PMID- 34295964
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240402
IS  - 2366-3987 (Electronic)
IS  - 2366-3987 (Linking)
VI  - 3
IP  - 3
DP  - 2020 Mar
TI  - Collagenase-Cleavable Peptide Amphiphile Micelles as a Novel Theranostic Strategy 
      in Atherosclerosis.
LID - 1900196 [pii]
LID - 10.1002/adtp.201900196 [doi]
AB  - Atherosclerosis is an inflammatory disease characterized by plaques that can 
      cause sudden myocardial infarction upon rupture. Such rupture-prone plaques have 
      thin fibrous caps due to collagenase degradation, and a noninvasive diagnostic 
      tool and targeted therapy that can identify and treat vulnerable plaques and may 
      inhibit the onset of acute cardiac events. Toward this goal, monocyte-binding, 
      collagenase-inhibiting, and gadolinium-modified peptide amphiphile micelles (MCG 
      PAMs) are developed. Monocyte chemoattractant protein-1 (MCP-1) binds to C-C 
      chemokine receptor-2 expressed on pathological cell types present within plaques. 
      Through the peptide binding motif of MCP-1, MCG PAMs bind to monocytes and 
      vascular smooth muscle cells in vitro. Moreover, using magnetic resonance 
      imaging, MCG PAMs show enhanced targeting and successful detection of plaques in 
      diseased mice in vivo and act as contrast agents for molecular imaging. Through 
      the collagenase-cleaving peptide sequence of collagen [VPMS-MRGG], MCG PAMs can 
      compete for collagenases that degrade the fibrous cap of plaques, providing 
      therapy. MCG PAM-treated mice show increased fibrous cap thickness by 61% and 
      113% histologically compared to nontargeting micelle- or PBS-treated mice (p = 
      0.0075 and 0.001, respectively). Overall, this novel multimodal nanoparticle 
      offers new theranostic opportunities for noninvasive diagnosis and treatment of 
      atherosclerotic plaques.
FAU - Chin, Deborah D
AU  - Chin DD
AD  - Department of Biomedical Engineering, University of Southern California, Los 
      Angeles USC 90089 CA, USA.
FAU - Poon, Christopher
AU  - Poon C
AD  - Department of Biomedical Engineering, University of Southern California, Los 
      Angeles USC 90089 CA, USA.
FAU - Trac, Noah
AU  - Trac N
AD  - Department of Biomedical Engineering, University of Southern California, Los 
      Angeles USC 90089 CA, USA.
FAU - Wang, Jonathan
AU  - Wang J
AD  - Department of Biomedical Engineering, University of Southern California, Los 
      Angeles USC 90089 CA, USA.
FAU - Cook, Jackson
AU  - Cook J
AD  - Department of Biomedical Engineering, University of Southern California, Los 
      Angeles USC 90089 CA, USA.
FAU - Joo, Johan
AU  - Joo J
AD  - Department of Biomedical Engineering, University of Southern California, Los 
      Angeles USC 90089 CA, USA.
FAU - Jiang, Zhangjingyi
AU  - Jiang Z
AD  - Department of Biomedical Engineering, University of Southern California, Los 
      Angeles USC 90089 CA, USA.
FAU - Maria, Naomi Sulit Sta
AU  - Maria NSS
AD  - Department of Physiology and Neuroscience, Zilkha Neurogenetic, Institute and 
      Keck School of Medicine, University of Southern California, Los Angeles 90033 CA, 
      USA.
FAU - Jacobs, Russell E
AU  - Jacobs RE
AD  - Department of Physiology and Neuroscience, Zilkha Neurogenetic, Institute and 
      Keck School of Medicine, University of Southern California, Los Angeles 90033 CA, 
      USA.
FAU - Chung, Eun Ji
AU  - Chung EJ
AD  - Department of Biomedical Engineering, University of Southern California, Los 
      Angeles USC 90089 CA, USA.
LA  - eng
GR  - DP2 DK121328/DK/NIDDK NIH HHS/United States
GR  - R00 HL124279/HL/NHLBI NIH HHS/United States
PT  - Journal Article
DEP - 20200203
PL  - Germany
TA  - Adv Ther (Weinh)
JT  - Advanced therapeutics
JID - 101724632
PMC - PMC8294202
MID - NIHMS1630355
OTO - NOTNLM
OT  - atherosclerosis
OT  - collagen
OT  - magnetic resonance imaging
OT  - theranostic nanoparticle
OT  - vulnerable plaque
COIS- Conflict of Interest The authors declare no conflict of interest.
EDAT- 2020/03/01 00:00
MHDA- 2020/03/01 00:01
PMCR- 2021/07/21
CRDT- 2021/07/23 06:53
PHST- 2021/07/23 06:53 [entrez]
PHST- 2020/03/01 00:00 [pubmed]
PHST- 2020/03/01 00:01 [medline]
PHST- 2021/07/21 00:00 [pmc-release]
AID - 1900196 [pii]
AID - 10.1002/adtp.201900196 [doi]
PST - ppublish
SO  - Adv Ther (Weinh). 2020 Mar;3(3):1900196. doi: 10.1002/adtp.201900196. Epub 2020 
      Feb 3.