PMID- 34304372
OWN - NLM
STAT- MEDLINE
DCOM- 20220331
LR  - 20220401
IS  - 1573-6903 (Electronic)
IS  - 0364-3190 (Print)
IS  - 0364-3190 (Linking)
VI  - 47
IP  - 1
DP  - 2022 Jan
TI  - The Lepidopteran KAAT1 and CAATCH1: Orthologs to Understand Structure-Function 
      Relationships in Mammalian SLC6 Transporters.
PG  - 111-126
LID - 10.1007/s11064-021-03410-1 [doi]
AB  - To the SLC6 family belong 20 human transporters that utilize the sodium 
      electrochemical gradient to move biogenic amines, osmolytes, amino acids and 
      related compounds into cells. They are classified into two functional groups, the 
      Neurotransmitter transporters (NTT) and Nutrient amino acid transporters (NAT). 
      Here we summarize how since their first cloning in 1998, the insect 
      (Lepidopteran) Orthologs of the SLC6 family transporters have represented very 
      important tools for investigating functional-structural relationships, mechanism 
      of transport, ion and pH dependence and substate interaction of the mammalian 
      (and human) counterparts.
CI  - (c) 2021. The Author(s).
FAU - Castagna, Michela
AU  - Castagna M
AD  - Department of Pharmacological and Biomolecular Sciences, Universita degli Studi 
      di Milano, Via Trentacoste 2, 20134, Milan, Italy.
FAU - Cinquetti, Raffaella
AU  - Cinquetti R
AD  - Laboratory of Cellular and Molecular Physiology, Department of Biotechnology and 
      Life Sciences, University of Insubria, via Dunant 3, 21100, Varese, Italy.
FAU - Verri, Tiziano
AU  - Verri T
AD  - Laboratory of Applied Physiology, Department of Biological and Environmental 
      Sciences and Technologies, University of Salento, Via Provinciale 
      Lecce-Monteroni, 73100, Lecce, Italy.
FAU - Vacca, Francesca
AU  - Vacca F
AD  - Laboratory of Cellular and Molecular Physiology, Department of Biotechnology and 
      Life Sciences, University of Insubria, via Dunant 3, 21100, Varese, Italy.
FAU - Giovanola, Matteo
AU  - Giovanola M
AD  - Department of Pharmacological and Biomolecular Sciences, Universita degli Studi 
      di Milano, Via Trentacoste 2, 20134, Milan, Italy.
FAU - Barca, Amilcare
AU  - Barca A
AD  - Laboratory of Applied Physiology, Department of Biological and Environmental 
      Sciences and Technologies, University of Salento, Via Provinciale 
      Lecce-Monteroni, 73100, Lecce, Italy.
FAU - Romanazzi, Tiziana
AU  - Romanazzi T
AD  - Laboratory of Cellular and Molecular Physiology, Department of Biotechnology and 
      Life Sciences, University of Insubria, via Dunant 3, 21100, Varese, Italy.
FAU - Roseti, Cristina
AU  - Roseti C
AD  - Laboratory of Cellular and Molecular Physiology, Department of Biotechnology and 
      Life Sciences, University of Insubria, via Dunant 3, 21100, Varese, Italy.
AD  - Research Centre for Neuroscience, University of Insubria, Varese, Italy.
FAU - Galli, Alessandra
AU  - Galli A
AD  - Department of Pharmacological and Biomolecular Sciences, Universita degli Studi 
      di Milano, Via Trentacoste 2, 20134, Milan, Italy.
FAU - Bossi, Elena
AU  - Bossi E
AUID- ORCID: 0000-0002-9549-2153
AD  - Laboratory of Cellular and Molecular Physiology, Department of Biotechnology and 
      Life Sciences, University of Insubria, via Dunant 3, 21100, Varese, Italy. 
      elena.bossi@uninsubria.it.
AD  - Research Centre for Neuroscience, University of Insubria, Varese, Italy. 
      elena.bossi@uninsubria.it.
LA  - eng
GR  - 813898/H2020 Marie Sklodowska-Curie Actions/
PT  - Journal Article
DEP - 20210724
PL  - United States
TA  - Neurochem Res
JT  - Neurochemical research
JID - 7613461
RN  - 0 (Amino Acid Transport Systems)
RN  - 0 (Carrier Proteins)
RN  - 0 (Insect Proteins)
RN  - 0 (Membrane Proteins)
SB  - IM
MH  - Amino Acid Transport Systems/metabolism
MH  - Animals
MH  - *Carrier Proteins/metabolism
MH  - Humans
MH  - Insect Proteins/chemistry/genetics/metabolism
MH  - Mammals/metabolism
MH  - *Membrane Proteins/metabolism
MH  - Structure-Activity Relationship
PMC - PMC8310414
OTO - NOTNLM
OT  - ACE2
OT  - Electrophysiology
OT  - Membrane transporters
OT  - Neurotransmitter transporters
OT  - Nutrient transporters
OT  - SLC6
OT  - Xenopus laevis oocytes
COIS- The authors declare no conflict of interest, financial or otherwise.
EDAT- 2021/07/26 06:00
MHDA- 2022/04/01 06:00
PMCR- 2021/07/24
CRDT- 2021/07/25 20:55
PHST- 2021/04/18 00:00 [received]
PHST- 2021/07/20 00:00 [accepted]
PHST- 2021/04/18 00:00 [revised]
PHST- 2021/07/26 06:00 [pubmed]
PHST- 2022/04/01 06:00 [medline]
PHST- 2021/07/25 20:55 [entrez]
PHST- 2021/07/24 00:00 [pmc-release]
AID - 10.1007/s11064-021-03410-1 [pii]
AID - 3410 [pii]
AID - 10.1007/s11064-021-03410-1 [doi]
PST - ppublish
SO  - Neurochem Res. 2022 Jan;47(1):111-126. doi: 10.1007/s11064-021-03410-1. Epub 2021 
      Jul 24.