PMID- 34302045
OWN - NLM
STAT- MEDLINE
DCOM- 20211102
LR  - 20211102
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 11
IP  - 1
DP  - 2021 Jul 23
TI  - Detectability of pulmonary ossifications in fibrotic lung on 
      ultra-high-resolution CT using 2048 matrix size and 0.25-mm slice thickness.
PG  - 15119
LID - 10.1038/s41598-021-94596-5 [doi]
LID - 15119
AB  - To investigate the prevalence of nodular pulmonary ossifications (POs) in 
      patients with honeycombing on ultra-high-resolution CT (UHRCT) and to compare the 
      detectability of nodular POs between images reconstructed using the 
      ultra-high-resolution setting (UHR-setting) and those using the conventional 
      setting (C-setting) on UHRCT. Twenty patients with honeycombing in the lung were 
      evaluated retrospectively. All patients underwent non-contrast-enhanced UHRCT. 
      Images were reconstructed with UHR-setting (matrix, 2048 x 2048; slice thickness, 
      0.25 mm) and with C-setting (matrix size, 512 x 512; slice thickness, 0.5 mm). 
      Two chest radiologists independently recorded the number of nodular POs (< 4 mm 
      diameter) in each lung lobes. Each lobe was classified as one of the following 
      five categories according to the number of POs: C0, none; C1, 1-4 POs; C2, 5-9 
      POs; C3, 10-49 POs; and C4, >/= 50 POs. The maximum CT values of the POs were 
      measured and compared between the two settings. PO categories were significantly 
      higher with UHR-setting than with C-setting (p < 0.001). Maximum CT values were 
      significantly higher with UHR-setting than with C-setting (p < 0.001). Nodular 
      POs were seen in 80% or more of patients with honeycombing and more easily 
      detected in images reconstructed with UHR-setting than in those with C-setting.
CI  - (c) 2021. The Author(s).
FAU - Hata, Akinori
AU  - Hata A
AD  - Department of Diagnostic and Interventional Radiology, Osaka University Graduate 
      School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan. 
      a-hata@radiol.med.osaka-u.ac.jp.
FAU - Yanagawa, Masahiro
AU  - Yanagawa M
AD  - Department of Diagnostic and Interventional Radiology, Osaka University Graduate 
      School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.
FAU - Tsubamoto, Mitsuko
AU  - Tsubamoto M
AD  - Department of Radiology, Nishinomiya Municipal Hospital, 8-24 Hayashida-cho, 
      Nishinomiya, Hyogo, 663-8014, Japan.
FAU - Doi, Shuhei
AU  - Doi S
AD  - Department of Diagnostic and Interventional Radiology, Osaka University Graduate 
      School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.
FAU - Yoshida, Yuriko
AU  - Yoshida Y
AD  - Department of Diagnostic and Interventional Radiology, Osaka University Graduate 
      School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.
FAU - Miyata, Tomo
AU  - Miyata T
AD  - Department of Future Diagnostic Radiology, Osaka University Graduate School of 
      Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.
FAU - Kikuchi, Noriko
AU  - Kikuchi N
AD  - Department of Diagnostic and Interventional Radiology, Osaka University Graduate 
      School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.
FAU - Kashiwagi, Nobuo
AU  - Kashiwagi N
AD  - Department of Future Diagnostic Radiology, Osaka University Graduate School of 
      Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.
FAU - Tomiyama, Noriyuki
AU  - Tomiyama N
AD  - Department of Diagnostic and Interventional Radiology, Osaka University Graduate 
      School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.
LA  - eng
PT  - Journal Article
DEP - 20210723
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
SB  - IM
MH  - Aged
MH  - Female
MH  - Humans
MH  - Lung/*pathology
MH  - Male
MH  - Osteogenesis/physiology
MH  - Pulmonary Fibrosis/*pathology
MH  - Retrospective Studies
MH  - Tomography, X-Ray Computed/methods
PMC - PMC8302596
COIS- The authors (A.H., M.T., T.M., and N.K.) report non-financial support from Canon 
      Medical Systems, outside the submitted work. All authors (A.H., M.Y., M.T., S.D., 
      Y.Y., T.M., N.K., N.K., and N.T.) state that they have not received any funding 
      for this work.
EDAT- 2021/07/25 06:00
MHDA- 2021/11/03 06:00
PMCR- 2021/07/23
CRDT- 2021/07/24 06:14
PHST- 2021/04/23 00:00 [received]
PHST- 2021/07/13 00:00 [accepted]
PHST- 2021/07/24 06:14 [entrez]
PHST- 2021/07/25 06:00 [pubmed]
PHST- 2021/11/03 06:00 [medline]
PHST- 2021/07/23 00:00 [pmc-release]
AID - 10.1038/s41598-021-94596-5 [pii]
AID - 94596 [pii]
AID - 10.1038/s41598-021-94596-5 [doi]
PST - epublish
SO  - Sci Rep. 2021 Jul 23;11(1):15119. doi: 10.1038/s41598-021-94596-5.