PMID- 34302064
OWN - NLM
STAT- MEDLINE
DCOM- 20220323
LR  - 20230206
IS  - 2042-0226 (Electronic)
IS  - 1672-7681 (Print)
IS  - 1672-7681 (Linking)
VI  - 18
IP  - 11
DP  - 2021 Nov
TI  - Dendritic cell migration in inflammation and immunity.
PG  - 2461-2471
LID - 10.1038/s41423-021-00726-4 [doi]
AB  - Dendritic cells (DCs) are the key link between innate immunity and adaptive 
      immunity and play crucial roles in both the promotion of immune defense and the 
      maintenance of immune tolerance. The trafficking of distinct DC subsets across 
      lymphoid and nonlymphoid tissues is essential for DC-dependent activation and 
      regulation of inflammation and immunity. DC chemotaxis and migration are 
      triggered by interactions between chemokines and their receptors and regulated by 
      multiple intracellular mechanisms, such as protein modification, epigenetic 
      reprogramming, metabolic remodeling, and cytoskeletal rearrangement, in a 
      tissue-specific manner. Dysregulation of DC migration may lead to abnormal 
      positioning or activation of DCs, resulting in an imbalance of immune responses 
      and even immune pathologies, including autoimmune responses, infectious diseases, 
      allergic diseases and tumors. New strategies targeting the migration of distinct 
      DC subsets are being explored for the treatment of inflammatory and infectious 
      diseases and the development of novel DC-based vaccines. In this review, we will 
      discuss the migratory routes and immunological consequences of distinct DC 
      subsets, the molecular basis and regulatory mechanisms of migratory signaling in 
      DCs, and the association of DC migration with the pathogenesis of autoimmune and 
      infectious diseases.
CI  - (c) 2021. The Author(s), under exclusive licence to CSI and USTC.
FAU - Liu, Juan
AU  - Liu J
AD  - National Key Laboratory of Medical Immunology & Institute of Immunology, Second 
      Military Medical University, Shanghai, China. juanliu@immunol.org.
FAU - Zhang, Xiaomin
AU  - Zhang X
AD  - National Key Laboratory of Medical Immunology & Institute of Immunology, Second 
      Military Medical University, Shanghai, China.
FAU - Cheng, Yujie
AU  - Cheng Y
AD  - National Key Laboratory of Medical Immunology & Institute of Immunology, Second 
      Military Medical University, Shanghai, China.
FAU - Cao, Xuetao
AU  - Cao X
AD  - National Key Laboratory of Medical Immunology & Institute of Immunology, Second 
      Military Medical University, Shanghai, China. caoxt@immunol.org.
AD  - Department of Immunology, Center for Immunotherapy, Institute of Basic Medical 
      Sciences, Chinese Academy of Medical Sciences, Beijing, China. caoxt@immunol.org.
LA  - eng
GR  - 32070903/National Natural Science Foundation of China (National Science 
      Foundation of China)/
GR  - 31870909/National Natural Science Foundation of China (National Science 
      Foundation of China)/
GR  - 81788101/National Natural Science Foundation of China (National Science 
      Foundation of China)/
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20210723
PL  - China
TA  - Cell Mol Immunol
JT  - Cellular & molecular immunology
JID - 101242872
RN  - 0 (CCR7 protein, human)
RN  - 0 (Receptors, CCR7)
SB  - IM
MH  - Adaptive Immunity
MH  - Animals
MH  - Autoimmune Diseases/*immunology
MH  - Autoimmunity
MH  - Cell Movement/*immunology
MH  - Communicable Diseases/*immunology
MH  - Dendritic Cells/*immunology
MH  - Humans
MH  - Inflammation/*immunology
MH  - Receptors, CCR7/metabolism
PMC - PMC8298985
OTO - NOTNLM
OT  - autoimmune diseases
OT  - cell migration
OT  - chemokine receptor CCR7
OT  - dendritic cells
OT  - inflammation
COIS- The authors declare no competing interests.
EDAT- 2021/07/25 06:00
MHDA- 2022/03/24 06:00
PMCR- 2022/11/01
CRDT- 2021/07/24 06:16
PHST- 2021/05/03 00:00 [received]
PHST- 2021/06/09 00:00 [accepted]
PHST- 2021/07/25 06:00 [pubmed]
PHST- 2022/03/24 06:00 [medline]
PHST- 2021/07/24 06:16 [entrez]
PHST- 2022/11/01 00:00 [pmc-release]
AID - 10.1038/s41423-021-00726-4 [pii]
AID - 726 [pii]
AID - 10.1038/s41423-021-00726-4 [doi]
PST - ppublish
SO  - Cell Mol Immunol. 2021 Nov;18(11):2461-2471. doi: 10.1038/s41423-021-00726-4. 
      Epub 2021 Jul 23.