PMID- 34296178
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240402
IS  - 2632-7376 (Electronic)
IS  - 2632-7376 (Linking)
VI  - 2
IP  - 2
DP  - 2021
TI  - Electrophysiological Correlates of Rodent Default-Mode Network Suppression 
      Revealed by Large-Scale Local Field Potential Recordings.
PG  - tgab034
LID - 10.1093/texcom/tgab034 [doi]
LID - tgab034
AB  - The default-mode network (DMN) in humans consists of a set of brain regions that, 
      as measured with functional magnetic resonance imaging (fMRI), show both 
      intrinsic correlations with each other and suppression during externally oriented 
      tasks. Resting-state fMRI studies have previously identified similar patterns of 
      intrinsic correlations in overlapping brain regions in rodents (A29C/posterior 
      cingulate cortex, parietal cortex, and medial temporal lobe structures). However, 
      due to challenges with performing rodent behavior in an MRI machine, it is still 
      unclear whether activity in rodent DMN regions are suppressed during externally 
      oriented visual tasks. Using distributed local field potential measurements in 
      rats, we have discovered that activity in DMN brain regions noted above show 
      task-related suppression during an externally oriented visual task at alpha and 
      low beta-frequencies. Interestingly, this suppression (particularly in posterior 
      cingulate cortex) was linked with improved performance on the task. Using 
      electroencephalography recordings from a similar task in humans, we identified a 
      similar suppression of activity in posterior cingulate cortex at alpha/low 
      beta-frequencies. Thus, we have identified a common electrophysiological marker 
      of DMN suppression in both rodents and humans. This observation paves the way for 
      future studies using rodents to probe circuit-level functioning of DMN function. 
      SIGNIFICANCE: Here we show that alpha/beta frequency oscillations in rats show 
      key features of DMN activity, including intrinsic correlations between DMN brain 
      regions, task-related suppression, and interference with 
      attention/decision-making. We found similar task-related suppression at alpha/low 
      beta-frequencies of DMN activity in humans.
CI  - Published by Oxford University Press 2021.
FAU - Fakhraei, Leila
AU  - Fakhraei L
AD  - Mental Health Service, VA San Diego Healthcare System., La Jolla, CA 92161, USA.
FAU - Francoeur, Miranda
AU  - Francoeur M
AD  - Mental Health Service, VA San Diego Healthcare System., La Jolla, CA 92161, USA.
FAU - Balasubramani, Pragathi P
AU  - Balasubramani PP
AD  - Department of Psychiatry, UC San Diego, La Jolla, CA 92093, USA.
FAU - Tang, Tianzhi
AU  - Tang T
AD  - Mental Health Service, VA San Diego Healthcare System., La Jolla, CA 92161, USA.
FAU - Hulyalkar, Sidharth
AU  - Hulyalkar S
AD  - Mental Health Service, VA San Diego Healthcare System., La Jolla, CA 92161, USA.
FAU - Buscher, Nathalie
AU  - Buscher N
AD  - Mental Health Service, VA San Diego Healthcare System., La Jolla, CA 92161, USA.
FAU - Mishra, Jyoti
AU  - Mishra J
AD  - Department of Psychiatry, UC San Diego, La Jolla, CA 92093, USA.
FAU - Ramanathan, Dhakshin S
AU  - Ramanathan DS
AD  - Mental Health Service, VA San Diego Healthcare System., La Jolla, CA 92161, USA.
LA  - eng
GR  - IK2 BX003308/BX/BLRD VA/United States
PT  - Journal Article
DEP - 20210505
PL  - United States
TA  - Cereb Cortex Commun
JT  - Cerebral cortex communications
JID - 101767128
PMC - PMC8166125
OTO - NOTNLM
OT  - DMN
OT  - alpha
OT  - local field potentials
OT  - posterior cingulate
OT  - task-related interference
EDAT- 2021/07/24 06:00
MHDA- 2021/07/24 06:01
PMCR- 2021/05/05
CRDT- 2021/07/23 06:55
PHST- 2021/03/14 00:00 [received]
PHST- 2021/04/13 00:00 [revised]
PHST- 2021/04/14 00:00 [accepted]
PHST- 2021/07/23 06:55 [entrez]
PHST- 2021/07/24 06:00 [pubmed]
PHST- 2021/07/24 06:01 [medline]
PHST- 2021/05/05 00:00 [pmc-release]
AID - tgab034 [pii]
AID - 10.1093/texcom/tgab034 [doi]
PST - epublish
SO  - Cereb Cortex Commun. 2021 May 5;2(2):tgab034. doi: 10.1093/texcom/tgab034. 
      eCollection 2021.