PMID- 34307500 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20210727 IS - 2297-055X (Print) IS - 2297-055X (Electronic) IS - 2297-055X (Linking) VI - 8 DP - 2021 TI - Overview of Veno-Arterial Extracorporeal Membrane Oxygenation (VA-ECMO) Support for the Management of Cardiogenic Shock. PG - 686558 LID - 10.3389/fcvm.2021.686558 [doi] LID - 686558 AB - Cardiogenic shock accounts for ~100,000 annual hospital admissions in the United States. Despite improvements in medical management strategies, in-hospital mortality remains unacceptably high. Multiple mechanical circulatory support devices have been developed with the aim to provide hemodynamic support and to improve outcomes in this population. Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) is the most advanced temporary life support system that is unique in that it provides immediate and complete hemodynamic support as well as concomitant gas exchange. In this review, we discuss the fundamental concepts and hemodynamic aspects of VA-ECMO support in patients with cardiogenic shock of various etiologies. In addition, we review the common indications, contraindications and complications associated with VA-ECMO use. CI - Copyright (c) 2021 Tsangaris, Alexy, Kalra, Kosmopoulos, Elliott, Bartos and Yannopoulos. FAU - Tsangaris, Adamantios AU - Tsangaris A AD - Division of Cardiology, Department of Medicine, University of Minnesota, Minneapolis, MN, United States. FAU - Alexy, Tamas AU - Alexy T AD - Division of Cardiology, Department of Medicine, University of Minnesota, Minneapolis, MN, United States. FAU - Kalra, Rajat AU - Kalra R AD - Division of Cardiology, Department of Medicine, University of Minnesota, Minneapolis, MN, United States. FAU - Kosmopoulos, Marinos AU - Kosmopoulos M AD - Center for Resuscitation Medicine, University of Minnesota School of Medicine, Minneapolis, MN, United States. FAU - Elliott, Andrea AU - Elliott A AD - Division of Cardiology, Department of Medicine, University of Minnesota, Minneapolis, MN, United States. FAU - Bartos, Jason A AU - Bartos JA AD - Division of Cardiology, Department of Medicine, University of Minnesota, Minneapolis, MN, United States. AD - Center for Resuscitation Medicine, University of Minnesota School of Medicine, Minneapolis, MN, United States. FAU - Yannopoulos, Demetris AU - Yannopoulos D AD - Division of Cardiology, Department of Medicine, University of Minnesota, Minneapolis, MN, United States. AD - Center for Resuscitation Medicine, University of Minnesota School of Medicine, Minneapolis, MN, United States. LA - eng PT - Journal Article PT - Review DEP - 20210707 PL - Switzerland TA - Front Cardiovasc Med JT - Frontiers in cardiovascular medicine JID - 101653388 PMC - PMC8292640 OTO - NOTNLM OT - VA-ECMO complications OT - VA-ECMO indications OT - cardiogenic shock OT - extracorporeal membrane oxygenation OT - mechanical circulatory support COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2021/07/27 06:00 MHDA- 2021/07/27 06:01 PMCR- 2021/01/01 CRDT- 2021/07/26 06:39 PHST- 2021/03/27 00:00 [received] PHST- 2021/06/11 00:00 [accepted] PHST- 2021/07/26 06:39 [entrez] PHST- 2021/07/27 06:00 [pubmed] PHST- 2021/07/27 06:01 [medline] PHST- 2021/01/01 00:00 [pmc-release] AID - 10.3389/fcvm.2021.686558 [doi] PST - epublish SO - Front Cardiovasc Med. 2021 Jul 7;8:686558. doi: 10.3389/fcvm.2021.686558. eCollection 2021.