PMID- 34297534
OWN - NLM
STAT- MEDLINE
DCOM- 20210903
LR  - 20210903
IS  - 1948-7193 (Electronic)
IS  - 1948-7193 (Linking)
VI  - 12
IP  - 15
DP  - 2021 Aug 4
TI  - Activation of Cellular Antioxidant Defense System by Naturally Occurring 
      Dibenzopyrone Derivatives Confers Neuroprotection against Oxidative Insults.
PG  - 2798-2809
LID - 10.1021/acschemneuro.1c00023 [doi]
AB  - Seven dibenzopyrone phenolic derivatives, i.e., alternariol (1), alternariol 
      5-O-methyl ether (2), altenusin B (3), dehydroaltenusin (4), altenuene (5), 
      altenusin (6), and alterlactone (7), were isolated from endophytic fungi 
      Alternaria alternata extract, and these compounds' structures were elucidated 
      based on various spectroscopic data. Compound 3, a diphenic acid derivative, was 
      determined as a new compound. In this study, compounds 3, 4, 6, and 7 displayed 
      remarkable neuroprotective effects against oxidative injuries by acting as potent 
      activators of nuclear factor-erythroid derived 2-like 2 (Nrf2) in PC12 cells. A 
      mechanistic study indicated that these compounds induced the nuclear accumulation 
      of Nrf2, promoted the expression of Nrf2-governed cytoprotective genes, and 
      increased the cellular antioxidant capacity. More importantly, genetic silence of 
      Nrf2 expression deprived the observed cytoprotection, highlighting the important 
      role of Nrf2 in the protection of these compounds.
FAU - Hou, Yanan
AU  - Hou Y
AUID- ORCID: 0000-0003-0426-8795
AD  - State Key Laboratory of Applied Organic Chemistry and College of Chemistry and 
      Chemical Engineering, Lanzhou University, Lanzhou 730000, China.
FAU - Li, Jie
AU  - Li J
AD  - State Key Laboratory of Applied Organic Chemistry and College of Chemistry and 
      Chemical Engineering, Lanzhou University, Lanzhou 730000, China.
FAU - Wu, Jun-Chen
AU  - Wu JC
AD  - State Key Laboratory of Applied Organic Chemistry and College of Chemistry and 
      Chemical Engineering, Lanzhou University, Lanzhou 730000, China.
FAU - Wu, Quan-Xiang
AU  - Wu QX
AUID- ORCID: 0000-0002-1895-5417
AD  - State Key Laboratory of Applied Organic Chemistry and College of Chemistry and 
      Chemical Engineering, Lanzhou University, Lanzhou 730000, China.
FAU - Fang, Jianguo
AU  - Fang J
AUID- ORCID: 0000-0002-2884-3363
AD  - State Key Laboratory of Applied Organic Chemistry and College of Chemistry and 
      Chemical Engineering, Lanzhou University, Lanzhou 730000, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210723
PL  - United States
TA  - ACS Chem Neurosci
JT  - ACS chemical neuroscience
JID - 101525337
RN  - 0 (Antioxidants)
RN  - 0 (NF-E2-Related Factor 2)
RN  - Alternaria alternata
SB  - IM
MH  - Alternaria
MH  - Animals
MH  - *Antioxidants/pharmacology
MH  - NF-E2-Related Factor 2/metabolism
MH  - *Neuroprotection
MH  - Oxidative Stress
MH  - PC12 Cells
MH  - Rats
OTO - NOTNLM
OT  - Nrf2
OT  - antioxidant
OT  - dibenzopyrone derivatives
OT  - neuroprotective effect
OT  - oxidative stress
EDAT- 2021/07/24 06:00
MHDA- 2021/09/04 06:00
CRDT- 2021/07/23 17:09
PHST- 2021/07/24 06:00 [pubmed]
PHST- 2021/09/04 06:00 [medline]
PHST- 2021/07/23 17:09 [entrez]
AID - 10.1021/acschemneuro.1c00023 [doi]
PST - ppublish
SO  - ACS Chem Neurosci. 2021 Aug 4;12(15):2798-2809. doi: 
      10.1021/acschemneuro.1c00023. Epub 2021 Jul 23.