PMID- 34297937 OWN - NLM STAT- MEDLINE DCOM- 20211117 LR - 20240214 IS - 1096-0953 (Electronic) IS - 0013-9351 (Print) IS - 0013-9351 (Linking) VI - 202 DP - 2021 Nov TI - Acute ambient air pollution exposure and placental Doppler results in the NICHD fetal growth studies - Singleton cohort. PG - 111728 LID - S0013-9351(21)01022-7 [pii] LID - 10.1016/j.envres.2021.111728 [doi] AB - BACKGROUND: Increased placental vascular resistance is a proposed mechanism by which air pollution exposure during pregnancy lowers birth weight and increases pregnancy-induced hypertensive disorders. OBJECTIVE: To examine the impact of acute air pollution exposure during pregnancy on uterine and umbilical artery Doppler indicators of placental vascular resistance. METHODS: After a first ultrasound to confirm gestational age, 2562 pregnant women recruited in 12 clinics throughout the United States underwent up to five standardized ultrasounds with Doppler measurements. Exposures to 11 air pollutants were estimated for the hour of ultrasound and each of the 2 h prior to ultrasound at the clinics using the National Air Quality Forecast Capability reanalysis products. We used mixed logistic regression to study the longitudinal odds ratio (OR) of any, uni- or bi-lateral systolic and diastolic uterine artery notching compared to no notching and the longitudinal OR of abnormal end diastolic flow of the umbilical artery compared to forward flow. Uterine and umbilical artery resistance indexes were studied using linear mixed models. RESULTS: Each inter-quartile range (IQR) increase of particulate matter < 2.5 mum, nitrate, ammonium, primary organic matter (POM) and nitrogen dioxide during the hour of ultrasound was associated with a decreased risk of unilateral systolic notch and with increased resistance index of the left uterine artery. For the umbilical artery, each IQR increase in ozone was associated with decreased resistance index (b: -0.26, 95 % CI: -0.52, -0.01) and with a decreased risk of abnormal end diastolic flow (OR: 0.36, 95 % CI: 0.14, 0.94); while each IQR increase of elemental carbon and POM was associated with increased risk of abnormal end diastolic flow (OR: 1.47, 95 % CI: 1.02, 2.13 and OR: 1.67, 95 % CI: 1.17, 2.39, respectively). DISCUSSION: Our results suggest acute air pollution exposure may influence placental vascular resistance. CI - Published by Elsevier Inc. FAU - Ouidir, Marion AU - Ouidir M AD - Epidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD, USA. FAU - Tekola-Ayele, Fasil AU - Tekola-Ayele F AD - Epidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD, USA. FAU - Canty, Timothy AU - Canty T AD - Department of Atmospheric and Oceanic Science, University of Maryland, College Park, MD, USA. FAU - Grantz, Katherine L AU - Grantz KL AD - Epidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD, USA. FAU - Sciscione, Anthony AU - Sciscione A AD - Department of Obstetrics and Gynecology, Christiana Care Health System, Newark, DE, USA. FAU - Tong, Daniel AU - Tong D AD - Center for Spatial Science and Systems, George Mason University, Fairfax, VA, USA. FAU - Jones, Rena R AU - Jones RR AD - Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA. FAU - Sundaram, Rajeshwari AU - Sundaram R AD - Biostatistics and Bioinformatics Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD, USA. FAU - Williams, Andrew AU - Williams A AD - University of North Dakota, School of Medicine & Health Sciences, Grand Forks, ND, USA. FAU - Stevens, Danielle AU - Stevens D AD - Epidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD, USA. FAU - Mendola, Pauline AU - Mendola P AD - Epidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD, USA; Department of Epidemiology and Environmental Health, School of Public Health and Health Professions, University at Buffalo, Buffalo, NY, USA. Electronic address: pmendola@buffalo.edu. LA - eng GR - HHSN275200800014C/HD/NICHD NIH HHS/United States GR - HHSN275200800031C/HD/NICHD NIH HHS/United States GR - HHSN275200800002C/HD/NICHD NIH HHS/United States GR - HHSN275200800013C/HD/NICHD NIH HHS/United States GR - HHSN275200800012C/HD/NICHD NIH HHS/United States GR - HHSN275200800003I/HD/NICHD NIH HHS/United States GR - HHSN275200800003C/HD/NICHD NIH HHS/United States GR - HHSN275201000009C/HD/NICHD NIH HHS/United States GR - HHSN275200800002I/HD/NICHD NIH HHS/United States GR - HHSN275200800028C/HD/NICHD NIH HHS/United States PT - Journal Article PT - Research Support, American Recovery and Reinvestment Act PT - Research Support, N.I.H., Extramural PT - Research Support, N.I.H., Intramural DEP - 20210721 PL - Netherlands TA - Environ Res JT - Environmental research JID - 0147621 RN - 0 (Air Pollutants) SB - IM MH - *Air Pollutants/analysis/toxicity MH - *Air Pollution/analysis/statistics & numerical data MH - Female MH - Fetal Development MH - Humans MH - National Institute of Child Health and Human Development (U.S.) MH - Placenta/chemistry/diagnostic imaging MH - Pregnancy MH - Umbilical Arteries/chemistry/diagnostic imaging MH - United States PMC - PMC8578287 MID - NIHMS1727845 OTO - NOTNLM OT - Air pollution OT - Ozone OT - Particulate matter OT - Placenta OT - Ultrasound Doppler OT - Uterine artery notch OT - Vascular resistance COIS- Competing Financial Interests: The authors declare they have no actual or potential competing financial interests. EDAT- 2021/07/24 06:00 MHDA- 2021/11/18 06:00 PMCR- 2022/11/01 CRDT- 2021/07/23 20:10 PHST- 2021/02/25 00:00 [received] PHST- 2021/06/21 00:00 [revised] PHST- 2021/07/16 00:00 [accepted] PHST- 2021/07/24 06:00 [pubmed] PHST- 2021/11/18 06:00 [medline] PHST- 2021/07/23 20:10 [entrez] PHST- 2022/11/01 00:00 [pmc-release] AID - S0013-9351(21)01022-7 [pii] AID - 10.1016/j.envres.2021.111728 [doi] PST - ppublish SO - Environ Res. 2021 Nov;202:111728. doi: 10.1016/j.envres.2021.111728. Epub 2021 Jul 21.