PMID- 34305416
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231107
IS  - 1179-2736 (Print)
IS  - 1179-2736 (Electronic)
IS  - 1179-2736 (Linking)
VI  - 12
DP  - 2021
TI  - Coagulopathy in SARS-CoV-2 Infected Patients: Implication for the Management of 
      COVID-19.
PG  - 635-643
LID - 10.2147/JBM.S304783 [doi]
AB  - COVID-19 disease has led to an extraordinary inclusive health crisis globally. 
      Elevation of D-dimer is the major remarkable abnormal coagulation test in 
      seriously ill COVID-19 patients. In nearly 50% of COVID-19 patients, the value of 
      D-dimer was significantly enhancing. Recent literature indicated that COVID-19 
      patients were at higher risk of developing disseminated intravascular 
      coagulation. Pro-inflammatory cytokines and chemokines are some of the factors 
      leading to these conditions. The majority of COVID-19 patients showed a higher 
      profile of pro-inflammatory cytokines and chemokines in severe clinical 
      conditions. Tumor necrosis factor-alpha (TNF-alpha) and interleukins (ILs) elevated in 
      COVID-19 infected patients. TNF-alpha, IL-6, and IL-1 are major cytokines vital for 
      the inhibition of intrinsic anticoagulant pathways. COVID-19 becomes a higher 
      complication with a significant effect on blood cell production and hemostasis 
      cascades. Deep vein thrombosis and arterial thrombosis are common complications. 
      Changes in hematological parameters are also frequently observed in COVID-19 
      patients. Especially, thrombocytopenia is an indicator for poor prognosis of the 
      disease and is highly expected and aggravates the likelihood of death of 
      SARS-CoV-2 infected individuals. Thrombopoiesis reduction in COVID-19 patients 
      might be due to viral abuse of the bone marrow/the viral load may affect 
      thrombopoietin production and function. In other ways, 
      immune-inflammation-mediated destruction and increased consumption of platelets 
      are also the possible proposed mechanisms for thrombocytopenia. Therefore, the 
      counting of platelet cells is an easily accessible biomarker for disease 
      monitoring. All SARS-CoV-2 infected patients should be admitted and identifying 
      potential higher-risk patients. It is also obligatory to provide appropriate 
      treatments with intensive care and strict follow-up. In addition, considerations 
      of chronic diseases are essential for better prognosis and recovery. The current 
      review discusses coagulopathy among SARS-CoV-2 infected individuals and its 
      complication for the management of the disease.
CI  - (c) 2021 Getu et al.
FAU - Getu, Sisay
AU  - Getu S
AUID- ORCID: 0000-0002-0321-8342
AD  - Hematology and Immuno-hematology, Medical Laboratory Science, College of Health 
      Sciences, Debre Tabor University, Debre Tabor, Ethiopia.
FAU - Tiruneh, Tegenaw
AU  - Tiruneh T
AUID- ORCID: 0000-0002-2859-4280
AD  - Hematology and Immuno-hematology, Medical Laboratory Science, College of Health 
      Sciences, Debre Tabor University, Debre Tabor, Ethiopia.
FAU - Andualem, Henok
AU  - Andualem H
AUID- ORCID: 0000-0001-6883-9548
AD  - Immunology and Molecular Biology, Medical Laboratory Science, College of Health 
      Sciences, Debre Tabor University, Debre Tabor, Ethiopia.
FAU - Hailemichael, Wasihun
AU  - Hailemichael W
AUID- ORCID: 0000-0003-2721-7632
AD  - Immunology and Molecular Biology, Medical Laboratory Science, College of Health 
      Sciences, Debre Tabor University, Debre Tabor, Ethiopia.
FAU - Kiros, Teklehayimanot
AU  - Kiros T
AUID- ORCID: 0000-0002-3107-4833
AD  - Microbiology, Medical Laboratory Science, College of Health Sciences, Debre Tabor 
      University, Debre Tabor, Ethiopia.
FAU - Mesfin Belay, Demeke
AU  - Mesfin Belay D
AUID- ORCID: 0000-0003-4786-2866
AD  - Pediatrics and Child Health Nursing, College of Health Sciences, Debre Tabor 
      University, Debre Tabor, Ethiopia.
FAU - Kiros, Mulugeta
AU  - Kiros M
AUID- ORCID: 0000-0002-7909-7719
AD  - Microbiology, Medical Laboratory Science, College of Health Sciences, Debre Tabor 
      University, Debre Tabor, Ethiopia.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20210717
PL  - New Zealand
TA  - J Blood Med
JT  - Journal of blood medicine
JID - 101550884
PMC - PMC8296964
OTO - NOTNLM
OT  - COVID-19
OT  - DIC
OT  - SARS-CoV-2
OT  - coagulopathy
COIS- The authors declared no conflicts of interest for this work.
EDAT- 2021/07/27 06:00
MHDA- 2021/07/27 06:01
PMCR- 2021/07/17
CRDT- 2021/07/26 06:19
PHST- 2021/02/01 00:00 [received]
PHST- 2021/06/16 00:00 [accepted]
PHST- 2021/07/26 06:19 [entrez]
PHST- 2021/07/27 06:00 [pubmed]
PHST- 2021/07/27 06:01 [medline]
PHST- 2021/07/17 00:00 [pmc-release]
AID - 304783 [pii]
AID - 10.2147/JBM.S304783 [doi]
PST - epublish
SO  - J Blood Med. 2021 Jul 17;12:635-643. doi: 10.2147/JBM.S304783. eCollection 2021.