PMID- 34297780
OWN - NLM
STAT- MEDLINE
DCOM- 20211108
LR  - 20211108
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 16
IP  - 7
DP  - 2021
TI  - The relationship between common mental disorders and incident diabetes among 
      participants in the Kerala Diabetes Prevention Program (K-DPP).
PG  - e0255217
LID - 10.1371/journal.pone.0255217 [doi]
LID - e0255217
AB  - This study aims to describe the prevalence of depression and anxiety among a 
      population sample of people at high risk for type 2 diabetes in Kerala, India, 
      and examine the relationship between depressive symptoms, anxiety, and incident 
      Type 2 Diabetes Mellitus (T2DM) over a two-year period. We used data from the 
      Kerala Diabetes Prevention Program, a cluster-randomized controlled trial for 
      diabetes prevention among 1007 high-risk individuals. The prevalence of 
      depression and anxiety were estimated using the 9-item Patient Health 
      Questionnaire and the Generalized Anxiety Disorder 7-item scale, respectively. We 
      calculated proportions for depression and anxiety and performed generalized 
      estimating equations (GEE) to examine the relationship between baseline mental 
      health status and incident T2DM. The prevalence of depression and anxiety at 
      baseline were 7.5% and 5.5%, respectively. Compared with those reporting none/low 
      symptoms, the odds ratio for incident diabetes was 1.07 (95% CI 0.54-2.12) for 
      participants with moderate to severe depression and 0.73 (95% CI 0.23-2.28) for 
      participants with moderate to severe anxiety, after adjusting for potential 
      confounders. Our findings suggest that the prevalence of depression and anxiety 
      were higher than those previously reported in the general population in India. 
      However, among this sample of community-based adults at high risk of developing 
      T2DM, the presence of moderate to severe depression and/or anxiety symptoms was 
      not significantly associated with the risk of developing T2DM. Trial 
      registration: Australia and New Zealand Clinical Trials Registry 
      ACTRN12611000262909. Registered 10 March 2011.
FAU - Johnson, Leslie C M
AU  - Johnson LCM
AUID- ORCID: 0000-0003-4574-847X
AD  - Department of Family and Preventive Medicine, School of Medicine, Emory 
      University, Atlanta, Georgia, United States of America.
AD  - Hubert Department of Global Health, Rollins School of Public Health, Emory 
      University, Atlanta, Georgia, United States of America.
FAU - Desloge, Allissa
AU  - Desloge A
AD  - School of Population and Global Health, University of Melbourne, Melbourne, 
      Australia.
AD  - MacMillan Center for International and Area Studies, Yale University, New Haven, 
      Connecticut, United States of America.
FAU - Sathish, Thirunavukkarasu
AU  - Sathish T
AD  - School of Population and Global Health, University of Melbourne, Melbourne, 
      Australia.
AD  - Population Health Research Institute, McMaster University, Hamilton, Ontario, 
      Canada.
FAU - Williams, Emily D
AU  - Williams ED
AUID- ORCID: 0000-0002-9399-1960
AD  - School of Health Sciences, University of Surrey, Guildford, United Kingdom.
FAU - Absetz, Pilvikki
AU  - Absetz P
AUID- ORCID: 0000-0002-1047-909X
AD  - Collaborative Care Systems Finland, Tampere University, Tampere, Finland.
FAU - Haregu, Tilahun
AU  - Haregu T
AD  - School of Population and Global Health, University of Melbourne, Melbourne, 
      Australia.
FAU - De Man, Jeroen
AU  - De Man J
AUID- ORCID: 0000-0002-3196-8757
AD  - Centre for General Practice, Department of Primary and Interdisciplinary Care, 
      University of Antwerp, Antwerp, Belgium.
FAU - Thankappan, Kavumpurathu Raman
AU  - Thankappan KR
AUID- ORCID: 0000-0002-4536-2684
AD  - Department of Public Health and Community Medicine, Central University of Kerala, 
      Kasaragod, India.
FAU - Oldenburg, Brian
AU  - Oldenburg B
AD  - School of Population and Global Health, University of Melbourne, Melbourne, 
      Australia.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20210723
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Adult
MH  - Anxiety/*epidemiology
MH  - Depression/*epidemiology
MH  - Diabetes Mellitus, Type 2/*epidemiology
MH  - Female
MH  - Humans
MH  - India
MH  - Male
MH  - Mental Health/statistics & numerical data
MH  - Middle Aged
MH  - Prevalence
PMC - PMC8301665
COIS- The authors have declared that no competing interests exist.
EDAT- 2021/07/24 06:00
MHDA- 2021/11/09 06:00
PMCR- 2021/07/23
CRDT- 2021/07/23 17:20
PHST- 2020/09/04 00:00 [received]
PHST- 2021/07/08 00:00 [accepted]
PHST- 2021/07/23 17:20 [entrez]
PHST- 2021/07/24 06:00 [pubmed]
PHST- 2021/11/09 06:00 [medline]
PHST- 2021/07/23 00:00 [pmc-release]
AID - PONE-D-20-27911 [pii]
AID - 10.1371/journal.pone.0255217 [doi]
PST - epublish
SO  - PLoS One. 2021 Jul 23;16(7):e0255217. doi: 10.1371/journal.pone.0255217. 
      eCollection 2021.