PMID- 34299734
OWN - NLM
STAT- MEDLINE
DCOM- 20210812
LR  - 20240506
IS  - 1660-4601 (Electronic)
IS  - 1661-7827 (Print)
IS  - 1660-4601 (Linking)
VI  - 18
IP  - 14
DP  - 2021 Jul 7
TI  - Assessment of Metal Concentrations and Associations with Pulmonary Function among 
      Children with Asthma in Chicago, Illinois.
LID - 10.3390/ijerph18147279 [doi]
LID - 7279
AB  - Individuals living in areas with the potential for elevated metal exposure from 
      industrial sources may have reduced pulmonary function. We evaluated 
      cross-sectional associations of toenail concentrations of 17 metals within a 
      community area of residence and asthma control in 75 children, and pulmonary 
      function measures [forced expiratory volume in one second (FEV1; liters), forced 
      vital capacity (FVC; liters), FEV1 to FVC ratio (FEV1:FVC), and mid-exhalation 
      forced expiratory flow rate (FEF 25-75%; liters/second)], in a subsample of 39 
      children with diagnosed asthma in Chicago, Illinois. Linear regression models 
      were used to estimate adjusted regression coefficients and standard errors (SE) 
      for the associations between >/= median versus <median metal exposures and natural 
      log-transformed (ln) pulmonary function test parameters. Toenail levels of 
      cadmium, cobalt, iron, manganese, and vanadium were higher among children 
      residing near an industrial corridor than those in a comparison community. Copper 
      concentrations were inversely associated with lnFEV1 (beta = -0.10, SE = 0.04, p = 
      0.01), lnFEV1:FVC (beta = -0.07, SE = 0.03, p = 0.02) and lnFEF 25-75% (beta = -0.25, 
      SE = 0.09, p = 0.01); manganese concentrations were inversely associated with 
      lnFEV1 (beta = -0.11, SE = 0.04, p = 0.01), lnFEV1:FVC (beta = -0.07, SE = 0.03, p = 
      0.02), and lnFEF 25-75% (beta = -0.28, SE = 0.10, p = 0.004), and vanadium 
      concentrations were inversely associated with lnFEV1 (beta = -0.08, SE = 0.04, p = 
      0.05) and lnFVC (beta = -0.07, SE = 0.03, p = 0.03). Nickel and copper were 
      associated with uncontrolled asthma (OR = 6.8; 95% CI 2.0, 22.8 and OR = 4.6; 95% 
      CI 1.0, 21.0, respectively). These data suggest that selected metal exposures may 
      be associated with impaired pulmonary function parameters and reduced asthma 
      control among children with preexisting asthma.
FAU - Madrigal, Jessica M
AU  - Madrigal JM
AUID- ORCID: 0000-0001-5303-5109
AD  - Division of Epidemiology and Biostatistics, School of Public Health, University 
      of Illinois Chicago, Chicago, IL 60612, USA.
FAU - Persky, Victoria
AU  - Persky V
AD  - Division of Epidemiology and Biostatistics, School of Public Health, University 
      of Illinois Chicago, Chicago, IL 60612, USA.
FAU - Jackson, Brian P
AU  - Jackson BP
AD  - Department of Earth Sciences, Dartmouth College, Hanover, NH 03755, USA.
FAU - Bain, Amy
AU  - Bain A
AD  - Mobile Care Chicago, Chicago, IL 60609, USA.
FAU - Siemer, Matt
AU  - Siemer M
AD  - Mobile Care Chicago, Chicago, IL 60609, USA.
FAU - Pappalardo, Andrea A
AU  - Pappalardo AA
AD  - Department of Pediatrics, College of Medicine, University of Illinois Chicago, 
      Chicago, IL 60612, USA.
AD  - Department of Medicine, College of Medicine, University of Illinois Chicago, 
      Chicago, IL 60612, USA.
FAU - Argos, Maria
AU  - Argos M
AD  - Division of Epidemiology and Biostatistics, School of Public Health, University 
      of Illinois Chicago, Chicago, IL 60612, USA.
LA  - eng
GR  - T42 OH008672/OH/NIOSH CDC HHS/United States
GR  - P42 ES007373/ES/NIEHS NIH HHS/United States
GR  - P30 CA023108/CA/NCI NIH HHS/United States
GR  - R01 ES02442304/ES/NIEHS NIH HHS/United States
GR  - P30 ES027792/ES/NIEHS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
DEP - 20210707
PL  - Switzerland
TA  - Int J Environ Res Public Health
JT  - International journal of environmental research and public health
JID - 101238455
SB  - IM
MH  - *Asthma/epidemiology
MH  - Chicago/epidemiology
MH  - Child
MH  - Cross-Sectional Studies
MH  - Forced Expiratory Volume
MH  - Humans
MH  - *Lung
MH  - Vital Capacity
PMC - PMC8307469
OTO - NOTNLM
OT  - asthma
OT  - children
OT  - metals
OT  - pulmonary function
OT  - respiratory function
COIS- The authors declare that they have no conflict of interest.
EDAT- 2021/07/25 06:00
MHDA- 2021/08/13 06:00
PMCR- 2021/07/07
CRDT- 2021/07/24 01:05
PHST- 2021/03/17 00:00 [received]
PHST- 2021/06/29 00:00 [revised]
PHST- 2021/07/01 00:00 [accepted]
PHST- 2021/07/24 01:05 [entrez]
PHST- 2021/07/25 06:00 [pubmed]
PHST- 2021/08/13 06:00 [medline]
PHST- 2021/07/07 00:00 [pmc-release]
AID - ijerph18147279 [pii]
AID - ijerph-18-07279 [pii]
AID - 10.3390/ijerph18147279 [doi]
PST - epublish
SO  - Int J Environ Res Public Health. 2021 Jul 7;18(14):7279. doi: 
      10.3390/ijerph18147279.