PMID- 34292764
OWN - NLM
STAT- MEDLINE
DCOM- 20210726
LR  - 20210807
IS  - 1473-2300 (Electronic)
IS  - 0300-0605 (Print)
IS  - 0300-0605 (Linking)
VI  - 49
IP  - 7
DP  - 2021 Jul
TI  - Analysis of the association and predictive value of hyperhomocysteinaemia for 
      obstructive coronary artery disease.
PG  - 3000605211033495
LID - 10.1177/03000605211033495 [doi]
LID - 03000605211033495
AB  - OBJECTIVE: To investigate the predictive value of hyperhomocysteinaemia (HHcy) 
      for obstructive coronary artery disease (CAD) in an Asian population in northern 
      China. METHODS: This retrospective study enrolled patients at their first cardiac 
      assessment and assigned them to an obstructive CAD group or a non-obstructive CAD 
      group according to the coronary angiography results. HHcy was defined as a 
      homocysteine (Hcy) level > 15 micromol/l. RESULTS: This study enrolled 2987 
      participants: 1172 in the non-obstructive CAD group and 1815 in the obstructive 
      CAD group. Hcy level in the obstructive CAD group was significantly higher than 
      in the non-obstructive CAD group. The proportion of patients with HHcy in the 
      obstructive CAD group was significantly greater than in the non-obstructive CAD 
      group. Multivariate logistic regression analysis demonstrated that HHcy was 
      independently correlated with obstructive CAD in both young (aged </= 55 years) and 
      old patients (aged > 55 years). HHcy showed a higher sensitivity (93.1%), 
      specificity (86.1%) and accuracy (90.0%) for obstructive CAD. The odds ratio for 
      HHcy was 84.2. The Kappa value (0.8) showed substantial agreement between 
      obstructive CAD and HHcy. CONCLUSIONS: HHcy was associated with obstructive CAD 
      and may be a potentially independent risk factor for obstructive CAD with good 
      predictive value.
FAU - Wu, Hao-Yu
AU  - Wu HY
AD  - Department of Cardiology, Shaanxi Provincial People's Hospital, Xi'an, Shaanxi 
      Province, China.
FAU - Gao, Tian-Jiao
AU  - Gao TJ
AD  - Department of Gastroenterology, Xi'an Children's Hospital, Xi'an, Shaanxi 
      Province, China.
FAU - Cao, Yi-Wei
AU  - Cao YW
AUID- ORCID: 0000-0002-3195-5489
AD  - Department of Electrocardiology, Shaanxi Provincial People's Hospital, Xi'an, 
      Shaanxi Province, China.
FAU - Diao, Jia-Yu
AU  - Diao JY
AD  - Department of Cardiology, Shaanxi Provincial People's Hospital, Xi'an, Shaanxi 
      Province, China.
FAU - You, Peng-Hua
AU  - You PH
AD  - Department of Cardiology, Shaanxi Provincial People's Hospital, Xi'an, Shaanxi 
      Province, China.
FAU - Yao, Xiao-Wei
AU  - Yao XW
AD  - Department of Cardiology, Shaanxi Provincial People's Hospital, Xi'an, Shaanxi 
      Province, China.
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Int Med Res
JT  - The Journal of international medical research
JID - 0346411
RN  - 0LVT1QZ0BA (Homocysteine)
SB  - IM
MH  - China
MH  - Coronary Angiography
MH  - *Coronary Artery Disease/diagnostic imaging
MH  - Homocysteine
MH  - Humans
MH  - *Hyperhomocysteinemia/complications/diagnosis
MH  - Retrospective Studies
MH  - Risk Factors
PMC - PMC8312177
OTO - NOTNLM
OT  - Coronary artery disease
OT  - homocysteine
OT  - hyperhomocysteinaemia
OT  - northern China
OT  - risk prediction
COIS- Declaration of conflicting interest: The authors declare that there are no 
      conflicts of interest.
EDAT- 2021/07/23 06:00
MHDA- 2021/07/27 06:00
PMCR- 2021/07/22
CRDT- 2021/07/22 17:15
PHST- 2021/07/22 17:15 [entrez]
PHST- 2021/07/23 06:00 [pubmed]
PHST- 2021/07/27 06:00 [medline]
PHST- 2021/07/22 00:00 [pmc-release]
AID - 10.1177_03000605211033495 [pii]
AID - 10.1177/03000605211033495 [doi]
PST - ppublish
SO  - J Int Med Res. 2021 Jul;49(7):3000605211033495. doi: 10.1177/03000605211033495.