PMID- 34293861
OWN - NLM
STAT- MEDLINE
DCOM- 20210826
LR  - 20210826
IS  - 1520-5118 (Electronic)
IS  - 0021-8561 (Linking)
VI  - 69
IP  - 33
DP  - 2021 Aug 25
TI  - Bioconcentration and Metabolism of the New Herbicide Methiozolin in Ricefish 
      (Oryzias latipes).
PG  - 9536-9544
LID - 10.1021/acs.jafc.1c02621 [doi]
AB  - Methiozolin is a novel herbicide used to control annual bluegrass. It has low 
      vapor pressure and high hydrophobicity, which could result in persistence in 
      water and bioaccumulation. We measured the bioconcentration factors (BCFs) of 
      methiozolin in ricefish (Oryzias latipes). Two radiolabels were used to quantify 
      the parent compound and identify its metabolites. Ricefish were exposed to 2.0 
      and 20.0 ng/L methiozolin for 28 days in the uptake phase with a 96-h LC(50) of 
      2.2 mg/L(95% confidence limit: 2.1-2.5 mg/L) and water solubility of 4.2 mg/L 
      after 48 h was observed. On the basis of total radioactivity residues (TRRs), 
      BCF(ss) and BCF(k) values of 797.0-851.9 and 992.9-1077.4 were observed, 
      respectively, while BCF(ss) values for methiozolin were 251.9-257.5. Several 
      minor metabolites with TRR < 3.4% were detected. Among them, 
      4-(2,6-difluorobenzyloxy-methyl)-3-hydroxy-3-methyl-1-(3-methylthiophen-2-yl)butan-1-one, 
      2,6-difluorobenzyl alcohol, and 
      4,5-dihydro-5-methyl-3-(3-methylthiophen-2-yl)isoxazol-5-yl)methanol were 
      identified. Methiozolin is metabolized into numerous minor metabolites with 
      potentially low bioaccumulation capacity in ricefish. These findings can 
      facilitate risk assessments regarding methiozolin use, particularly its movements 
      and final stages in aquatic environments.
FAU - Kim, Jong-Hwan
AU  - Kim JH
AD  - Environmental Chemistry Research Group, Korea Institute of Toxicology (KIT), 
      Jinju 52834, Republic of Korea.
FAU - Jeong, Seong-Hoon
AU  - Jeong SH
AD  - Environmental Chemistry Research Group, Korea Institute of Toxicology (KIT), 
      Jinju 52834, Republic of Korea.
FAU - Kim, Soo-Yeon
AU  - Kim SY
AD  - Environmental Chemistry Research Group, Korea Institute of Toxicology (KIT), 
      Jinju 52834, Republic of Korea.
FAU - Kwon, Young-Sang
AU  - Kwon YS
AD  - Environmental Chemistry Research Group, Korea Institute of Toxicology (KIT), 
      Jinju 52834, Republic of Korea.
FAU - Hwang, Ki-Hwan
AU  - Hwang KH
AD  - Moghu Research Center Ltd, B-228, Gajeong-ro 99, Yuseong, Daejeon 34115, Republic 
      of Korea.
FAU - Lim, Jong-Soo
AU  - Lim JS
AD  - Moghu Research Center Ltd, B-228, Gajeong-ro 99, Yuseong, Daejeon 34115, Republic 
      of Korea.
FAU - Seo, Jong-Su
AU  - Seo JS
AUID- ORCID: 0000-0003-1595-1338
AD  - Environmental Chemistry Research Group, Korea Institute of Toxicology (KIT), 
      Jinju 52834, Republic of Korea.
LA  - eng
PT  - Journal Article
DEP - 20210723
PL  - United States
TA  - J Agric Food Chem
JT  - Journal of agricultural and food chemistry
JID - 0374755
RN  - 0 (Herbicides)
RN  - 0 (Isoxazoles)
RN  - 0 (Thiophenes)
RN  - 0 (Water Pollutants, Chemical)
RN  - MK1KZ980DK (methiozolin)
SB  - IM
MH  - Animals
MH  - Bioaccumulation
MH  - *Herbicides
MH  - Isoxazoles
MH  - *Oryzias
MH  - Thiophenes
MH  - *Water Pollutants, Chemical
OTO - NOTNLM
OT  - Herbicide methiozolin
OT  - acute toxicity
OT  - bioconcentration factors
OT  - environmental pollution
OT  - flow-through exposure system
OT  - metabolites in fish
EDAT- 2021/07/24 06:00
MHDA- 2021/08/27 06:00
CRDT- 2021/07/23 05:27
PHST- 2021/07/24 06:00 [pubmed]
PHST- 2021/08/27 06:00 [medline]
PHST- 2021/07/23 05:27 [entrez]
AID - 10.1021/acs.jafc.1c02621 [doi]
PST - ppublish
SO  - J Agric Food Chem. 2021 Aug 25;69(33):9536-9544. doi: 10.1021/acs.jafc.1c02621. 
      Epub 2021 Jul 23.