
AD  - College of Pharmacy, Dali University, Dali, 671000, P. R. China.
FAU - Wang, Ting
AU  - Wang T
AD  - Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 
      201203, P. R. China.
FAU - Peng, Li-Yan
AU  - Peng LY
AD  - State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming 
      Institute of Botany, Chinese Academy of Sciences, Kunming, 650204, P. R. China.
FAU - Huang, Jun-Shang
AU  - Huang JS
AD  - Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 
      201203, P. R. China.
FAU - Wu, Xing-De
AU  - Wu XD
AD  - State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming 
      Institute of Botany, Chinese Academy of Sciences, Kunming, 650204, P. R. China.
FAU - Wang, He-Yao
AU  - Wang HY
AD  - Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 
      201203, P. R. China.
FAU - Zhao, Qin-Shi
AU  - Zhao QS
AUID- ORCID: 0000-0002-1249-2917
AD  - State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming 
      Institute of Botany, Chinese Academy of Sciences, Kunming, 650204, P. R. China.
LA  - eng
GR  - P2018-KF04/State Key Laboratory of Phytochemistry and Plant Resources in West 
      China/
GR  - 21837003/National Natural Science Foundation of China/
GR  - 81773611/National Natural Science Foundation of China/
GR  - 2018ZF001/Science and Technology Program of Yunnan province/
GR  - 2019FA037/Science and Technology Program of Yunnan province/
GR  - Top Young Talent of the Ten Thousand Talents Program of Yunnan Province/
PT  - Journal Article
DEP - 20210804
PL  - Switzerland
TA  - Chem Biodivers
JT  - Chemistry & biodiversity
JID - 101197449
RN  - 0 (Blood Glucose)
RN  - 0 (Diterpenes, Clerodane)
RN  - 0 (Hypoglycemic Agents)
SB  - IM
MH  - Animals
MH  - Blood Glucose/drug effects
MH  - Crystallography, X-Ray
MH  - Diabetes Mellitus, Experimental/*drug therapy/metabolism
MH  - Diabetes Mellitus, Type 2/*drug therapy/metabolism
MH  - Disease Models, Animal
MH  - Diterpenes, Clerodane/chemistry/*pharmacology
MH  - Hypoglycemic Agents/chemistry/*pharmacology
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Models, Molecular
MH  - Molecular Structure
MH  - Plant Components, Aerial/*chemistry
MH  - Salvia/*chemistry
OTO - NOTNLM
OT  - Salvia hispanica
OT  - neo-clerodane diterpenoid
OT  - salvihispin H
OT  - type 2 diabetes mellitus
EDAT- 2021/07/23 06:00
MHDA- 2021/11/06 06:00
CRDT- 2021/07/22 12:41
PHST- 2021/06/30 00:00 [received]
PHST- 2021/07/22 00:00 [accepted]
PHST- 2021/07/23 06:00 [pubmed]
PHST- 2021/11/06 06:00 [medline]
PHST- 2021/07/22 12:41 [entrez]
AID - 10.1002/cbdv.202100517 [doi]
PST - ppublish
SO  - Chem Biodivers. 2021 Sep;18(9):e2100517. doi: 10.1002/cbdv.202100517. Epub 2021 
      Aug 4.