PMID- 34295985
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220425
IS  - 2392-1099 (Print)
IS  - 2449-8238 (Electronic)
IS  - 2392-1099 (Linking)
VI  - 7
IP  - 2
DP  - 2021 Jun
TI  - The association between juvenile autoimmune hepatitis and HLA-DRB1 alleles: Iraqi 
      tertiary center experience.
PG  - 178-182
LID - 10.5114/ceh.2021.106865 [doi]
AB  - AIM OF THE STUDY: To highlight the impact of the human leukocyte antigen (HLA) 
      allele on susceptibility and prevention of autoimmune hepatitis (AIH) in Iraqi 
      children. MATERIAL AND METHODS: We conducted a prospective study from children 
      attending the Gastroenterology and Hepatology Clinic of Children's Welfare 
      Teaching Hospital over five years from the first of September 2015 to the 
      thirty-first of August 2020. It included 19 patients with AIH; their age (at time 
      of diagnosis) ranged between 3 and 16 years, with a female predominance of 78.9%. 
      The diagnosis was made by clinical, serological, and histological features. In 
      addition, 20 age- and sex-matched unrelated subjects of the same ethnic 
      background were selected randomly from healthy individuals undergoing checkup as 
      controls. RESULTS: 19 patients diagnosed with AIH were included in this study, 
      and 20 age- and sex-matched healthy controls, with a female predominance of 
      78.9%. The commonest autoantibodies found were smooth muscle antibody (SMA) in 13 
      (68.4%), antinuclear antibody (ANA) in 11 (57.9%). In AIH type 1, PCR showed 
      higher frequencies among patients with HLA-DRB1*03, HLA-DRB1*04, HLA-DRB1*13 
      alleles in patients with AIH; moreover DRB1*11 and DRB1*15 were less frequent 
      than in the control group. Frequency of HLA-DRB1*04 was 28% and HLA-DRB1*13 was 
      20% in AIH type 2 patients; HLA-DRB1*13 and HLA-DRB5 showed frequency of 25% for 
      both and HLA-DRB4 frequency was 18.7%. CONCLUSIONS: HLA-DRB1*13, DRB1*04, and 
      DRB1*03 are susceptibility alleles for the development of AIH type 1, while 
      HLA-DRB1*13, HLA-DRB4 and DRB5 are susceptibility alleles for the development of 
      AIH type 2 in Iraqi children.
CI  - Copyright (c) 2021 Clinical and Experimental Hepatology.
FAU - Ibraheem, Mohammad Fadhil
AU  - Ibraheem MF
AD  - College of Medicine, University of Baghdad, Iraq.
FAU - Ahmed, Shaymaa Jamal
AU  - Ahmed SJ
AD  - College of Medicine, University of Baghdad, Iraq.
LA  - eng
PT  - Journal Article
DEP - 20210630
PL  - Poland
TA  - Clin Exp Hepatol
JT  - Clinical and experimental hepatology
JID - 101703431
PMC - PMC8284173
OTO - NOTNLM
OT  - HLA
OT  - Iraqi children
OT  - autoimmune hepatitis
OT  - clinical features
COIS- The authors declare no conflict of interest.
EDAT- 2021/07/24 06:00
MHDA- 2021/07/24 06:01
PMCR- 2021/06/01
CRDT- 2021/07/23 06:53
PHST- 2021/01/09 00:00 [received]
PHST- 2021/02/10 00:00 [accepted]
PHST- 2021/07/23 06:53 [entrez]
PHST- 2021/07/24 06:00 [pubmed]
PHST- 2021/07/24 06:01 [medline]
PHST- 2021/06/01 00:00 [pmc-release]
AID - 44373 [pii]
AID - 10.5114/ceh.2021.106865 [doi]
PST - ppublish
SO  - Clin Exp Hepatol. 2021 Jun;7(2):178-182. doi: 10.5114/ceh.2021.106865. Epub 2021 
      Jun 30.