PMID- 34298243
OWN - NLM
STAT- MEDLINE
DCOM- 20211020
LR  - 20211020
IS  - 2666-6367 (Electronic)
IS  - 2666-6367 (Linking)
VI  - 27
IP  - 10
DP  - 2021 Oct
TI  - A Prospective Viral Monitoring Study After Pediatric Allogeneic Hematopoietic 
      Stem Cell Transplantation for Malignant and Nonmalignant Diseases.
PG  - 872.e1-872.e8
LID - S2666-6367(21)01079-4 [pii]
LID - 10.1016/j.jtct.2021.07.014 [doi]
AB  - Allogeneic hematopoietic stem cell transplantation (HSCT) is the treatment of 
      choice for many high-risk pediatric hematological malignant diseases (MD) and 
      several nonmalignant diseases (NMD), including primary immune deficiencies. 
      Infections must be managed to obtain better outcomes after HSCT. In this 
      prospective observational study, viral monitoring was performed on 74 pediatric 
      patients with MD and NMD who underwent HSCT. The incidence, risk factors, and 
      impact of common opportunistic viral infections occurring within the first 100 
      days following HSCT were assessed. The viral pathogens included human 
      herpesviruses, BK polyomavirus (BKV), adenovirus, parvovirus B19, and hepatitis B 
      virus. In total, 52 (70%) patients had viral DNAemia, and 53% and 41% of patients 
      developed human herpesvirus 6 (HHV-6) and cytomegalovirus (CMV) DNAemia, 
      respectively. The risk factors were as follows: negative CMV serology for any 
      viral infections; age >/= 2 years and negative CMV serology for HHV-6; age >/=5 years 
      and female sex for BKV. The risk of viral infection did not significantly differ 
      between MD and NMD, and no risk factor was identified for viral disease, likely 
      because of the small sample numbers. However, despite the absence of symptoms, 
      CMV DNAemia was found to increase the risk of mortality. The findings of the 
      current study could improve the risk stratification and the management of 
      pediatric HSCT recipients.
CI  - Copyright (c) 2021 The American Society for Transplantation and Cellular Therapy. 
      Published by Elsevier Inc. All rights reserved.
FAU - Yamada, Masaki
AU  - Yamada M
AD  - Advanced Medicine for Viral Infections, National Center for Child Health and 
      Development, Tokyo, Japan. Electronic address: yamada-mas@ncchd.go.jp.
FAU - Sakamoto, Kenichi
AU  - Sakamoto K
AD  - Children's Cancer Center, National Center for Health and Development, Tokyo, 
      Japan.
FAU - Tomizawa, Daisuke
AU  - Tomizawa D
AD  - Children's Cancer Center, National Center for Health and Development, Tokyo, 
      Japan.
FAU - Ishikawa, Yuriko
AU  - Ishikawa Y
AD  - Advanced Medicine for Viral Infections, National Center for Child Health and 
      Development, Tokyo, Japan.
FAU - Matsui, Toshihiro
AU  - Matsui T
AD  - Children's Cancer Center, National Center for Health and Development, Tokyo, 
      Japan.
FAU - Gocho, Yoshihiro
AU  - Gocho Y
AD  - Children's Cancer Center, National Center for Health and Development, Tokyo, 
      Japan.
FAU - Sakaguchi, Hirotoshi
AU  - Sakaguchi H
AD  - Children's Cancer Center, National Center for Health and Development, Tokyo, 
      Japan.
FAU - Kato, Motohiro
AU  - Kato M
AD  - Children's Cancer Center, National Center for Health and Development, Tokyo, 
      Japan.
FAU - Osumi, Tomoo
AU  - Osumi T
AD  - Children's Cancer Center, National Center for Health and Development, Tokyo, 
      Japan.
FAU - Imadome, Ken-Ichi
AU  - Imadome KI
AD  - Advanced Medicine for Viral Infections, National Center for Child Health and 
      Development, Tokyo, Japan.
LA  - eng
PT  - Journal Article
PT  - Observational Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20210721
PL  - United States
TA  - Transplant Cell Ther
JT  - Transplantation and cellular therapy
JID - 101774629
SB  - IM
MH  - Child
MH  - Child, Preschool
MH  - Cytomegalovirus
MH  - Female
MH  - *Hematopoietic Stem Cell Transplantation/adverse effects
MH  - Humans
MH  - Prospective Studies
MH  - Transplantation, Homologous
MH  - *Virus Diseases/epidemiology
OTO - NOTNLM
OT  - Allogeneic hematopoietic stem cell transplantation
OT  - Pediatrics
OT  - Viral infections
EDAT- 2021/07/24 06:00
MHDA- 2021/10/21 06:00
CRDT- 2021/07/23 20:17
PHST- 2021/04/13 00:00 [received]
PHST- 2021/07/12 00:00 [revised]
PHST- 2021/07/13 00:00 [accepted]
PHST- 2021/07/24 06:00 [pubmed]
PHST- 2021/10/21 06:00 [medline]
PHST- 2021/07/23 20:17 [entrez]
AID - S2666-6367(21)01079-4 [pii]
AID - 10.1016/j.jtct.2021.07.014 [doi]
PST - ppublish
SO  - Transplant Cell Ther. 2021 Oct;27(10):872.e1-872.e8. doi: 
      10.1016/j.jtct.2021.07.014. Epub 2021 Jul 21.