PMID- 34296390
OWN - NLM
STAT- MEDLINE
DCOM- 20211122
LR  - 20221207
IS  - 1559-0100 (Electronic)
IS  - 1355-008X (Linking)
VI  - 74
IP  - 3
DP  - 2021 Dec
TI  - The relationship between the level of exercise and hemoglobin A(1)c in patients 
      with type 2 diabetes mellitus: a systematic review and meta-analysis.
PG  - 546-558
LID - 10.1007/s12020-021-02817-8 [doi]
AB  - PURPOSE: The aim of the study was to evaluate the relationship between changes in 
      hemoglobin A(1)c (HbA(1c)) and exercise levels in type 2 diabetes mellitus (T2DM) 
      patients when performing various types of exercise. METHODS: The inclusion 
      criteria were randomized controlled trials involving adults with T2DM, 
      intervention involving exercise alone, the overall duration of intervention >/=12 
      weeks, and reporting HbA(1c). Weighted mean difference (WMD) was defined as the 
      mean difference between the intervention group and the control group weighted by 
      the inverse of the squared standard error for each study, and all WMDs were 
      pooled as overall effects. A meta-regression analysis was performed to evaluate 
      the relationship between the exercise level and the WMD in HbA(1c). RESULTS: 
      Forty-eight studies (2395 subjects) were analyzed. The pooled WMD in HbA(1c) 
      decreased significantly (-0.5% [95% confidence intervals: -0.6 to -0.4]) but 
      contained significant heterogeneity (Q = 103.8, P < 0.01; I(2) = 36.6%). A 
      meta-regression analysis showed that the intensity (metabolic equivalents 
      [METs]), time (min/session), or frequency (sessions/week) of the exercise was not 
      associated with the HbA(1c). However, the overall duration of exercise (weeks) 
      was significantly associated with the WMD in HbA(1c) (meta-regression 
      coefficient: 0.01 [95% confidence intervals: 0.002-0.016]; R(2) = 70.0%), and 
      that result did not contain significant heterogeneity (P > 0.05; I(2) = 14.7%). 
      CONCLUSIONS: The exercise intervention decreases HbA(1c) in T2DM patients. In 
      addition, exercise for an extended duration was associated with an increase in 
      HbA(1c), so the effects of exercise may be evident early on, but results 
      suggested that exercise for a prolonged period alone may increase HbA(1c).
CI  - (c) 2021. The Author(s), under exclusive licence to Springer Science+Business 
      Media, LLC, part of Springer Nature.
FAU - Igarashi, Yutaka
AU  - Igarashi Y
AUID- ORCID: 0000-0003-0012-4225
AD  - Osaka City University, Osaka, 558-8585, Japan. yu_igarashi_000@mail.goo.ne.jp.
FAU - Akazawa, Nobuhiko
AU  - Akazawa N
AD  - Japan Institute of Sports Sciences, Tokyo, 115-0056, Japan.
AD  - Faculty of Health and Sport Sciences, University of Tsukuba, Ibaraki, 305-8574, 
      Japan.
FAU - Maeda, Seiji
AU  - Maeda S
AD  - Faculty of Health and Sport Sciences, University of Tsukuba, Ibaraki, 305-8574, 
      Japan.
AD  - Faculty of Sport Sciences, Waseda University, Saitama, 359-1192, Japan.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Systematic Review
DEP - 20210723
PL  - United States
TA  - Endocrine
JT  - Endocrine
JID - 9434444
RN  - 0 (Blood Glucose)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Hemoglobin, Sickle)
RN  - 52012-19-8 (hemoglobin AS)
SB  - IM
MH  - Adult
MH  - Blood Glucose
MH  - *Diabetes Mellitus, Type 2/therapy
MH  - Exercise
MH  - Glycated Hemoglobin/analysis
MH  - Hemoglobin, Sickle
MH  - Humans
MH  - Randomized Controlled Trials as Topic
OTO - NOTNLM
OT  - Form of exercise
OT  - Meta-regression analysis
OT  - Randomized controlled trials
EDAT- 2021/07/24 06:00
MHDA- 2021/11/23 06:00
CRDT- 2021/07/23 07:04
PHST- 2021/04/12 00:00 [received]
PHST- 2021/06/25 00:00 [accepted]
PHST- 2021/07/24 06:00 [pubmed]
PHST- 2021/11/23 06:00 [medline]
PHST- 2021/07/23 07:04 [entrez]
AID - 10.1007/s12020-021-02817-8 [pii]
AID - 10.1007/s12020-021-02817-8 [doi]
PST - ppublish
SO  - Endocrine. 2021 Dec;74(3):546-558. doi: 10.1007/s12020-021-02817-8. Epub 2021 Jul 
      23.