PMID- 34294015
OWN - NLM
STAT- MEDLINE
DCOM- 20230425
LR  - 20230425
IS  - 2327-9109 (Electronic)
IS  - 2327-9095 (Linking)
VI  - 30
IP  - 4
DP  - 2023 Jul-Aug
TI  - Behavioral variations among vascular cognitive impairment subtypes - A 
      comparative study.
PG  - 439-446
LID - 10.1080/23279095.2021.1954002 [doi]
AB  - Dementia of vascular origin is a distinct variety with a heterogeneous 
      neuropsychological profile. Very few studies have compared the behavioral 
      dysfunction in the large vessel and small vessel vascular dementia (VaD) and 
      studied the association between executive dysfunction and behavioral dysfunction 
      documented in these patients, between the white matter load in small vessel 
      disease (SVD) and the behavioral dysfunction. 76 patients having a modified 
      Hachinski Ischemic Scale score of >/= 4 were recruited and categorized into a small 
      vessel and large vessel VaD. The Neuropsychiatric Inventory (NPI) score >/= 4 per 
      domain for defining clinically relevant symptoms and the Clinical Dementia Rating 
      Scale (CDR) for evaluating the severity of dementia were used. Behavioral and 
      Psychological Symptoms of Dementia (BPSD) were present in 66.67% of patients with 
      SVD and 53.57% of those having large vessel disease. Apathy, euphoria, and 
      disinhibition were more common in SVD, while appetite alterations were more 
      common in large vessel disease. Behavioral dysfunction was also associated with 
      executive dysfunction in both the VaD subtypes and with white matter loads in 
      SVD. We conclude that different VaD subtypes have different behavioral profiles. 
      This might help in understanding the underlying pathophysiology, diagnosis and 
      thus better management of this disorder.
FAU - Bhat, Ashwani
AU  - Bhat A
AUID- ORCID: 0000-0001-7577-9627
AD  - Department of Neurology, Institute of Postgraduate Medical Education and Research 
      Bangur Institute of Neurology, Kolkata, India.
FAU - Biswas, Atanu
AU  - Biswas A
AD  - Department of Neurology, Institute of Postgraduate Medical Education and Research 
      Bangur Institute of Neurology, Kolkata, India.
FAU - Das, Gautam
AU  - Das G
AD  - Department of Neurology, Institute of Postgraduate Medical Education and Research 
      Bangur Institute of Neurology, Kolkata, India.
FAU - Lahiri, Durjoy
AU  - Lahiri D
AD  - Department of Neurology, Institute of Postgraduate Medical Education and Research 
      Bangur Institute of Neurology, Kolkata, India.
FAU - Dubey, Souvik
AU  - Dubey S
AD  - Department of Neurology, Institute of Postgraduate Medical Education and Research 
      Bangur Institute of Neurology, Kolkata, India.
FAU - Mukherjee, Adreesh
AU  - Mukherjee A
AD  - Department of Neurology, Institute of Postgraduate Medical Education and Research 
      Bangur Institute of Neurology, Kolkata, India.
LA  - eng
PT  - Journal Article
DEP - 20210722
PL  - United States
TA  - Appl Neuropsychol Adult
JT  - Applied neuropsychology. Adult
JID - 101584082
SB  - IM
MH  - Humans
MH  - *Alzheimer Disease/complications
MH  - Neuropsychological Tests
MH  - *Dementia, Vascular/complications/diagnosis
MH  - *Cognitive Dysfunction/diagnosis/complications
MH  - *Apathy
OTO - NOTNLM
OT  - Behavioral neuropsychology
OT  - cognition
OT  - comparative
OT  - geriatric
EDAT- 2021/07/24 06:00
MHDA- 2023/04/25 06:42
CRDT- 2021/07/23 05:32
PHST- 2023/04/25 06:42 [medline]
PHST- 2021/07/24 06:00 [pubmed]
PHST- 2021/07/23 05:32 [entrez]
AID - 10.1080/23279095.2021.1954002 [doi]
PST - ppublish
SO  - Appl Neuropsychol Adult. 2023 Jul-Aug;30(4):439-446. doi: 
      10.1080/23279095.2021.1954002. Epub 2021 Jul 22.