PMID- 34296589
OWN - NLM
STAT- MEDLINE
DCOM- 20210726
LR  - 20210726
IS  - 1001-5302 (Print)
IS  - 1001-5302 (Linking)
VI  - 46
IP  - 11
DP  - 2021 Jun
TI  - [Non-targeted metabolomics study and biomarker screening of prehypertensive 
      liver-fire hyperactivity syndrome based on UPLC-Q-Exactive MS technology].
PG  - 2881-2888
LID - 10.19540/j.cnki.cjcmm.20210323.201 [doi]
AB  - In this study, patients with prehypertensive liver-fire hyperactivity 
      syndrome(LFHS) were selected as the research objects. The plasma samples of 
      healthy volunteers and patients with prehypertensive LFHS were analyzed by 
      non-targeted metabolomics based on UPLC-Q-Exactive MS. The differential 
      biomarkers and metabolic pathways were screened out by multivariate statistics 
      and metabolic pathway analysis, which revealed the characteristics of metabolic 
      patterns of the syndrome. Thirty-three potential biomarkers such as androsterone 
      and lysophosphatidylcholine and 16 related metabolic pathways such as steroid 
      hormone metabolism and lipid metabolism were identified, and a partial least 
      squares-discriminant analysis(PLS-DA) model of traditional Chinese medicine(TCM) 
      syndromes was preliminarily constructed: Y =-0.070X_(13)-0.006X_8+ 
      0.040X_5-0.152X_1+0.131X_(10)+0.036X_(11)+0.043X_(23)+0.076X_(16)+0.132X_(20)+0.081X_(19)-0.101X_(31)+0.082X_(15)-0.038X_9+0.079X_(24). 
      The predictive value of the model was 88.1%, and the explanatory power was 88.4%. 
      In this study, the characteristic metabolic pattern of the prehypertensive LFHS 
      was distinguished and revealed by metabolomics. The constructed PLS-DA model is 
      expected to provide an objective basis for the identification of TCM syndromes in 
      prehypertension, and inspiration for exploring the biological basis of TCM 
      syndromes at small-molecular and overall levels.
FAU - Wang, Yu
AU  - Wang Y
AD  - Affiliated Hospital of Shandong University of Traditional Chinese Medicine Ji'nan 
      250011, China.
FAU - Li, Shu-Min
AU  - Li SM
AD  - Shandong University of Traditional Chinese Medicine Ji'nan 250355, China.
FAU - Li, Chao
AU  - Li C
AD  - Shandong University of Traditional Chinese Medicine Ji'nan 250355, China.
FAU - Yang, Wen-Qing
AU  - Yang WQ
AD  - Shandong University of Traditional Chinese Medicine Ji'nan 250355, China.
FAU - Li, Yun-Lun
AU  - Li YL
AD  - Affiliated Hospital of Shandong University of Traditional Chinese Medicine Ji'nan 
      250011, China Shandong University of Traditional Chinese Medicine Ji'nan 250355, 
      China.
LA  - chi
PT  - Journal Article
PL  - China
TA  - Zhongguo Zhong Yao Za Zhi
JT  - Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese 
      materia medica
JID - 8913656
RN  - 0 (Biomarkers)
SB  - IM
MH  - Biomarkers
MH  - Chromatography, High Pressure Liquid
MH  - Humans
MH  - *Liver
MH  - *Metabolomics
MH  - Syndrome
MH  - Technology
OTO - NOTNLM
OT  - liver-fire hyperactivity syndrome(LFHS)
OT  - metabolomics
OT  - prehypertension
EDAT- 2021/07/24 06:00
MHDA- 2021/07/27 06:00
CRDT- 2021/07/23 07:17
PHST- 2021/07/23 07:17 [entrez]
PHST- 2021/07/24 06:00 [pubmed]
PHST- 2021/07/27 06:00 [medline]
AID - 10.19540/j.cnki.cjcmm.20210323.201 [doi]
PST - ppublish
SO  - Zhongguo Zhong Yao Za Zhi. 2021 Jun;46(11):2881-2888. doi: 
      10.19540/j.cnki.cjcmm.20210323.201.