PMID- 3429947
OWN - NLM
STAT- MEDLINE
DCOM- 19880314
LR  - 20221007
IS  - 0393-6155 (Print)
IS  - 0393-6155 (Linking)
VI  - 1
IP  - 3
DP  - 1986 Sep-Dec
TI  - Neuron-specific enolase in the diagnosis and therapy monitoring of lung cancer: a 
      comparison with CEA, TPA, ferritin and calcitonin.
PG  - 129-36
AB  - The significance of neuron-specific enolase (NSE) in the diagnosis and treatment 
      monitoring of lung cancer was investigated in comparison with such established 
      tumour markers as carcinoembryonic antigen (CEA), tissue polypeptide antigen 
      (TPA), ferritin and calcitonin. We determined the serum concentrations of these 
      tumour markers in 25 patients with small cell lung cancer (SCLC), 30 patients 
      with non small cell lung cancer (NSCLC), and 38 patients with benign pulmonary 
      diseases (BPD). In 14 patients with lung cancer, it was possible to follow up the 
      behaviour of the tumour markers under treatment for up to 16 months. Calcitonin 
      proved to have a surprisingly low sensitivity for SCLC. The utility of TPA and of 
      ferritin was restricted, although the sensitivity was comparably high, by the 
      high rate of false positive results. For NSCLC, CEA proved to be the best tumour 
      marker. At present, NSE appears to be the tumour marker with the greatest 
      specificity and sensitivity for SCLC. Its determination in the diagnosis, 
      treatment and follow-up of SCLC makes good sense.
FAU - Fischbach, W
AU  - Fischbach W
AD  - Medizinische Poliklinik, Universitat Wurzburg.
FAU - Jany, B
AU  - Jany B
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Int J Biol Markers
JT  - The International journal of biological markers
JID - 8712411
RN  - 0 (Antigens, Neoplasm)
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Carcinoembryonic Antigen)
RN  - 0 (Peptides)
RN  - 0 (Tissue Polypeptide Antigen)
RN  - 9007-12-9 (Calcitonin)
RN  - 9007-73-2 (Ferritins)
RN  - EC 4.2.1.11 (Phosphopyruvate Hydratase)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Antigens, Neoplasm/analysis
MH  - Biomarkers, Tumor/*blood
MH  - Calcitonin/blood
MH  - Carcinoembryonic Antigen/analysis
MH  - Female
MH  - Ferritins/blood
MH  - Humans
MH  - Lung/pathology
MH  - Lung Neoplasms/*diagnosis/therapy
MH  - Male
MH  - Middle Aged
MH  - Peptides/analysis
MH  - Phosphopyruvate Hydratase/*analysis
MH  - Tissue Polypeptide Antigen
EDAT- 1986/09/01 00:00
MHDA- 1986/09/01 00:01
CRDT- 1986/09/01 00:00
PHST- 1986/09/01 00:00 [pubmed]
PHST- 1986/09/01 00:01 [medline]
PHST- 1986/09/01 00:00 [entrez]
AID - 10.1177/172460088600100303 [doi]
PST - ppublish
SO  - Int J Biol Markers. 1986 Sep-Dec;1(3):129-36. doi: 10.1177/172460088600100303.