PMID- 34294087
OWN - NLM
STAT- MEDLINE
DCOM- 20211230
LR  - 20211230
IS  - 1746-1596 (Electronic)
IS  - 1746-1596 (Linking)
VI  - 16
IP  - 1
DP  - 2021 Jul 22
TI  - Evaluation of prognostic histological parameters proposed for pleural 
      mesothelioma in diffuse malignant peritoneal mesothelioma. A short report.
PG  - 64
LID - 10.1186/s13000-021-01125-z [doi]
LID - 64
AB  - INTRODUCTION: Diffuse malignant peritoneal mesothelioma (DMPM) is a rare 
      malignant neoplasm with poor survival that shares some similarities with the 
      best-known pleural variant, pleural mesothelioma. The recent European Reference 
      Network on Rare Adult Cancers (EURACAN)/International Association for the Study 
      of Lung Cancer (IASLC) proposals attempted to improve the histological diagnosis 
      and patient risk stratification. Herein, we investigated whether the pathology 
      recommendations and suggestions of the pleural proposals were applicable to 
      diffuse malignant peritoneal mesothelioma. METHODS: Fifty multiple laparoscopic 
      biopsies of DMPM were consecutively collected at the Pathology Unit of the 
      University of Bari. A two-tier system, i.e., low, and high grade, was used to 
      categorize 34 epithelioid DMPMs. Architectural patterns, cytological features and 
      stromal changes were also reported. Immunohistochemistry was performed for 
      BRCA1-associated protein 1 (BAP1), programmed death-ligand 1 (PD-L1), and Ki67, 
      while fluorescence in situ hybridization (FISH) was performed for 
      p16/cyclin-dependent kinase inhibitor 2A (CDKN2A). RESULTS: High-grade 
      epithelioid mesothelioma, high Ki67, and p16/CDKN2A deletion were significantly 
      associated with short survival (p = 0.004, p < 0.0001, and p = 0.002, 
      respectively). BAP1 loss and PD-L1 negativity were the most common findings. 
      Multivariate analysis revealed that the nuclear grading system and p16 deletion 
      significantly correlated with survival (p = 0.003 each). CONCLUSIONS: The present 
      study examined the prognostic significance of several factors proposed for 
      pleural mesothelioma in an extra pleural site. Notably, the introduction of a 
      grading system may provide better risk stratification in epithelioid DMPM. Ki67, 
      BAP1 and p16/CDKN2A should also be measured whenever possible. A detailed report 
      with all supportive data would allow us to collect sufficient information for use 
      in further studies on larger case series.
CI  - (c) 2021. The Author(s).
FAU - Pezzuto, Federica
AU  - Pezzuto F
AUID- ORCID: 0000-0002-8023-3108
AD  - Pathology Unit Department of Cardiac, Thoracic, Vascular Sciences and Public 
      Health, University of Padova, via A. Gabelli 61, 35121, Padova, Italy. 
      federica.pezzuto@unipd.it.
FAU - Vimercati, Luigi
AU  - Vimercati L
AD  - Department of Interdisciplinary Medicine, Occupational Health Division, 
      University of Bari, 1 Umberto I Sq., 70121, Bari, Italy.
FAU - Fortarezza, Francesco
AU  - Fortarezza F
AD  - Pathology Unit Department of Cardiac, Thoracic, Vascular Sciences and Public 
      Health, University of Padova, via A. Gabelli 61, 35121, Padova, Italy.
FAU - Marzullo, Andrea
AU  - Marzullo A
AD  - Pathology Unit, Department of Emergency and Organ Transplantation - DETO, 
      University of Bari, 1 Umberto I Sq., 70121, Bari, Italy.
FAU - Pennella, Antonio
AU  - Pennella A
AD  - Pathology Unit, Department of Surgery, University of Foggia, 121 Napoli St, 
      71122, Foggia, Italy.
FAU - Cavone, Domenica
AU  - Cavone D
AD  - Department of Interdisciplinary Medicine, Occupational Health Division, 
      University of Bari, 1 Umberto I Sq., 70121, Bari, Italy.
FAU - Punzi, Alessandra
AU  - Punzi A
AD  - Pathology Unit, IRCCS National Cancer Institute "Giovanni Paolo II", 65 Orazio 
      Flacco St, 70124, Bari, Italy.
FAU - Caporusso, Concetta
AU  - Caporusso C
AD  - Pathology Unit, Department of Emergency and Organ Transplantation - DETO, 
      University of Bari, 1 Umberto I Sq., 70121, Bari, Italy.
FAU - d'Amati, Antonio
AU  - d'Amati A
AD  - Pathology Unit, Department of Emergency and Organ Transplantation - DETO, 
      University of Bari, 1 Umberto I Sq., 70121, Bari, Italy.
FAU - Lettini, Teresa
AU  - Lettini T
AD  - Pathology Unit, Department of Emergency and Organ Transplantation - DETO, 
      University of Bari, 1 Umberto I Sq., 70121, Bari, Italy.
FAU - Serio, Gabriella
AU  - Serio G
AD  - Pathology Unit, Department of Emergency and Organ Transplantation - DETO, 
      University of Bari, 1 Umberto I Sq., 70121, Bari, Italy.
LA  - eng
PT  - Journal Article
DEP - 20210722
PL  - England
TA  - Diagn Pathol
JT  - Diagnostic pathology
JID - 101251558
RN  - 0 (B7-H1 Antigen)
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (CD274 protein, human)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - B7-H1 Antigen/metabolism
MH  - Biomarkers, Tumor/analysis
MH  - Humans
MH  - Lung Neoplasms/diagnosis/*pathology
MH  - Mesothelioma/diagnosis/*pathology
MH  - Mesothelioma, Malignant/diagnosis/pathology
MH  - Middle Aged
MH  - Peritoneal Neoplasms/diagnosis/*pathology
MH  - Pleural Neoplasms/diagnosis/*pathology
MH  - Prognosis
PMC - PMC8296535
OTO - NOTNLM
OT  - Grading
OT  - Histology
OT  - Peritoneal mesothelioma
OT  - Pleural mesothelioma
COIS- The authors declare no competing interests.
EDAT- 2021/07/24 06:00
MHDA- 2021/12/31 06:00
PMCR- 2021/07/22
CRDT- 2021/07/23 05:35
PHST- 2020/10/29 00:00 [received]
PHST- 2021/07/06 00:00 [accepted]
PHST- 2021/07/23 05:35 [entrez]
PHST- 2021/07/24 06:00 [pubmed]
PHST- 2021/12/31 06:00 [medline]
PHST- 2021/07/22 00:00 [pmc-release]
AID - 10.1186/s13000-021-01125-z [pii]
AID - 1125 [pii]
AID - 10.1186/s13000-021-01125-z [doi]
PST - epublish
SO  - Diagn Pathol. 2021 Jul 22;16(1):64. doi: 10.1186/s13000-021-01125-z.