PMID- 34295789
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211112
IS  - 2224-4344 (Print)
IS  - 2224-4344 (Electronic)
IS  - 2224-4336 (Linking)
VI  - 10
IP  - 6
DP  - 2021 Jun
TI  - Ibuprofen induced Stevens-Johnson syndrome and liver injury in children: a case 
      report.
PG  - 1737-1742
LID - 10.21037/tp-21-8 [doi]
AB  - Stevens-Johnson syndrome (SJS) is a disorder that causes severe damage to the 
      skin and mucous membranes with bullous and erosive properties. Drug-induced liver 
      injury (DILI) is closely related to non-steroidal anti-inflammatory drugs (such 
      as ibuprofen). Liver injury caused by ibuprofen is often related to overdose, and 
      liver injury caused by normal dose is rare, and there are individual differences 
      in different situations. In this case, a child developed SJS and acute liver 
      injury after treatment with ibuprofen suspension. We described the 
      characteristics of related adverse reactions induced by ibuprofen, and analyzed 
      the relationship between SJS caused by the drug and related drug genes. 
      Glucocorticoids and antihistamines were used to treat dermatitis, reduced 
      glutathione (GSH) to protect the liver and plasma exchange detoxification. 
      Finally, the patient's dermatitis healed and the liver injury was significantly 
      improved. Many studies have suggested that DILI may be related to human leukocyte 
      antigen (HLA) genotyping. The detection of drug-related genes revealed that the 
      SJS and liver damage caused by ibuprofen might have been related to the positive 
      HLA-B*5801. This article suggests that attention should be paid to checking liver 
      function indicators after taking ibuprofen, and genetic screening can be used to 
      reduce the risk of gene-related adverse reactions when necessary.
CI  - 2021 Translational Pediatrics. All rights reserved.
FAU - Gui, Ming-Zhu
AU  - Gui MZ
AD  - Department of Pharmacy, Shanghai Children's Hospital, Shanghai Jiao Tong 
      University, Shanghai, China.
AD  - Department of Pediatrics, Luodian Hospital, Shanghai, China.
FAU - Ni, Ming
AU  - Ni M
AD  - Department of Pediatrics, Luodian Hospital, Shanghai, China.
AD  - Department of Clinical Pharmacy, Shaoxing Maternity and Child Health Care 
      Hospital, Shaoxing, China.
FAU - Yin, Xue-Dong
AU  - Yin XD
AD  - Department of Pediatrics, Luodian Hospital, Shanghai, China.
FAU - Zhang, Ting
AU  - Zhang T
AD  - Department of Gastroenterology, Shanghai Children's Hospital, Shanghai Jiao Tong 
      University, Shanghai, China.
FAU - Li, Zhi-Ling
AU  - Li ZL
AD  - Department of Pediatrics, Luodian Hospital, Shanghai, China.
LA  - eng
PT  - Case Reports
PL  - China
TA  - Transl Pediatr
JT  - Translational pediatrics
JID - 101649179
EIN - Transl Pediatr. 2021 Oct;10(10):2881. PMID: 34765509
PMC - PMC8261580
OTO - NOTNLM
OT  - Case report
OT  - Stevens-Johnson syndrome (SJS)
OT  - drug gene testing
OT  - liver damage
COIS- Conflicts of Interest: All authors have completed the ICMJE uniform disclosure 
      form (available at http://dx.doi.org/10.21037/tp-21-8). The authors have no 
      conflicts of interest to declare.
EDAT- 2021/07/24 06:00
MHDA- 2021/07/24 06:01
PMCR- 2021/06/01
CRDT- 2021/07/23 06:51
PHST- 2021/01/07 00:00 [received]
PHST- 2021/04/23 00:00 [accepted]
PHST- 2021/07/23 06:51 [entrez]
PHST- 2021/07/24 06:00 [pubmed]
PHST- 2021/07/24 06:01 [medline]
PHST- 2021/06/01 00:00 [pmc-release]
AID - tp-10-06-1737 [pii]
AID - 10.21037/tp-21-8 [doi]
PST - ppublish
SO  - Transl Pediatr. 2021 Jun;10(6):1737-1742. doi: 10.21037/tp-21-8.