PMID- 34295822
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240402
IS  - 2234-943X (Print)
IS  - 2234-943X (Electronic)
IS  - 2234-943X (Linking)
VI  - 11
DP  - 2021
TI  - Improvement of Diabetes Mellitus After Colorectal Cancer Surgery: A Retrospective 
      Study of Predictive Factors For Type 2 Diabetes Mellitus Remission and Overall 
      Survival.
PG  - 694997
LID - 10.3389/fonc.2021.694997 [doi]
LID - 694997
AB  - PURPOSE: The purpose of the current study was to evaluate the impact of 
      colorectal cancer (CRC) surgery on type 2 diabetes mellitus (T2DM) and to analyze 
      the change in T2DM on overall survival after CRC surgery. METHODS: Patients who 
      underwent CRC surgery were retrospectively enrolled from January 2013 to December 
      2019. The status of T2DM pre- and 1-year after CRC surgery was recorded, and 
      predictive factors for T2DM remission and overall survival were analyzed. 
      RESULTS: A total of 296 patients were included in this study. Thirty-eight 
      patients experienced remission of T2DM 1 year after CRC surgery, and the 
      remission rate was 12.8%. Weight loss was significantly higher in the T2DM 
      remission group (p = 0.038), and the T2DM duration was significantly shorter in 
      the T2DM remission group (p = 0.015). In the multivariate logistic regression 
      analysis, higher weight loss (p = 0.046, odds ratio = 1.060, 95% CI = 
      1.001-1.122) and shorter T2DM duration (p = 0.019, odds ratio = 1007, 95% CI = 
      1.001-1.014) were predictive factors for remission of T2DM. Furthermore, in 
      multivariate Cox regression analysis, lower TNM stage (p = 0.000, odds ratio = 
      2.147, 95% CI = 1.474-3.128) and T2DM remission (p = 0.033, odds ratio = 2.999, 
      95% CI = 1.091-8.243) were the predictive factors for better overall survival. 
      CONCLUSION: Patients with concurrent CRC and T2DM had a 12.8% remission 1 year 
      after CRC surgery. Higher weight loss and shorter T2DM duration contributed to 
      T2DM remission, and patients with T2DM remission could improve in terms of their 
      overall survival.
CI  - Copyright (c) 2021 Peng, Liu, Cheng, Tao and Cheng.
FAU - Peng, Dong
AU  - Peng D
AD  - Department of Gastrointestinal Surgery, The First Affiliated Hospital of 
      Chongqing Medical University, Chongqing, China.
FAU - Liu, Xiao-Yu
AU  - Liu XY
AD  - Department of Gastrointestinal Surgery, The First Affiliated Hospital of 
      Chongqing Medical University, Chongqing, China.
FAU - Cheng, Yu-Xi
AU  - Cheng YX
AD  - Department of Gastrointestinal Surgery, The First Affiliated Hospital of 
      Chongqing Medical University, Chongqing, China.
FAU - Tao, Wei
AU  - Tao W
AD  - Department of Gastrointestinal Surgery, The First Affiliated Hospital of 
      Chongqing Medical University, Chongqing, China.
FAU - Cheng, Yong
AU  - Cheng Y
AD  - Department of Gastrointestinal Surgery, The First Affiliated Hospital of 
      Chongqing Medical University, Chongqing, China.
LA  - eng
PT  - Journal Article
DEP - 20210706
PL  - Switzerland
TA  - Front Oncol
JT  - Frontiers in oncology
JID - 101568867
PMC - PMC8290141
OTO - NOTNLM
OT  - colorectal cancer
OT  - overall survival
OT  - remission
OT  - surgery
OT  - type 2 diabetes mellitus
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2021/07/24 06:00
MHDA- 2021/07/24 06:01
PMCR- 2021/01/01
CRDT- 2021/07/23 06:51
PHST- 2021/04/14 00:00 [received]
PHST- 2021/05/31 00:00 [accepted]
PHST- 2021/07/23 06:51 [entrez]
PHST- 2021/07/24 06:00 [pubmed]
PHST- 2021/07/24 06:01 [medline]
PHST- 2021/01/01 00:00 [pmc-release]
AID - 10.3389/fonc.2021.694997 [doi]
PST - epublish
SO  - Front Oncol. 2021 Jul 6;11:694997. doi: 10.3389/fonc.2021.694997. eCollection 
      2021.