PMID- 34297994
OWN - NLM
STAT- MEDLINE
DCOM- 20220318
LR  - 20221003
IS  - 1872-6240 (Electronic)
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 1768
DP  - 2021 Oct 1
TI  - Morphological alteration in rat hippocampal neuronal dendrites following chronic 
      binge prenatal alcohol exposure.
PG  - 147587
LID - S0006-8993(21)00444-3 [pii]
LID - 10.1016/j.brainres.2021.147587 [doi]
AB  - Prenatal alcohol exposure (PAE) may result in Fetal Alcohol Spectrum Disorders 
      (FASD). The hippocampus has been recognized as a vulnerable target to 
      alcohol-induced developmental damage. However, the effect of prenatal exposure to 
      alcohol on dendritic morphological adaptations throughout the hippocampal fields 
      in the developing brain still remains largely unknown in the context of FASD. We 
      hypothesized that chronic binge alcohol exposure during pregnancy alters dendrite 
      arborization throughout the developing rat hippocampus. Pregnant Sprague-Dawley 
      rats were assigned to either a pair-fed control (PF-Cont) or a binge alcohol 
      (Alcohol) treatment group. Alcohol dams were acclimatized via a once-daily 
      orogastric gavage of 4.5 g/kg alcohol from gestational day (GD) 5-10 and 
      progressed to 6 g/kg alcohol from GD 11-21. Pair-fed dams similarly received 
      isocaloric maltose dextrin. After parturition, all dams received an ad libitum 
      diet and nursed their offspring until postnatal day (PND) 10 when the pup brains 
      were collected for morphological analysis. PAE increased dendritic arborization 
      and complexities of CA1, CA2/3, and DG neurons in the PND 10 rat hippocampus. The 
      number of primary dendrites, total dendritic length, and number of dendritic 
      branches were significantly increased following PAE, and Sholl analysis revealed 
      significantly more intersections of the dendritic processes in PND 10 offspring 
      following PAE compared with those in the PF-Cont group. We conclude that chronic 
      binge PAE significantly alters hippocampal dendritic morphology in the developing 
      hippocampus. We conjecture that this morphological alteration in postnatal rat 
      hippocampal dendrites following chronic binge prenatal alcohol exposure may play 
      a critical role in FASD neurobiological phenotypes.
CI  - Copyright (c) 2021 Elsevier B.V. All rights reserved.
FAU - Lee, Jehoon
AU  - Lee J
AD  - Department of Veterinary Physiology and Pharmacology, College of Veterinary 
      Medicine and Biomedical Sciences, Texas A&M University, College Station, TX 
      77843, USA.
FAU - Naik, Vishal
AU  - Naik V
AD  - Department of Veterinary Physiology and Pharmacology, College of Veterinary 
      Medicine and Biomedical Sciences, Texas A&M University, College Station, TX 
      77843, USA.
FAU - Orzabal, Marcus
AU  - Orzabal M
AD  - Department of Veterinary Physiology and Pharmacology, College of Veterinary 
      Medicine and Biomedical Sciences, Texas A&M University, College Station, TX 
      77843, USA.
FAU - Lunde-Young, Raine
AU  - Lunde-Young R
AD  - Department of Veterinary Physiology and Pharmacology, College of Veterinary 
      Medicine and Biomedical Sciences, Texas A&M University, College Station, TX 
      77843, USA.
FAU - Ramadoss, Jayanth
AU  - Ramadoss J
AD  - Department of Veterinary Physiology and Pharmacology, College of Veterinary 
      Medicine and Biomedical Sciences, Texas A&M University, College Station, TX 
      77843, USA. Electronic address: jramadoss@cvm.tamu.edu.
LA  - eng
GR  - R01 HL151497/HL/NHLBI NIH HHS/United States
GR  - R00 AA019446/AA/NIAAA NIH HHS/United States
GR  - K99 AA019446/AA/NIAAA NIH HHS/United States
GR  - R21 AA023035/AA/NIAAA NIH HHS/United States
GR  - R01 AA023520/AA/NIAAA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20210720
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 3K9958V90M (Ethanol)
SB  - IM
MH  - Alcohol Drinking/*adverse effects
MH  - Animals
MH  - Dendrites/drug effects/*metabolism
MH  - Ethanol/pharmacology
MH  - Female
MH  - Fetal Alcohol Spectrum Disorders/physiopathology
MH  - Hippocampus/*drug effects/metabolism
MH  - Male
MH  - Neurons/drug effects/metabolism
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects/chemically induced/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
PMC - PMC8403165
MID - NIHMS1727835
OTO - NOTNLM
OT  - Alcohol
OT  - Arborization
OT  - Dendrites
OT  - FASD
OT  - Fetal
OT  - Hippocampus
COIS- Declarations of interest: None
EDAT- 2021/07/24 06:00
MHDA- 2022/03/19 06:00
PMCR- 2022/10/01
CRDT- 2021/07/23 20:11
PHST- 2021/03/26 00:00 [received]
PHST- 2021/06/15 00:00 [revised]
PHST- 2021/07/16 00:00 [accepted]
PHST- 2021/07/24 06:00 [pubmed]
PHST- 2022/03/19 06:00 [medline]
PHST- 2021/07/23 20:11 [entrez]
PHST- 2022/10/01 00:00 [pmc-release]
AID - S0006-8993(21)00444-3 [pii]
AID - 10.1016/j.brainres.2021.147587 [doi]
PST - ppublish
SO  - Brain Res. 2021 Oct 1;1768:147587. doi: 10.1016/j.brainres.2021.147587. Epub 2021 
      Jul 20.