PMID- 34300172
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210729
IS  - 2077-0383 (Print)
IS  - 2077-0383 (Electronic)
IS  - 2077-0383 (Linking)
VI  - 10
IP  - 14
DP  - 2021 Jul 6
TI  - HLA Allele Prevalence in Disease-Modifying Antirheumatic Drugs-Responsive 
      Enthesitis and/or Arthritis Not Fulfilling ASAS Criteria: Comparison with 
      Psoriatic and Undifferentiated Spondyloarthritis.
LID - 10.3390/jcm10143006 [doi]
LID - 3006
AB  - Spondyloarthritis (SpA) is a group of inflammatory rheumatic diseases 
      characterized by common clinical features, such as inflammatory enthesitis, 
      arthritis and/or back pain. SpA is strongly associated with human leukocyte 
      antigen (HLA) class I allotype B27. Ankylosing spondylitis has historically been 
      the SpA subgroup with one of the strongest, best-proven associations with 
      HLA-B27. The remaining SpA subgroups, namely psoriatic arthritis (PsA), 
      inflammatory bowel diseases-associated arthritis/spondylitis, reactive arthritis, 
      and undifferentiated SpA (uSpA), have also been associated with HLA allotypes 
      other than HLA-B27. In this retrospective study, we analyzed the association 
      between the HLA class I and II haplotypes and the susceptibility to enthesitis 
      and/or arthritis (E/A). Special attention was paid to E/A responding to 
      disease-modifying antirheumatic drugs (DMARDs) not fulfilling ASAS classification 
      criteria (ASAS(-)), as compared to ASAS(+) forms including PsA and uSpA. The 
      whole E/A group showed significant independent associations with HLA-A28(68), 
      B27, Cw3, Cw12, and DQ1; taken singly, PsA was associated with HLA-B27 and DQ1, 
      uSpA with HLA-B16(38,39) and B27, and E/A ASAS(-) with HLA-A28(68), Cw8, and 
      Cw12. This study identified novel risk HLA allotypes for different SpA subgroups 
      in an Italian population. HLA typing could aid the diagnosis and treatment of E/A 
      subgroups, including DMARDS-responsive forms not fulfilling ASAS classification 
      criteria.
FAU - Favoino, Elvira
AU  - Favoino E
AD  - Department of Biomedical Science and Human Oncology (DIMO), Rheumatic and 
      Systemic Autoimmune Diseases Unit, University of Bari Medical School, Piazza G. 
      Cesare 11, I-70124 Bari, Italy.
FAU - Urso, Livio
AU  - Urso L
AD  - Department of Biomedical Science and Human Oncology (DIMO), Rheumatic and 
      Systemic Autoimmune Diseases Unit, University of Bari Medical School, Piazza G. 
      Cesare 11, I-70124 Bari, Italy.
FAU - Serafino, Alessandra
AU  - Serafino A
AD  - Department of Biomedical Science and Human Oncology (DIMO), Rheumatic and 
      Systemic Autoimmune Diseases Unit, University of Bari Medical School, Piazza G. 
      Cesare 11, I-70124 Bari, Italy.
FAU - Misceo, Francesca
AU  - Misceo F
AD  - Department of Biomedical Science and Human Oncology (DIMO), Rheumatic and 
      Systemic Autoimmune Diseases Unit, University of Bari Medical School, Piazza G. 
      Cesare 11, I-70124 Bari, Italy.
FAU - Catacchio, Giacomo
AU  - Catacchio G
AD  - Department of Biomedical Science and Human Oncology (DIMO), Rheumatic and 
      Systemic Autoimmune Diseases Unit, University of Bari Medical School, Piazza G. 
      Cesare 11, I-70124 Bari, Italy.
FAU - Prete, Marcella
AU  - Prete M
AD  - Department of Biomedical Science and Human Oncology (DIMO), Rheumatic and 
      Systemic Autoimmune Diseases Unit, University of Bari Medical School, Piazza G. 
      Cesare 11, I-70124 Bari, Italy.
FAU - Perosa, Federico
AU  - Perosa F
AUID- ORCID: 0000-0002-4072-4244
AD  - Department of Biomedical Science and Human Oncology (DIMO), Rheumatic and 
      Systemic Autoimmune Diseases Unit, University of Bari Medical School, Piazza G. 
      Cesare 11, I-70124 Bari, Italy.
LA  - eng
GR  - C.O.2018/University of Bari Medical School/
PT  - Journal Article
DEP - 20210706
PL  - Switzerland
TA  - J Clin Med
JT  - Journal of clinical medicine
JID - 101606588
PMC - PMC8305973
OTO - NOTNLM
OT  - ASAS classification criteria
OT  - clinical management
OT  - human leukocyte antigen
OT  - spondyloarthritis
OT  - undifferentiated enthesitis and/or arthritis
COIS- The authors declare no conflict of interest.
EDAT- 2021/07/25 06:00
MHDA- 2021/07/25 06:01
PMCR- 2021/07/06
CRDT- 2021/07/24 01:06
PHST- 2021/05/28 00:00 [received]
PHST- 2021/06/30 00:00 [revised]
PHST- 2021/07/03 00:00 [accepted]
PHST- 2021/07/24 01:06 [entrez]
PHST- 2021/07/25 06:00 [pubmed]
PHST- 2021/07/25 06:01 [medline]
PHST- 2021/07/06 00:00 [pmc-release]
AID - jcm10143006 [pii]
AID - jcm-10-03006 [pii]
AID - 10.3390/jcm10143006 [doi]
PST - epublish
SO  - J Clin Med. 2021 Jul 6;10(14):3006. doi: 10.3390/jcm10143006.